rs7729527

Homo sapiens
T>A / T>C
LOC107986399 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0114 (3434/29958,GnomAD)
C=0116 (3402/29118,TOPMED)
C=0087 (436/5008,1000G)
C=0076 (293/3854,ALSPAC)
C=0064 (237/3708,TWINSUK)
chr5:3616523 (GRCh38.p7) (5p15.33)
AD
GWASdb2
1   publication(s)
See rs on genome
5 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 5NC_000005.10:g.3616523T>A
GRCh38.p7 chr 5NC_000005.10:g.3616523T>C
GRCh37.p13 chr 5NC_000005.9:g.3616637T>A
GRCh37.p13 chr 5NC_000005.9:g.3616637T>C

Gene: LOC107986399, uncharacterized LOC107986399(plus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC107986399 transcriptXR_001742554.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.811C=0.189
1000GenomesAmericanSub694T=0.940C=0.060
1000GenomesEast AsianSub1008T=0.999C=0.001
1000GenomesEuropeSub1006T=0.901C=0.099
1000GenomesGlobalStudy-wide5008T=0.913C=0.087
1000GenomesSouth AsianSub978T=0.960C=0.040
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.924C=0.076
The Genome Aggregation DatabaseAfricanSub8718T=0.827C=0.173
The Genome Aggregation DatabaseAmericanSub838T=0.950C=0.05,
The Genome Aggregation DatabaseEast AsianSub1620T=1.000C=0.000
The Genome Aggregation DatabaseEuropeSub18480T=0.898C=0.101
The Genome Aggregation DatabaseGlobalStudy-wide29958T=0.885C=0.114
The Genome Aggregation DatabaseOtherSub302T=0.970C=0.03,
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.883C=0.116
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.936C=0.064
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs77295270.000612alcohol dependence21314694

eQTL of rs7729527 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7729527 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr545118584511961E0686314
chr545120244512146E0686480
chr545121724512441E0686628
chr545125384512758E0686994
chr545125384512758E0706994