rs7681618

Homo sapiens
A>G
None
Check p-value
SNV (Single Nucleotide Variation)
A==0384 (11490/29878,GnomAD)
A==0365 (10631/29118,TOPMED)
A==0299 (1495/5008,1000G)
A==0391 (1506/3854,ALSPAC)
A==0397 (1471/3708,TWINSUK)
chr4:67448722 (GRCh38.p7) (4q13.2)
AD
GWASdb2
1   publication(s)
See rs on genome
26 Enhancers around
1 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.67448722A>G
GRCh37.p13 chr 4NC_000004.11:g.68314440A>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.378G=0.622
1000GenomesAmericanSub694A=0.240G=0.760
1000GenomesEast AsianSub1008A=0.174G=0.826
1000GenomesEuropeSub1006A=0.375G=0.625
1000GenomesGlobalStudy-wide5008A=0.299G=0.701
1000GenomesSouth AsianSub978A=0.280G=0.720
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.391G=0.609
The Genome Aggregation DatabaseAfricanSub8712A=0.360G=0.640
The Genome Aggregation DatabaseAmericanSub834A=0.250G=0.750
The Genome Aggregation DatabaseEast AsianSub1612A=0.174G=0.826
The Genome Aggregation DatabaseEuropeSub18418A=0.421G=0.578
The Genome Aggregation DatabaseGlobalStudy-wide29878A=0.384G=0.615
The Genome Aggregation DatabaseOtherSub302A=0.320G=0.680
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.365G=0.634
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.397G=0.603
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs76816180.000277alcohol dependence20201924

eQTL of rs7681618 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7681618 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr46830252468302708E067-11732
chr46830369068303910E067-10530
chr46830397768304613E067-9827
chr46833071468330762E06716274
chr46833127268331554E06716832
chr46833127268331554E06816832
chr46830252468302708E069-11732
chr46830369068303910E069-10530
chr46830397768304613E069-9827
chr46833071468330762E06916274
chr46833127268331554E06916832
chr46830252468302708E071-11732
chr46833127268331554E07116832
chr46830369068303910E072-10530
chr46830397768304613E072-9827
chr46833071468330762E07216274
chr46833127268331554E07216832
chr46833071468330762E07316274
chr46830252468302708E074-11732
chr46830369068303910E074-10530
chr46830397768304613E074-9827
chr46833127268331554E07416832
chr46833162368331730E07417183
chr46826808668268203E081-46237
chr46826759168267949E082-46491
chr46826808668268203E082-46237









Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr46831200668312191E082-2249