rs7727185

Homo sapiens
A>G
None
Check p-value
SNV (Single Nucleotide Variation)
G=0195 (5852/29958,GnomAD)
G=0182 (5324/29118,TOPMED)
G=0129 (647/5008,1000G)
G=0166 (640/3854,ALSPAC)
G=0167 (620/3708,TWINSUK)
chr5:86881774 (GRCh38.p7) (5q14.3)
AD
GWASdb2
1   publication(s)
See rs on genome
44 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 5NC_000005.10:g.86881774A>G
GRCh37.p13 chr 5NC_000005.9:g.86177591A>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.753G=0.247
1000GenomesAmericanSub694A=0.910G=0.090
1000GenomesEast AsianSub1008A=0.999G=0.001
1000GenomesEuropeSub1006A=0.841G=0.159
1000GenomesGlobalStudy-wide5008A=0.871G=0.129
1000GenomesSouth AsianSub978A=0.900G=0.100
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.834G=0.166
The Genome Aggregation DatabaseAfricanSub8712A=0.764G=0.236
The Genome Aggregation DatabaseAmericanSub838A=0.880G=0.120
The Genome Aggregation DatabaseEast AsianSub1616A=0.998G=0.002
The Genome Aggregation DatabaseEuropeSub18490A=0.802G=0.197
The Genome Aggregation DatabaseGlobalStudy-wide29958A=0.804G=0.195
The Genome Aggregation DatabaseOtherSub302A=0.860G=0.140
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.817G=0.182
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.833G=0.167
PMID Title Author Journal
21529783A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications.Heath ACBiol Psychiatry

P-Value

SNP ID p-value Traits Study
rs77271851.4E-05alcoholism (heaviness of drinking)21529783

eQTL of rs7727185 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7727185 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr58615732586157745E067-19846
chr58615993686160199E067-17392
chr58616030686160410E067-17181
chr58616042586160475E067-17116
chr58616115286161599E068-15992
chr58616185686162267E068-15324
chr58616229686162440E068-15151
chr58615732586157745E069-19846
chr58615993686160199E069-17392
chr58616185686162267E069-15324
chr58616229686162440E069-15151
chr58615732586157745E070-19846
chr58616103786161087E070-16504
chr58616115286161599E070-15992
chr58616185686162267E070-15324
chr58616229686162440E070-15151
chr58620520386206038E07027612
chr58622498686225409E07047395
chr58615732586157745E071-19846
chr58615993686160199E071-17392
chr58616030686160410E071-17181
chr58616103786161087E071-16504
chr58616115286161599E071-15992
chr58616185686162267E071-15324
chr58615732586157745E072-19846
chr58615993686160199E072-17392
chr58615993686160199E073-17392
chr58616229686162440E073-15151
chr58616185686162267E074-15324
chr58616229686162440E074-15151
chr58615993686160199E081-17392
chr58616030686160410E081-17181
chr58616042586160475E081-17116
chr58616103786161087E081-16504
chr58616115286161599E081-15992
chr58616185686162267E081-15324
chr58616229686162440E081-15151
chr58615993686160199E082-17392
chr58616030686160410E082-17181
chr58616042586160475E082-17116
chr58616103786161087E082-16504
chr58616115286161599E082-15992
chr58616185686162267E082-15324
chr58616229686162440E082-15151