rs7683009

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0410 (12287/29930,GnomAD)
T=0394 (11493/29118,TOPMED)
T=0353 (1766/5008,1000G)
C==0458 (1765/3854,ALSPAC)
C==0478 (1773/3708,TWINSUK)
chr4:187776941 (GRCh38.p7) (4q35.2)
AD
GWASdb2
1   publication(s)
See rs on genome
2 Enhancers around
7 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.187776941C>T
GRCh37.p13 chr 4NC_000004.11:g.188698095C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.781T=0.219
1000GenomesAmericanSub694C=0.510T=0.490
1000GenomesEast AsianSub1008C=0.886T=0.114
1000GenomesEuropeSub1006C=0.501T=0.499
1000GenomesGlobalStudy-wide5008C=0.647T=0.353
1000GenomesSouth AsianSub978C=0.470T=0.530
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.458T=0.542
The Genome Aggregation DatabaseAfricanSub8716C=0.731T=0.269
The Genome Aggregation DatabaseAmericanSub834C=0.490T=0.510
The Genome Aggregation DatabaseEast AsianSub1614C=0.884T=0.116
The Genome Aggregation DatabaseEuropeSub18464C=0.502T=0.497
The Genome Aggregation DatabaseGlobalStudy-wide29930C=0.589T=0.410
The Genome Aggregation DatabaseOtherSub302C=0.520T=0.480
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.605T=0.394
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.478T=0.522
PMID Title Author Journal
22096494A novel, functional and replicable risk gene region for alcohol dependence identified by genome-wide association study.Zuo LPLoS One

P-Value

SNP ID p-value Traits Study
rs76830094.2E-05alcohol dependence22096494

eQTL of rs7683009 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7683009 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr4188703561188703687E0815466
chr4188703724188703826E0815629

Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr4188735921188736114E07037826
chr4188736143188736424E07038048
chr4188735921188736114E07137826
chr4188736143188736424E07138048
chr4188735921188736114E07437826
chr4188735921188736114E08237826
chr4188736143188736424E08238048