rs7649435

Homo sapiens
A>G
None
Check p-value
SNV (Single Nucleotide Variation)
G=0494 (14781/29884,GnomAD)
A==0484 (14100/29118,TOPMED)
A==0442 (2216/5008,1000G)
G=0393 (1516/3854,ALSPAC)
G=0390 (1446/3708,TWINSUK)
chr3:116634685 (GRCh38.p7) (3q13.31)
AD
GWASdb2
1   publication(s)
See rs on genome
28 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.116634685A>G
GRCh37.p13 chr 3NC_000003.11:g.116353532A>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.339G=0.661
1000GenomesAmericanSub694A=0.450G=0.550
1000GenomesEast AsianSub1008A=0.324G=0.676
1000GenomesEuropeSub1006A=0.590G=0.410
1000GenomesGlobalStudy-wide5008A=0.442G=0.558
1000GenomesSouth AsianSub978A=0.550G=0.450
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.607G=0.393
The Genome Aggregation DatabaseAfricanSub8696A=0.383G=0.617
The Genome Aggregation DatabaseAmericanSub836A=0.410G=0.590
The Genome Aggregation DatabaseEast AsianSub1604A=0.285G=0.715
The Genome Aggregation DatabaseEuropeSub18446A=0.583G=0.416
The Genome Aggregation DatabaseGlobalStudy-wide29884A=0.505G=0.494
The Genome Aggregation DatabaseOtherSub302A=0.680G=0.320
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.484G=0.515
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.610G=0.390
PMID Title Author Journal
22072270Genome-wide association study identifies 5q21 and 9p24.1 (KDM4C) loci associated with alcohol withdrawal symptoms.Wang KSJ Neural Transm (Vienna)

P-Value

SNP ID p-value Traits Study
rs76494352.58E-05alcohol withdrawal symptoms22072270

eQTL of rs7649435 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7649435 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr3116382620116382698E06729088
chr3116387731116387793E06734199
chr3116389966116390245E06736434
chr3116387731116387793E06834199
chr3116389966116390245E06836434
chr3116326172116326222E069-27310
chr3116326385116326454E069-27078
chr3116381954116382411E06928422
chr3116382499116382597E06928967
chr3116382620116382698E06929088
chr3116387731116387793E06934199
chr3116381954116382411E07128422
chr3116382499116382597E07128967
chr3116382620116382698E07129088
chr3116387731116387793E07134199
chr3116389966116390245E07136434
chr3116326172116326222E072-27310
chr3116326385116326454E072-27078
chr3116389966116390245E07236434
chr3116382499116382597E07328967
chr3116382620116382698E07329088
chr3116326172116326222E074-27310
chr3116326385116326454E074-27078
chr3116381954116382411E07428422
chr3116382499116382597E07428967
chr3116387731116387793E07434199
chr3116389966116390245E07436434
chr3116361847116362239E0818315