rs7821178

Homo sapiens
C>A / C>G / C>T
None
Check p-value
SNV (Single Nucleotide Variation)
A=0379 (11327/29824,GnomAD)
A=0422 (12291/29118,TOPMED)
A=0461 (2310/5008,1000G)
chr8:77181601 (GRCh38.p7) (8q21.13)
AD
GWASdb2
5   publication(s)
See rs on genome
0 Enhancer around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.77181601C>A
GRCh38.p7 chr 8NC_000008.11:g.77181601C>G
GRCh38.p7 chr 8NC_000008.11:g.77181601C>T
GRCh37.p13 chr 8NC_000008.10:g.78093837C>A
GRCh37.p13 chr 8NC_000008.10:g.78093837C>G
GRCh37.p13 chr 8NC_000008.10:g.78093837C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.439A=0.561
1000GenomesAmericanSub694C=0.600A=0.40,
1000GenomesEast AsianSub1008C=0.504A=0.466
1000GenomesEuropeSub1006C=0.663A=0.336
1000GenomesGlobalStudy-wide5008C=0.532A=0.461
1000GenomesSouth AsianSub978C=0.510A=0.49,
The Genome Aggregation DatabaseAfricanSub8686C=0.499T=0.000
The Genome Aggregation DatabaseAmericanSub834C=0.610T=0.00,
The Genome Aggregation DatabaseEast AsianSub1572C=0.511T=0.039
The Genome Aggregation DatabaseEuropeSub18430C=0.681T=0.000
The Genome Aggregation DatabaseGlobalStudy-wide29824C=0.618T=0.002
The Genome Aggregation DatabaseOtherSub302C=0.690T=0.00,
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.577A=0.422
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res
22433456Reproductive aging-associated common genetic variants and the risk of breast cancer.He CBreast Cancer Res
27044414Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort.Bonilla CBMC Med
21102462Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.Elks CENat Genet
21931568Genome-wide association study identifies four loci associated with eruption of permanent teeth.Geller FPLoS Genet

P-Value

SNP ID p-value Traits Study
rs78211780.000494alcohol dependence20201924

eQTL of rs7821178 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7821178 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.