rs7806781

Homo sapiens
C>A / C>T
TMEM168 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0201 (6043/29946,GnomAD)
T=0211 (1058/5008,1000G)
T=0183 (704/3854,ALSPAC)
T=0191 (707/3708,TWINSUK)
chr7:112780017 (GRCh38.p7) (7q31.1)
AD
GWASdb2
1   publication(s)
See rs on genome
0 Enhancer around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 7NC_000007.14:g.112780017C>A
GRCh38.p7 chr 7NC_000007.14:g.112780017C>T
GRCh37.p13 chr 7NC_000007.13:g.112420072C>A
GRCh37.p13 chr 7NC_000007.13:g.112420072C>T

Gene: TMEM168, transmembrane protein 168(minus strand)

Molecule type Change Amino acid[Codon] SO Term
TMEM168 transcript variant 1NM_001287497.1:c.N/AIntron Variant
TMEM168 transcript variant 2NM_022484.5:c.N/AIntron Variant
TMEM168 transcript variant 3NR_109840.1:n.N/AIntron Variant
TMEM168 transcript variant X1XM_017012523.1:c.N/AIntron Variant
TMEM168 transcript variant X4XM_017012524.1:c.N/AIntron Variant
TMEM168 transcript variant X5XM_017012525.1:c.N/AIntron Variant
TMEM168 transcript variant X2XR_001744853.1:n.N/AIntron Variant
TMEM168 transcript variant X3XR_001744854.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.706T=0.294
1000GenomesAmericanSub694C=0.800T=0.200
1000GenomesEast AsianSub1008C=0.932T=0.068
1000GenomesEuropeSub1006C=0.781T=0.219
1000GenomesGlobalStudy-wide5008C=0.789T=0.211
1000GenomesSouth AsianSub978C=0.750T=0.250
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.817T=0.183
The Genome Aggregation DatabaseAfricanSub8712C=0.739T=0.261
The Genome Aggregation DatabaseAmericanSub838C=0.800T=0.200
The Genome Aggregation DatabaseEast AsianSub1618C=0.926T=0.074
The Genome Aggregation DatabaseEuropeSub18476C=0.816T=0.183
The Genome Aggregation DatabaseGlobalStudy-wide29946C=0.798T=0.201
The Genome Aggregation DatabaseOtherSub302C=0.670T=0.330
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.809T=0.191
PMID Title Author Journal
21529783A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications.Heath ACBiol Psychiatry

P-Value

SNP ID p-value Traits Study
rs78067816.6E-05alcoholism (heaviness of drinking)21529783

eQTL of rs7806781 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr7:112420072TMEM168ENSG00000146802.8C>T1.8134e-4-10575Nucleus_accumbens_basal_ganglia

meQTL of rs7806781 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.