rs7709361

Homo sapiens
T>C
NDFIP1 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T==0328 (9816/29918,GnomAD)
T==0308 (8990/29118,TOPMED)
T==0334 (1672/5008,1000G)
T==0387 (1491/3854,ALSPAC)
T==0381 (1414/3708,TWINSUK)
chr5:142134289 (GRCh38.p7) (5q31.3)
AD
GWASdb2
1   publication(s)
See rs on genome
93 Enhancers around
10 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 5NC_000005.10:g.142134289T>C
GRCh37.p13 chr 5NC_000005.9:g.141513854T>C

Gene: NDFIP1, Nedd4 family interacting protein 1(plus strand)

Molecule type Change Amino acid[Codon] SO Term
NDFIP1 transcriptNM_030571.3:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.194C=0.806
1000GenomesAmericanSub694T=0.310C=0.690
1000GenomesEast AsianSub1008T=0.363C=0.637
1000GenomesEuropeSub1006T=0.380C=0.620
1000GenomesGlobalStudy-wide5008T=0.334C=0.666
1000GenomesSouth AsianSub978T=0.460C=0.540
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.387C=0.613
The Genome Aggregation DatabaseAfricanSub8708T=0.231C=0.769
The Genome Aggregation DatabaseAmericanSub836T=0.310C=0.690
The Genome Aggregation DatabaseEast AsianSub1606T=0.348C=0.652
The Genome Aggregation DatabaseEuropeSub18466T=0.373C=0.626
The Genome Aggregation DatabaseGlobalStudy-wide29918T=0.328C=0.671
The Genome Aggregation DatabaseOtherSub302T=0.280C=0.720
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.308C=0.691
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.381C=0.619
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs77093610.000608alcohol dependence20201924

eQTL of rs7709361 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7709361 in Fetal Brain

Probe ID Position Gene beta p-value
cg07392085chr5:141489673NDFIP1-0.03329377211070961.1316e-10

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr5141487642141487707E067-26147
chr5141500239141500327E067-13527
chr5141500451141500501E067-13353
chr5141507676141507760E067-6094
chr5141508433141508671E067-5183
chr5141524844141525300E06710990
chr5141525374141525437E06711520
chr5141546384141546452E06732530
chr5141494472141494553E068-19301
chr5141495582141495765E068-18089
chr5141495983141496059E068-17795
chr5141508433141508671E068-5183
chr5141508902141508952E068-4902
chr5141524844141525300E06810990
chr5141525374141525437E06811520
chr5141487642141487707E069-26147
chr5141492438141492491E069-21363
chr5141492653141492760E069-21094
chr5141494472141494553E069-19301
chr5141497314141497741E069-16113
chr5141499989141500071E069-13783
chr5141500239141500327E069-13527
chr5141500451141500501E069-13353
chr5141501853141501920E069-11934
chr5141507676141507760E069-6094
chr5141508902141508952E069-4902
chr5141524844141525300E06910990
chr5141536434141536602E06922580
chr5141536645141536984E06922791
chr5141546384141546452E06932530
chr5141500451141500501E070-13353
chr5141487642141487707E071-26147
chr5141495582141495765E071-18089
chr5141497314141497741E071-16113
chr5141497905141497989E071-15865
chr5141498114141498323E071-15531
chr5141500239141500327E071-13527
chr5141500451141500501E071-13353
chr5141501853141501920E071-11934
chr5141506900141507129E071-6725
chr5141507676141507760E071-6094
chr5141508433141508671E071-5183
chr5141536434141536602E07122580
chr5141536645141536984E07122791
chr5141546384141546452E07132530
chr5141487642141487707E072-26147
chr5141495582141495765E072-18089
chr5141497905141497989E072-15865
chr5141498114141498323E072-15531
chr5141498690141498908E072-14946
chr5141506900141507129E072-6725
chr5141507676141507760E072-6094
chr5141508902141508952E072-4902
chr5141536434141536602E07222580
chr5141536645141536984E07222791
chr5141546384141546452E07232530
chr5141494472141494553E073-19301
chr5141495582141495765E073-18089
chr5141495983141496059E073-17795
chr5141498114141498323E073-15531
chr5141498690141498908E073-14946
chr5141500239141500327E073-13527
chr5141500451141500501E073-13353
chr5141506900141507129E073-6725
chr5141507676141507760E073-6094
chr5141508902141508952E073-4902
chr5141487642141487707E074-26147
chr5141494472141494553E074-19301
chr5141497314141497741E074-16113
chr5141497905141497989E074-15865
chr5141498114141498323E074-15531
chr5141498690141498908E074-14946
chr5141506900141507129E074-6725
chr5141507676141507760E074-6094
chr5141508433141508671E074-5183
chr5141508902141508952E074-4902
chr5141525374141525437E07411520
chr5141525797141525946E07411943
chr5141546384141546452E07432530
chr5141486750141486865E081-26989
chr5141487055141487620E081-26234
chr5141487642141487707E081-26147
chr5141532042141532287E08118188
chr5141535529141535624E08121675
chr5141536434141536602E08122580
chr5141536645141536984E08122791
chr5141548955141549526E08135101
chr5141487055141487620E082-26234
chr5141507676141507760E082-6094
chr5141536434141536602E08222580
chr5141536645141536984E08222791
chr5141540701141540800E08226847
chr5141540875141541088E08227021










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr5141487834141490107E067-23747
chr5141487834141490107E068-23747
chr5141487834141490107E069-23747
chr5141487834141490107E070-23747
chr5141487834141490107E071-23747
chr5141487834141490107E072-23747
chr5141487834141490107E073-23747
chr5141487834141490107E074-23747
chr5141487834141490107E081-23747
chr5141487834141490107E082-23747