rs77409651

Homo sapiens
T>A
VTI1A : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0053 (1610/29976,GnomAD)
A=0052 (1526/29118,TOPMED)
A=0130 (649/5008,1000G)
A=0022 (84/3854,ALSPAC)
A=0022 (81/3708,TWINSUK)
chr10:112642215 (GRCh38.p7) (10q25.2)
CD
GWASdb2
1   publication(s)
See rs on genome
57 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 10NC_000010.11:g.112642215T>A
GRCh37.p13 chr 10NC_000010.10:g.114401974T>A

Gene: VTI1A, vesicle transport through interaction with t-SNAREs 1A(plus strand)

Molecule type Change Amino acid[Codon] SO Term
VTI1A transcript variant 1NM_001318203.1:c.N/AIntron Variant
VTI1A transcript variant 3NM_001318205.1:c.N/AIntron Variant
VTI1A transcript variant 2NM_145206.3:c.N/AIntron Variant
VTI1A transcript variant 4NR_134521.1:n.N/AGenic Downstream Transcript Variant
VTI1A transcript variant 5NR_134522.1:n.N/AGenic Downstream Transcript Variant
VTI1A transcript variant 6NR_134523.1:n.N/AGenic Downstream Transcript Variant
VTI1A transcript variant X8XM_005269544.4:c.N/AIntron Variant
VTI1A transcript variant X10XM_005269545.4:c.N/AIntron Variant
VTI1A transcript variant X11XM_005269546.3:c.N/AIntron Variant
VTI1A transcript variant X13XM_005269547.4:c.N/AIntron Variant
VTI1A transcript variant X6XM_006717637.2:c.N/AIntron Variant
VTI1A transcript variant X3XM_011539328.2:c.N/AIntron Variant
VTI1A transcript variant X4XM_011539330.2:c.N/AIntron Variant
VTI1A transcript variant X12XM_011539331.2:c.N/AIntron Variant
VTI1A transcript variant X1XM_017015745.1:c.N/AIntron Variant
VTI1A transcript variant X2XM_017015746.1:c.N/AIntron Variant
VTI1A transcript variant X7XM_017015747.1:c.N/AIntron Variant
VTI1A transcript variant X9XM_017015748.1:c.N/AIntron Variant
VTI1A transcript variant X14XM_011539333.2:c.N/AGenic Downstream Transcript Variant
VTI1A transcript variant X5XR_001747027.1:n.N/AIntron Variant
VTI1A transcript variant X15XR_001747028.1:n.N/AGenic Downstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.958A=0.042
1000GenomesAmericanSub694T=0.770A=0.230
1000GenomesEast AsianSub1008T=0.687A=0.313
1000GenomesEuropeSub1006T=0.985A=0.015
1000GenomesGlobalStudy-wide5008T=0.870A=0.130
1000GenomesSouth AsianSub978T=0.890A=0.110
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.978A=0.022
The Genome Aggregation DatabaseAfricanSub8726T=0.948A=0.052
The Genome Aggregation DatabaseAmericanSub836T=0.740A=0.260
The Genome Aggregation DatabaseEast AsianSub1608T=0.726A=0.274
The Genome Aggregation DatabaseEuropeSub18504T=0.973A=0.026
The Genome Aggregation DatabaseGlobalStudy-wide29976T=0.946A=0.053
The Genome Aggregation DatabaseOtherSub302T=0.990A=0.010
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.947A=0.052
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.978A=0.022
PMID Title Author Journal
23958962Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.Gelernter JMol Psychiatry

P-Value

SNP ID p-value Traits Study
rs774096510.000191cocaine dependence23958962

eQTL of rs77409651 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs77409651 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr10114383620114384073E067-17901
chr10114384198114384250E067-17724
chr10114391139114391221E067-10753
chr10114391261114391704E067-10270
chr10114397679114397990E067-3984
chr10114383307114383379E068-18595
chr10114383497114383547E068-18427
chr10114383620114384073E068-17901
chr10114384198114384250E068-17724
chr10114430437114430477E06828463
chr10114430531114430673E06828557
chr10114437433114438318E06835459
chr10114382609114382841E069-19133
chr10114383030114383070E069-18904
chr10114383109114383209E069-18765
chr10114383307114383379E069-18595
chr10114383497114383547E069-18427
chr10114383620114384073E069-17901
chr10114384198114384250E069-17724
chr10114432123114432383E07030149
chr10114437433114438318E07035459
chr10114438346114439019E07036372
chr10114383109114383209E071-18765
chr10114383307114383379E071-18595
chr10114383497114383547E071-18427
chr10114383620114384073E071-17901
chr10114384198114384250E071-17724
chr10114384424114384653E071-17321
chr10114391139114391221E071-10753
chr10114391261114391704E071-10270
chr10114391727114392060E071-9914
chr10114392310114392360E071-9614
chr10114408880114409017E0716906
chr10114430531114430673E07128557
chr10114430918114431090E07128944
chr10114437433114438318E07135459
chr10114438346114439019E07136372
chr10114391139114391221E072-10753
chr10114391261114391704E072-10270
chr10114391727114392060E072-9914
chr10114397679114397990E072-3984
chr10114398065114398158E072-3816
chr10114430437114430477E07228463
chr10114430531114430673E07228557
chr10114382609114382841E074-19133
chr10114383030114383070E074-18904
chr10114383109114383209E074-18765
chr10114383307114383379E074-18595
chr10114383497114383547E074-18427
chr10114383620114384073E074-17901
chr10114384198114384250E074-17724
chr10114391139114391221E074-10753
chr10114391261114391704E074-10270
chr10114391727114392060E074-9914
chr10114397679114397990E074-3984
chr10114412982114413032E07411008
chr10114437433114438318E07435459