rs7761742

Homo sapiens
T>C
MEI4 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T==0481 (14377/29836,GnomAD)
C=0452 (13174/29118,TOPMED)
C=0478 (2392/5008,1000G)
T==0387 (1490/3854,ALSPAC)
T==0380 (1410/3708,TWINSUK)
chr6:77710715 (GRCh38.p7) (6q14.1)
OD
GWASdb2
1   publication(s)
See rs on genome
0 Enhancer around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 6NC_000006.12:g.77710715T>C
GRCh37.p13 chr 6NC_000006.11:g.78420432T>C

Gene: MEI4, meiotic double-stranded break formation protein 4(plus strand)

Molecule type Change Amino acid[Codon] SO Term
MEI4 transcript variant 1NM_001282136.2:c.N/AIntron Variant
MEI4 transcript variant 2NM_001322247.1:c.N/AIntron Variant
MEI4 transcript variant X1XM_017010155.1:c.N/AIntron Variant
MEI4 transcript variant X2XM_005248774.3:c.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.784C=0.216
1000GenomesAmericanSub694T=0.480C=0.520
1000GenomesEast AsianSub1008T=0.436C=0.564
1000GenomesEuropeSub1006T=0.341C=0.659
1000GenomesGlobalStudy-wide5008T=0.522C=0.478
1000GenomesSouth AsianSub978T=0.470C=0.530
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.387C=0.613
The Genome Aggregation DatabaseAfricanSub8692T=0.732C=0.268
The Genome Aggregation DatabaseAmericanSub834T=0.420C=0.580
The Genome Aggregation DatabaseEast AsianSub1612T=0.423C=0.577
The Genome Aggregation DatabaseEuropeSub18396T=0.373C=0.626
The Genome Aggregation DatabaseGlobalStudy-wide29836T=0.481C=0.518
The Genome Aggregation DatabaseOtherSub302T=0.340C=0.660
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.547C=0.452
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.380C=0.620
PMID Title Author Journal
23183491Genome-wide association study identifies a potent locus associated with human opioid sensitivity.Nishizawa DMol Psychiatry

P-Value

SNP ID p-value Traits Study
rs77617421.66E-05Opioid sensitivity23183491

eQTL of rs7761742 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7761742 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.