rs7765319

Homo sapiens
C>A / C>T
TSG1 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C==0162 (4858/29864,GnomAD)
C==0141 (4117/29118,TOPMED)
C==0109 (547/5008,1000G)
C==0197 (761/3854,ALSPAC)
C==0206 (763/3708,TWINSUK)
chr6:93763439 (GRCh38.p7) (6q16.1)
AD
GWASdb2
1   publication(s)
See rs on genome
23 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 6NC_000006.12:g.93763439C>A
GRCh38.p7 chr 6NC_000006.12:g.93763439C>T
GRCh37.p13 chr 6NC_000006.11:g.94473157C>A
GRCh37.p13 chr 6NC_000006.11:g.94473157C>T

Gene: TSG1, tumor suppressor TSG1(plus strand)

Molecule type Change Amino acid[Codon] SO Term
TSG1 transcriptNR_015362.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.052T=0.948
1000GenomesAmericanSub694C=0.120T=0.880
1000GenomesEast AsianSub1008C=0.039T=0.961
1000GenomesEuropeSub1006C=0.203T=0.797
1000GenomesGlobalStudy-wide5008C=0.109T=0.891
1000GenomesSouth AsianSub978C=0.160T=0.840
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.197T=0.803
The Genome Aggregation DatabaseAfricanSub8718C=0.078T=0.922
The Genome Aggregation DatabaseAmericanSub828C=0.100T=0.90,
The Genome Aggregation DatabaseEast AsianSub1616C=0.033T=0.967
The Genome Aggregation DatabaseEuropeSub18400C=0.214T=0.785
The Genome Aggregation DatabaseGlobalStudy-wide29864C=0.162T=0.837
The Genome Aggregation DatabaseOtherSub302C=0.300T=0.70,
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.141T=0.858
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.206T=0.794
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs77653190.000682alcohol dependence20201924

eQTL of rs7765319 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7765319 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr677850197785159E067-1542
chr677852727785326E067-1375
chr678161387816196E06729437
chr678278697827990E06741168
chr677641107764464E070-22237
chr677645847764646E070-22055
chr677659637766152E070-20549
chr677736687773839E070-12862
chr677743057774397E070-12304
chr678161387816196E07029437
chr677850197785159E073-1542
chr677852727785326E073-1375
chr677587077759031E081-27670
chr677613787761588E081-25113
chr677618297761901E081-24800
chr677645847764646E081-22055
chr677850197785159E081-1542
chr677868537787936E081152
chr677618297761901E082-24800
chr677638107763885E082-22816
chr677641107764464E082-22237
chr677857047786829E0820
chr677868537787936E082152