rs7715618

Homo sapiens
A>C
GMCL1P1 : Non Coding Transcript Variant
Check p-value
SNV (Single Nucleotide Variation)
A==0221 (6644/29952,GnomAD)
A==0259 (7547/29118,TOPMED)
A==0188 (939/5008,1000G)
A==0145 (558/3854,ALSPAC)
A==0142 (526/3708,TWINSUK)
chr5:178185633 (GRCh38.p7) (5q35.3)
AD
GWASdb2
1   publication(s)
See rs on genome
99 Enhancers around
47 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 5NC_000005.10:g.178185633A>C
GRCh37.p13 chr 5NC_000005.9:g.177612634A>C

Gene: GMCL1P1, germ cell-less, spermatogenesis associated 1 pseudogene 1(minus strand)

Molecule type Change Amino acid[Codon] SO Term
Non-protein-coding transcriptsNR_003281.1:n.180...NR_003281.1:n.1800T>GT>GNon Coding Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.467C=0.533
1000GenomesAmericanSub694A=0.150C=0.850
1000GenomesEast AsianSub1008A=0.022C=0.978
1000GenomesEuropeSub1006A=0.127C=0.873
1000GenomesGlobalStudy-wide5008A=0.188C=0.812
1000GenomesSouth AsianSub978A=0.070C=0.930
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.145C=0.855
The Genome Aggregation DatabaseAfricanSub8704A=0.437C=0.563
The Genome Aggregation DatabaseAmericanSub834A=0.120C=0.880
The Genome Aggregation DatabaseEast AsianSub1616A=0.001C=0.999
The Genome Aggregation DatabaseEuropeSub18496A=0.146C=0.853
The Genome Aggregation DatabaseGlobalStudy-wide29952A=0.221C=0.778
The Genome Aggregation DatabaseOtherSub302A=0.100C=0.900
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.259C=0.740
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.142C=0.858
PMID Title Author Journal
21703634A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.Wang KSJ Psychiatr Res

P-Value

SNP ID p-value Traits Study
rs77156186.55E-05alcohol dependence21703634

eQTL of rs7715618 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7715618 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr5177578833177578896E067-33738
chr5177579529177579619E067-33015
chr5177633799177634006E06721165
chr5177656761177656845E06744127
chr5177656884177656946E06744250
chr5177657023177657131E06744389
chr5177657264177657318E06744630
chr5177657405177657459E06744771
chr5177657660177657762E06745026
chr5177578395177578494E068-34140
chr5177578551177578723E068-33911
chr5177578833177578896E068-33738
chr5177579529177579619E068-33015
chr5177633799177634006E06821165
chr5177634057177634818E06821423
chr5177634826177634972E06822192
chr5177657660177657762E06845026
chr5177661784177662447E06849150
chr5177662489177662570E06849855
chr5177579529177579619E069-33015
chr5177633799177634006E06921165
chr5177634057177634818E06921423
chr5177656761177656845E06944127
chr5177656884177656946E06944250
chr5177657023177657131E06944389
chr5177657264177657318E06944630
chr5177657405177657459E06944771
chr5177657660177657762E06945026
chr5177578551177578723E070-33911
chr5177578833177578896E070-33738
chr5177634826177634972E07022192
chr5177635074177635315E07022440
chr5177637079177637188E07024445
chr5177657023177657131E07044389
chr5177657264177657318E07044630
chr5177657405177657459E07044771
chr5177657660177657762E07045026
chr5177576659177576847E071-35787
chr5177576911177576991E071-35643
chr5177577013177577087E071-35547
chr5177579529177579619E071-33015
chr5177633799177634006E07121165
chr5177634057177634818E07121423
chr5177640320177640394E07127686
chr5177640479177640559E07127845
chr5177656761177656845E07144127
chr5177656884177656946E07144250
chr5177657023177657131E07144389
chr5177657264177657318E07144630
chr5177657405177657459E07144771
chr5177657660177657762E07145026
chr5177579529177579619E072-33015
chr5177657023177657131E07244389
chr5177657264177657318E07244630
chr5177657405177657459E07244771
chr5177657660177657762E07245026
chr5177661784177662447E07249150
chr5177662489177662570E07249855
chr5177570584177570645E073-41989
chr5177570686177570797E073-41837
chr5177570931177571213E073-41421
chr5177578395177578494E073-34140
chr5177578551177578723E073-33911
chr5177578833177578896E073-33738
chr5177579529177579619E073-33015
chr5177633799177634006E07321165
chr5177634057177634818E07321423
chr5177634826177634972E07322192
chr5177635074177635315E07322440
chr5177635362177635454E07322728
chr5177635660177635854E07323026
chr5177657405177657459E07344771
chr5177657660177657762E07345026
chr5177578833177578896E074-33738
chr5177579529177579619E074-33015
chr5177581683177581747E074-30887
chr5177633799177634006E07421165
chr5177634057177634818E07421423
chr5177634826177634972E07422192
chr5177635074177635315E07422440
chr5177657023177657131E07444389
chr5177657264177657318E07444630
chr5177657405177657459E07444771
chr5177657660177657762E07445026
chr5177660594177660644E07447960
chr5177661784177662447E07449150
chr5177662489177662570E07449855
chr5177633799177634006E08121165
chr5177634057177634818E08121423
chr5177645989177646080E08133355
chr5177657023177657131E08144389
chr5177657264177657318E08144630
chr5177657405177657459E08144771
chr5177657660177657762E08145026
chr5177581683177581747E082-30887
chr5177634826177634972E08222192
chr5177635074177635315E08222440
chr5177657405177657459E08244771
chr5177657660177657762E08245026










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr5177580272177580431E067-32203
chr5177580579177581256E067-31378
chr5177581258177581342E067-31292
chr5177630843177632916E06718209
chr5177658763177660458E06746129
chr5177580272177580431E068-32203
chr5177580579177581256E068-31378
chr5177581258177581342E068-31292
chr5177630843177632916E06818209
chr5177658763177660458E06846129
chr5177580272177580431E069-32203
chr5177580579177581256E069-31378
chr5177581258177581342E069-31292
chr5177630843177632916E06918209
chr5177658763177660458E06946129
chr5177580272177580431E070-32203
chr5177580579177581256E070-31378
chr5177581258177581342E070-31292
chr5177630843177632916E07018209
chr5177658763177660458E07046129
chr5177580272177580431E071-32203
chr5177580579177581256E071-31378
chr5177581258177581342E071-31292
chr5177630843177632916E07118209
chr5177658763177660458E07146129
chr5177580272177580431E072-32203
chr5177580579177581256E072-31378
chr5177581258177581342E072-31292
chr5177630843177632916E07218209
chr5177658763177660458E07246129
chr5177580272177580431E073-32203
chr5177580579177581256E073-31378
chr5177581258177581342E073-31292
chr5177630843177632916E07318209
chr5177658763177660458E07346129
chr5177580272177580431E074-32203
chr5177580579177581256E074-31378
chr5177581258177581342E074-31292
chr5177630843177632916E07418209
chr5177658763177660458E07446129
chr5177580272177580431E081-32203
chr5177580579177581256E081-31378
chr5177580272177580431E082-32203
chr5177580579177581256E082-31378
chr5177581258177581342E082-31292
chr5177630843177632916E08218209
chr5177658763177660458E08246129