rs7777468

Homo sapiens
C>T
SLC37A3 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0153 (4594/29964,GnomAD)
T=0176 (5151/29118,TOPMED)
T=0169 (848/5008,1000G)
T=0099 (381/3854,ALSPAC)
T=0096 (356/3708,TWINSUK)
chr7:140371515 (GRCh38.p7) (7q34)
AD
GWASdb2
1   publication(s)
See rs on genome
97 Enhancers around
12 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 7NC_000007.14:g.140371515C>T
GRCh37.p13 chr 7NC_000007.13:g.140071315C>T

Gene: SLC37A3, solute carrier family 37 member 3(minus strand)

Molecule type Change Amino acid[Codon] SO Term
SLC37A3 transcript variant 3NM_001287498.1:c.N/AIntron Variant
SLC37A3 transcript variant 2NM_032295.3:c.N/AIntron Variant
SLC37A3 transcript variant 1NM_207113.2:c.N/AIntron Variant
SLC37A3 transcript variant X2XM_011516626.2:c.N/AIntron Variant
SLC37A3 transcript variant X3XM_011516627.2:c.N/AIntron Variant
SLC37A3 transcript variant X1XM_017012712.1:c.N/AIntron Variant
SLC37A3 transcript variant X4XM_017012713.1:c.N/AIntron Variant
SLC37A3 transcript variant X5XM_017012714.1:c.N/AIntron Variant
SLC37A3 transcript variant X6XM_017012715.1:c.N/AIntron Variant
SLC37A3 transcript variant X7XM_017012716.1:c.N/AIntron Variant
SLC37A3 transcript variant X8XM_017012717.1:c.N/AIntron Variant
SLC37A3 transcript variant X10XM_017012718.1:c.N/AIntron Variant
SLC37A3 transcript variant X9XR_927543.2:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.707T=0.293
1000GenomesAmericanSub694C=0.910T=0.090
1000GenomesEast AsianSub1008C=0.898T=0.102
1000GenomesEuropeSub1006C=0.896T=0.104
1000GenomesGlobalStudy-wide5008C=0.831T=0.169
1000GenomesSouth AsianSub978C=0.800T=0.200
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.901T=0.099
The Genome Aggregation DatabaseAfricanSub8716C=0.723T=0.277
The Genome Aggregation DatabaseAmericanSub838C=0.930T=0.070
The Genome Aggregation DatabaseEast AsianSub1616C=0.907T=0.093
The Genome Aggregation DatabaseEuropeSub18492C=0.896T=0.103
The Genome Aggregation DatabaseGlobalStudy-wide29964C=0.846T=0.153
The Genome Aggregation DatabaseOtherSub302C=0.840T=0.160
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.823T=0.176
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.904T=0.096
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs77774680.000065alcohol dependence20201924
rs77774680.0000651alcoholismpha002892

eQTL of rs7777468 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7777468 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr7140025459140025669E067-45646
chr7140025698140025906E067-45409
chr7140029703140029894E067-41421
chr7140030053140030188E067-41127
chr7140030328140030378E067-40937
chr7140030430140030843E067-40472
chr7140034102140034152E067-37163
chr7140034220140034264E067-37051
chr7140034267140034955E067-36360
chr7140035039140035217E067-36098
chr7140048981140049603E067-21712
chr7140025459140025669E068-45646
chr7140029703140029894E068-41421
chr7140030053140030188E068-41127
chr7140030328140030378E068-40937
chr7140033344140033423E068-37892
chr7140033558140033650E068-37665
chr7140034102140034152E068-37163
chr7140034220140034264E068-37051
chr7140034267140034955E068-36360
chr7140035039140035217E068-36098
chr7140048009140048563E068-22752
chr7140058233140058889E068-12426
chr7140025459140025669E069-45646
chr7140025698140025906E069-45409
chr7140025923140026707E069-44608
chr7140029703140029894E069-41421
chr7140030053140030188E069-41127
chr7140030328140030378E069-40937
chr7140033137140033281E069-38034
chr7140033344140033423E069-37892
chr7140033558140033650E069-37665
chr7140034102140034152E069-37163
chr7140034220140034264E069-37051
chr7140034267140034955E069-36360
chr7140035039140035217E069-36098
chr7140089813140089863E06918498
chr7140089993140090143E06918678
chr7140090194140090327E06918879
chr7140090331140091024E06919016
chr7140030430140030843E070-40472
chr7140031058140031186E070-40129
chr7140048981140049603E070-21712
chr7140029703140029894E071-41421
chr7140030053140030188E071-41127
chr7140030328140030378E071-40937
chr7140033137140033281E071-38034
chr7140033344140033423E071-37892
chr7140033558140033650E071-37665
chr7140034102140034152E071-37163
chr7140034220140034264E071-37051
chr7140034267140034955E071-36360
chr7140035039140035217E071-36098
chr7140035698140035752E071-35563
chr7140089662140089774E07118347
chr7140089813140089863E07118498
chr7140089993140090143E07118678
chr7140090194140090327E07118879
chr7140090331140091024E07119016
chr7140091040140091234E07119725
chr7140091518140091721E07120203
chr7140091738140091904E07120423
chr7140091923140092047E07120608
chr7140096233140096639E07124918
chr7140096710140096798E07125395
chr7140097126140097166E07125811
chr7140025459140025669E072-45646
chr7140025698140025906E072-45409
chr7140025923140026707E072-44608
chr7140029703140029894E072-41421
chr7140034220140034264E072-37051
chr7140034267140034955E072-36360
chr7140035039140035217E072-36098
chr7140035698140035752E072-35563
chr7140025459140025669E073-45646
chr7140025698140025906E073-45409
chr7140025923140026707E073-44608
chr7140029703140029894E073-41421
chr7140030053140030188E073-41127
chr7140030430140030843E073-40472
chr7140048981140049603E073-21712
chr7140085021140085065E07313706
chr7140085068140085300E07313753
chr7140025459140025669E074-45646
chr7140025698140025906E074-45409
chr7140030053140030188E074-41127
chr7140030328140030378E074-40937
chr7140034102140034152E074-37163
chr7140034220140034264E074-37051
chr7140034267140034955E074-36360
chr7140035698140035752E074-35563
chr7140048981140049603E074-21712
chr7140030328140030378E081-40937
chr7140096710140096798E08125395
chr7140030053140030188E082-41127
chr7140030328140030378E082-40937
chr7140030430140030843E082-40472










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr7140097350140099043E06726035
chr7140097350140099043E06826035
chr7140097350140099043E06926035
chr7140097246140097331E07025931
chr7140097350140099043E07026035
chr7140097350140099043E07126035
chr7140097350140099043E07226035
chr7140097350140099043E07326035
chr7140097350140099043E07426035
chr7140103457140104903E07432142
chr7140097246140097331E08225931
chr7140097350140099043E08226035