rs7659440

Homo sapiens
G>T
None
Check p-value
SNV (Single Nucleotide Variation)
G==0498 (14855/29806,GnomAD)
G==0474 (13825/29118,TOPMED)
T=0496 (2483/5008,1000G)
T=0498 (1918/3854,ALSPAC)
G==0492 (1824/3708,TWINSUK)
chr4:35513788 (GRCh38.p7) (4p15.1)
ND
GWASdb2
1   publication(s)
See rs on genome
3 Enhancers around
18 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.35513788G>T
GRCh37.p13 chr 4NC_000004.11:g.35515410G>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.446T=0.554
1000GenomesAmericanSub694G=0.460T=0.540
1000GenomesEast AsianSub1008G=0.706T=0.294
1000GenomesEuropeSub1006G=0.528T=0.472
1000GenomesGlobalStudy-wide5008G=0.504T=0.496
1000GenomesSouth AsianSub978G=0.380T=0.620
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.502T=0.498
The Genome Aggregation DatabaseAfricanSub8692G=0.452T=0.548
The Genome Aggregation DatabaseAmericanSub830G=0.420T=0.580
The Genome Aggregation DatabaseEast AsianSub1596G=0.738T=0.262
The Genome Aggregation DatabaseEuropeSub18386G=0.501T=0.498
The Genome Aggregation DatabaseGlobalStudy-wide29806G=0.498T=0.501
The Genome Aggregation DatabaseOtherSub302G=0.570T=0.430
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.474T=0.525
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.492T=0.508
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs76594400.000229nicotine dependence17158188

eQTL of rs7659440 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7659440 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr43552673735526787E07411327
chr43553670135536912E08221291
chr43553699835537160E08221588


Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr43546683035466880E067-48530
chr43552687235526986E06811462
chr43552703435527236E06811624
chr43552753335527608E06812123
chr43546683035466880E069-48530
chr43552687235526986E06911462
chr43552703435527236E06911624
chr43546683035466880E071-48530
chr43552687235526986E07111462
chr43552703435527236E07111624
chr43552753335527608E07112123
chr43546683035466880E072-48530
chr43552687235526986E07211462
chr43552703435527236E07211624
chr43552687235526986E07311462
chr43552703435527236E07311624
chr43552687235526986E07411462
chr43552703435527236E07411624