rs7725091

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0241 (7233/29918,GnomAD)
T=0225 (6568/29118,TOPMED)
T=0193 (969/5008,1000G)
T=0283 (1091/3854,ALSPAC)
T=0269 (997/3708,TWINSUK)
chr5:10810492 (GRCh38.p7) (5p15.2)
AD
GWASdb2
1   publication(s)
See rs on genome
28 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 5NC_000005.10:g.10810492C>T
GRCh37.p13 chr 5NC_000005.9:g.10810604C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.846T=0.154
1000GenomesAmericanSub694C=0.820T=0.180
1000GenomesEast AsianSub1008C=0.938T=0.062
1000GenomesEuropeSub1006C=0.685T=0.315
1000GenomesGlobalStudy-wide5008C=0.807T=0.193
1000GenomesSouth AsianSub978C=0.740T=0.260
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.717T=0.283
The Genome Aggregation DatabaseAfricanSub8710C=0.838T=0.162
The Genome Aggregation DatabaseAmericanSub836C=0.780T=0.220
The Genome Aggregation DatabaseEast AsianSub1612C=0.949T=0.051
The Genome Aggregation DatabaseEuropeSub18458C=0.703T=0.296
The Genome Aggregation DatabaseGlobalStudy-wide29918C=0.758T=0.241
The Genome Aggregation DatabaseOtherSub302C=0.700T=0.300
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.774T=0.225
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.731T=0.269
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs77250918.9E-05alcohol consumption (maxi-drinks)24277619

eQTL of rs7725091 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7725091 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr51085655910856641E06745955
chr51085793610858018E06747332
chr51078862110788704E068-21900
chr51078894110789641E068-20963
chr51085655910856641E06845955
chr51078862110788704E069-21900
chr51078894110789641E069-20963
chr51085655910856641E06945955
chr51085793610858018E06947332
chr51085675010857883E07046146
chr51078862110788704E071-21900
chr51085471210854914E07144108
chr51085502310855269E07144419
chr51078862110788704E072-21900
chr51078894110789641E072-20963
chr51085655910856641E07245955
chr51085655910856641E07345955
chr51085793610858018E07347332
chr51078894110789641E074-20963
chr51085655910856641E07445955
chr51085675010857883E07446146
chr51085655910856641E08145955
chr51085675010857883E08146146
chr51085793610858018E08147332
chr51085846610858516E08147862
chr51085858410858654E08147980
chr51085675010857883E08246146
chr51085793610858018E08247332