rs7733625

Homo sapiens
G>T
RASGRF2 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0266 (32191/120636,ExAC)
T=0241 (7245/29954,GnomAD)
T=0258 (7528/29118,TOPMED)
G==0258 (3361/13006,GO-ESP)
T=0254 (1273/5008,1000G)
T=0291 (1121/3854,ALSPAC)
T=0290 (1074/3708,TWINSUK)
chr5:81086987 (GRCh38.p7) (5q14.1)
AD
GWASdb2
1   publication(s)
See rs on genome
85 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 5NC_000005.10:g.81086987G>T
GRCh37.p13 chr 5NC_000005.9:g.80382806G>T
RASGRF2 RefSeqGeneNG_030334.1:g.131299G>T

Gene: RASGRF2, Ras protein specific guanine nucleotide releasing factor 2(plus strand)

Molecule type Change Amino acid[Codon] SO Term
RASGRF2 transcriptNM_006909.2:c.N/AIntron Variant
RASGRF2 transcript variant X2XM_005248565.1:c.N/AIntron Variant
RASGRF2 transcript variant X1XM_017009682.1:c.N/AIntron Variant
RASGRF2 transcript variant X5XM_017009683.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.803T=0.197
1000GenomesAmericanSub694G=0.680T=0.320
1000GenomesEast AsianSub1008G=0.730T=0.270
1000GenomesEuropeSub1006G=0.712T=0.288
1000GenomesGlobalStudy-wide5008G=0.746T=0.254
1000GenomesSouth AsianSub978G=0.770T=0.230
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.709T=0.291
The Exome Aggregation ConsortiumAmericanSub21938G=0.736T=0.263
The Exome Aggregation ConsortiumAsianSub24754G=0.750T=0.249
The Exome Aggregation ConsortiumEuropeSub73044G=0.726T=0.273
The Exome Aggregation ConsortiumGlobalStudy-wide120636G=0.733T=0.266
The Exome Aggregation ConsortiumOtherSub900G=0.730T=0.270
The Genome Aggregation DatabaseAfricanSub8724G=0.794T=0.206
The Genome Aggregation DatabaseAmericanSub838G=0.680T=0.320
The Genome Aggregation DatabaseEast AsianSub1620G=0.730T=0.270
The Genome Aggregation DatabaseEuropeSub18472G=0.750T=0.249
The Genome Aggregation DatabaseGlobalStudy-wide29954G=0.758T=0.241
The Genome Aggregation DatabaseOtherSub300G=0.560T=0.440
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.741T=0.258
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.710T=0.290
PMID Title Author Journal
19581569Genome-wide association study of alcohol dependence.Treutlein JArch Gen Psychiatry

P-Value

SNP ID p-value Traits Study
rs77336254.22E-05alcohol dependence19581569

eQTL of rs7733625 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr5:80382806CTC-459I6.1ENSG00000251450.1G>T2.1183e-4134007Putamen_basal_ganglia

meQTL of rs7733625 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr58033951780339786E067-43020
chr58037644280376490E067-6316
chr58037655180376611E067-6195
chr58037669080377077E067-5729
chr58037728780377655E067-5151
chr58037794280378021E067-4785
chr58034137480341446E068-41360
chr58034366980343749E068-39057
chr58034386780344025E068-38781
chr58037644280376490E068-6316
chr58037655180376611E068-6195
chr58037669080377077E068-5729
chr58037728780377655E068-5151
chr58037794280378021E068-4785
chr58041783180417931E06835025
chr58041796680418347E06835160
chr58034366980343749E069-39057
chr58034386780344025E069-38781
chr58034541080345594E069-37212
chr58036117780361597E069-21209
chr58037644280376490E069-6316
chr58037655180376611E069-6195
chr58037669080377077E069-5729
chr58037794280378021E069-4785
chr58040681080406979E07024004
chr58040904780409139E07026241
chr58041688980417132E07034083
chr58041720080417259E07034394
chr58041728580417380E07034479
chr58041783180417931E07035025
chr58041796680418347E07035160
chr58034137480341446E071-41360
chr58034366980343749E071-39057
chr58034386780344025E071-38781
chr58034582880345888E071-36918
chr58037644280376490E071-6316
chr58037655180376611E071-6195
chr58037669080377077E071-5729
chr58037794280378021E071-4785
chr58040681080406979E07124004
chr58041720080417259E07134394
chr58041728580417380E07134479
chr58034366980343749E072-39057
chr58034386780344025E072-38781
chr58034582880345888E072-36918
chr58035999180360108E072-22698
chr58036015380360207E072-22599
chr58036044880360682E072-22124
chr58036117780361597E072-21209
chr58037644280376490E072-6316
chr58037655180376611E072-6195
chr58037669080377077E072-5729
chr58037794280378021E072-4785
chr58034366980343749E073-39057
chr58036117780361597E073-21209
chr58037644280376490E073-6316
chr58037655180376611E073-6195
chr58037669080377077E073-5729
chr58041783180417931E07335025
chr58041796680418347E07335160
chr58033951780339786E074-43020
chr58034137480341446E074-41360
chr58034366980343749E074-39057
chr58034386780344025E074-38781
chr58034541080345594E074-37212
chr58034582880345888E074-36918
chr58035999180360108E074-22698
chr58036015380360207E074-22599
chr58036044880360682E074-22124
chr58036117780361597E074-21209
chr58037644280376490E074-6316
chr58037655180376611E074-6195
chr58037669080377077E074-5729
chr58037728780377655E074-5151
chr58037794280378021E074-4785
chr58038878880388893E0745982
chr58041688980417132E08134083
chr58041720080417259E08134394
chr58041728580417380E08134479
chr58043004080430098E08147234
chr58041688980417132E08234083
chr58041720080417259E08234394
chr58041728580417380E08234479
chr58041783180417931E08235025
chr58041796680418347E08235160