rs7777391

Homo sapiens
A>G
None
Check p-value
SNV (Single Nucleotide Variation)
A==0387 (11587/29910,GnomAD)
A==0425 (12375/29118,TOPMED)
G=0476 (2385/5008,1000G)
A==0392 (1510/3854,ALSPAC)
A==0363 (1345/3708,TWINSUK)
chr7:117981823 (GRCh38.p7) (7q31.31)
ND
GWASdb2
3   publication(s)
See rs on genome
68 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 7NC_000007.14:g.117981823A>G
GRCh37.p13 chr 7NC_000007.13:g.117621877A>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.387G=0.613
1000GenomesAmericanSub694A=0.600G=0.400
1000GenomesEast AsianSub1008A=0.807G=0.193
1000GenomesEuropeSub1006A=0.375G=0.625
1000GenomesGlobalStudy-wide5008A=0.524G=0.476
1000GenomesSouth AsianSub978A=0.520G=0.480
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.392G=0.608
The Genome Aggregation DatabaseAfricanSub8702A=0.391G=0.609
The Genome Aggregation DatabaseAmericanSub838A=0.600G=0.400
The Genome Aggregation DatabaseEast AsianSub1610A=0.827G=0.173
The Genome Aggregation DatabaseEuropeSub18458A=0.336G=0.663
The Genome Aggregation DatabaseGlobalStudy-wide29910A=0.387G=0.612
The Genome Aggregation DatabaseOtherSub302A=0.480G=0.520
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.425G=0.575
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.363G=0.637
PMID Title Author Journal
22096494A novel, functional and replicable risk gene region for alcohol dependence identified by genome-wide association study.Zuo LPLoS One
20202923A genome-wide association study of alcohol dependence.Bierut LJProc Natl Acad Sci U S A
22488850Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence.Zuo LAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs77773910.0000003alcohol dependence22096494
rs77773910.0000025alcohol and nictotine co-dependence22488850
rs77773910.0000027alcohol dependence20202923

eQTL of rs7777391 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7777391 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr7117644450117644601E06822573
chr7117595224117595299E070-26578
chr7117595339117595379E070-26498
chr7117603045117603137E070-18740
chr7117603303117603656E070-18221
chr7117603670117604295E070-17582
chr7117643369117644042E07021492
chr7117644173117644279E07022296
chr7117644355117644395E07022478
chr7117644450117644601E07022573
chr7117645142117645605E07023265
chr7117646392117646442E07024515
chr7117646868117647170E07024991
chr7117603303117603656E071-18221
chr7117603670117604295E071-17582
chr7117633426117634067E07111549
chr7117643369117644042E07121492
chr7117645142117645605E07123265
chr7117669618117670490E07147741
chr7117633426117634067E07211549
chr7117634140117634200E07212263
chr7117645142117645605E07223265
chr7117669618117670490E07247741
chr7117669618117670490E07347741
chr7117603045117603137E074-18740
chr7117603303117603656E074-18221
chr7117603670117604295E074-17582
chr7117638816117639102E08116939
chr7117639139117639213E08117262
chr7117639337117639433E08117460
chr7117639615117639772E08117738
chr7117640218117640318E08118341
chr7117640350117640419E08118473
chr7117640481117640872E08118604
chr7117640907117641063E08119030
chr7117641071117641206E08119194
chr7117642994117643137E08121117
chr7117643170117643355E08121293
chr7117643369117644042E08121492
chr7117644173117644279E08122296
chr7117644355117644395E08122478
chr7117644450117644601E08122573
chr7117645142117645605E08123265
chr7117646392117646442E08124515
chr7117646868117647170E08124991
chr7117647216117647555E08125339
chr7117650573117650658E08128696
chr7117650982117651032E08129105
chr7117651569117651632E08129692
chr7117651855117651905E08129978
chr7117652164117652232E08130287
chr7117652284117652779E08130407
chr7117653042117653135E08131165
chr7117653423117653556E08131546
chr7117653653117653801E08131776
chr7117664417117664467E08142540
chr7117668330117668665E08146453
chr7117669618117670490E08147741
chr7117640481117640872E08218604
chr7117640907117641063E08219030
chr7117641071117641206E08219194
chr7117644173117644279E08222296
chr7117644355117644395E08222478
chr7117644450117644601E08222573
chr7117645142117645605E08223265
chr7117646868117647170E08224991
chr7117647216117647555E08225339
chr7117669618117670490E08247741