rs7657958

Homo sapiens
G>A
UGT2B10 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0066 (1974/29878,GnomAD)
A=0062 (1824/29118,TOPMED)
A=0044 (219/5008,1000G)
A=0097 (375/3854,ALSPAC)
A=0114 (421/3708,TWINSUK)
chr4:68817077 (GRCh38.p7) (4q13.2)
ND
GWASdb2
3   publication(s)
See rs on genome
0 Enhancer around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.68817077G>A
GRCh37.p13 chr 4NC_000004.11:g.69682795G>A
GRCh38.p7 chr 4 alt locus HSCHR4_1_CTG9NT_167250.2:g.393096G>A
GRCh37.p13 chr 4 alt locus HSCHR4_1_CTG9NT_167250.1:g.395046G>A

Gene: UGT2B10, UDP glucuronosyltransferase family 2 member B10(plus strand)

Molecule type Change Amino acid[Codon] SO Term
UGT2B10 transcript variant 1NM_001075.5:c.N/AIntron Variant
UGT2B10 transcript variant 2NM_001144767.2:c.N/AIntron Variant
UGT2B10 transcript variant 3NM_001290091.1:c.N/AIntron Variant
UGT2B10 transcript variant X1XM_017008585.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.965A=0.035
1000GenomesAmericanSub694G=0.930A=0.070
1000GenomesEast AsianSub1008G=0.999A=0.001
1000GenomesEuropeSub1006G=0.909A=0.091
1000GenomesGlobalStudy-wide5008G=0.956A=0.044
1000GenomesSouth AsianSub978G=0.970A=0.030
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.903A=0.097
The Genome Aggregation DatabaseAfricanSub8718G=0.956A=0.044
The Genome Aggregation DatabaseAmericanSub834G=0.950A=0.050
The Genome Aggregation DatabaseEast AsianSub1592G=0.999A=0.001
The Genome Aggregation DatabaseEuropeSub18432G=0.917A=0.082
The Genome Aggregation DatabaseGlobalStudy-wide29878G=0.933A=0.066
The Genome Aggregation DatabaseOtherSub302G=0.920A=0.080
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.937A=0.062
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.886A=0.114
PMID Title Author Journal
17909004Glucuronidation of nicotine and cotinine by UGT2B10: loss of function by the UGT2B10 Codon 67 (Asp>Tyr) polymorphism.Chen GCancer Res
18300939Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines.Chen GPharmacogenet Genomics
24944790Screening for 392 polymorphisms in 141 pharmacogenes.Kim JYBiomed Rep

P-Value

SNP ID p-value Traits Study
rs76579580.001Drug response to nicotine17909004
rs76579580.001Drug response to nicotine18300939

eQTL of rs7657958 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr4:69682795RP11-468N14.13ENSG00000272626.1G>A2.2180e-9-89906Cerebellum

meQTL of rs7657958 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.