rs77109747

Organism: Homo sapiens

Alleles: G>A

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

A=0042 (1263/29980,GnomAD)
A=0032 (935/29118,TOPMED)
A=0085 (428/5008,1000G)
A=0026 (101/3854,ALSPAC)
A=0019 (72/3708,TWINSUK)

Position: chr1:34947470 (GRCh38.p7) (1p34.3)

Phenotype: ND

Dataset:

GWASCatalog

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 34 Enhancers around

Promoter: 41 Promoters around

Sequence Name	Change(s)
GRCh38.p7 chr 1	NC_000001.11:g.34947470G>A
GRCh37.p13 chr 1	NC_000001.10:g.35413071G>A

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.955	A=0.045
1000Genomes	American	Sub	694	G=0.970	A=0.030
1000Genomes	East Asian	Sub	1008	G=0.750	A=0.250
1000Genomes	Europe	Sub	1006	G=0.980	A=0.020
1000Genomes	Global	Study-wide	5008	G=0.915	A=0.085
1000Genomes	South Asian	Sub	978	G=0.920	A=0.080
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.974	A=0.026
The Genome Aggregation Database	African	Sub	8726	G=0.964	A=0.036
The Genome Aggregation Database	American	Sub	838	G=0.950	A=0.050
The Genome Aggregation Database	East Asian	Sub	1618	G=0.744	A=0.256
The Genome Aggregation Database	Europe	Sub	18496	G=0.974	A=0.025
The Genome Aggregation Database	Global	Study-wide	29980	G=0.957	A=0.042
The Genome Aggregation Database	Other	Sub	302	G=0.950	A=0.050
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.967	A=0.032
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.981	A=0.019

PMID	Title	Author	Journal
28440896	Genome-wide meta-analysis identifies a novel susceptibility signal at CACNA2D3 for nicotine dependence.	Yin X	Am J Med Genet B Neuropsychiatr Genet

SNP ID	p-value	Traits	Study
rs77109747	5E-07	nicotine dependence	28440896

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

There is no significant Hi-C chromatin interaction data for this SNP.

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr1	35375816	35375899	E067	-37172
chr1	35384026	35384249	E067	-28822
chr1	35384310	35384423	E067	-28648
chr1	35384554	35385028	E067	-28043
chr1	35396706	35396756	E067	-16315
chr1	35375816	35375899	E068	-37172
chr1	35384310	35384423	E068	-28648
chr1	35384554	35385028	E068	-28043
chr1	35385072	35385122	E068	-27949
chr1	35385494	35385548	E068	-27523
chr1	35446020	35446081	E068	32949
chr1	35449422	35449600	E068	36351
chr1	35373168	35373519	E070	-39552
chr1	35384026	35384249	E070	-28822
chr1	35384310	35384423	E070	-28648
chr1	35384554	35385028	E070	-28043
chr1	35366263	35366313	E073	-46758
chr1	35384026	35384249	E073	-28822
chr1	35384310	35384423	E073	-28648
chr1	35384554	35385028	E073	-28043
chr1	35385072	35385122	E073	-27949
chr1	35385494	35385548	E073	-27523
chr1	35392648	35392766	E073	-20305
chr1	35449422	35449600	E073	36351
chr1	35449422	35449600	E074	36351
chr1	35384026	35384249	E081	-28822
chr1	35384310	35384423	E081	-28648
chr1	35392933	35393012	E081	-20059
chr1	35393224	35393275	E081	-19796
chr1	35393703	35393770	E081	-19301
chr1	35449422	35449600	E081	36351
chr1	35393703	35393770	E082	-19301
chr1	35442148	35442219	E082	29077
chr1	35449422	35449600	E082	36351

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr1	35390215	35390325	E067	-22746
chr1	35394884	35395058	E067	-18013
chr1	35395074	35395390	E067	-17681
chr1	35395488	35396310	E067	-16761
chr1	35449785	35451272	E067	36714
chr1	35390215	35390325	E068	-22746
chr1	35390377	35390492	E068	-22579
chr1	35390524	35390745	E068	-22326
chr1	35395488	35396310	E068	-16761
chr1	35449785	35451272	E068	36714
chr1	35394884	35395058	E069	-18013
chr1	35395074	35395390	E069	-17681
chr1	35395488	35396310	E069	-16761
chr1	35449785	35451272	E069	36714
chr1	35394884	35395058	E070	-18013
chr1	35395074	35395390	E070	-17681
chr1	35395488	35396310	E070	-16761
chr1	35449785	35451272	E070	36714
chr1	35394884	35395058	E071	-18013
chr1	35395074	35395390	E071	-17681
chr1	35449785	35451272	E071	36714
chr1	35390215	35390325	E072	-22746
chr1	35390377	35390492	E072	-22579
chr1	35390524	35390745	E072	-22326
chr1	35394884	35395058	E072	-18013
chr1	35395074	35395390	E072	-17681
chr1	35395488	35396310	E072	-16761
chr1	35449785	35451272	E072	36714
chr1	35390215	35390325	E073	-22746
chr1	35390377	35390492	E073	-22579
chr1	35390524	35390745	E073	-22326
chr1	35394884	35395058	E073	-18013
chr1	35395074	35395390	E073	-17681
chr1	35395488	35396310	E073	-16761
chr1	35449785	35451272	E073	36714
chr1	35394466	35394759	E074	-18312
chr1	35449785	35451272	E074	36714
chr1	35394884	35395058	E082	-18013
chr1	35395074	35395390	E082	-17681
chr1	35395488	35396310	E082	-16761
chr1	35449785	35451272	E082	36714