rs7825180

Homo sapiens
T>A
SNX16 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T==0343 (10253/29868,GnomAD)
T==0360 (10508/29118,TOPMED)
T==0397 (1986/5008,1000G)
T==0333 (1282/3854,ALSPAC)
T==0320 (1188/3708,TWINSUK)
chr8:81811756 (GRCh38.p7) (8q21.13)
AD
GWASdb2
1   publication(s)
See rs on genome
94 Enhancers around
39 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.81811756T>A
GRCh37.p13 chr 8NC_000008.10:g.82723991T>A

Gene: SNX16, sorting nexin 16(minus strand)

Molecule type Change Amino acid[Codon] SO Term
SNX16 transcript variant 1NM_022133.3:c.N/AIntron Variant
SNX16 transcript variant 2NM_152836.2:c.N/AIntron Variant
SNX16 transcript variant 3NM_152837.2:c.N/AIntron Variant
SNX16 transcript variant X1XM_005251282.4:c.N/AIntron Variant
SNX16 transcript variant X2XM_005251283.2:c.N/AIntron Variant
SNX16 transcript variant X3XM_011517574.2:c.N/AIntron Variant
SNX16 transcript variant X3XR_001745572.1:n.N/AIntron Variant
SNX16 transcript variant X5XR_001745573.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.376A=0.624
1000GenomesAmericanSub694T=0.390A=0.610
1000GenomesEast AsianSub1008T=0.597A=0.403
1000GenomesEuropeSub1006T=0.327A=0.673
1000GenomesGlobalStudy-wide5008T=0.397A=0.603
1000GenomesSouth AsianSub978T=0.290A=0.710
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.333A=0.667
The Genome Aggregation DatabaseAfricanSub8700T=0.367A=0.633
The Genome Aggregation DatabaseAmericanSub834T=0.320A=0.680
The Genome Aggregation DatabaseEast AsianSub1606T=0.630A=0.370
The Genome Aggregation DatabaseEuropeSub18428T=0.307A=0.692
The Genome Aggregation DatabaseGlobalStudy-wide29868T=0.343A=0.656
The Genome Aggregation DatabaseOtherSub300T=0.360A=0.640
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.360A=0.639
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.320A=0.680
PMID Title Author Journal
23743675A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.Kapoor MHum Genet

P-Value

SNP ID p-value Traits Study
rs78251803.17E-05alcohol consumption23743675

eQTL of rs7825180 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7825180 in Fetal Brain

Probe ID Position Gene beta p-value
cg17211192chr8:82754475SNX160.06482078975211631.1897e-26
cg27398817chr8:82754497SNX160.03831897822715894.2717e-15
cg23324259chr8:82754387SNX160.01768749997089576.1498e-14

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr88272692182727044E0672930
chr88272708482727145E0673093
chr88272739782727713E0673406
chr88275141582751459E06727424
chr88275155182751632E06727560
chr88275169382751743E06727702
chr88275176982751905E06727778
chr88275192082751978E06727929
chr88275205182752101E06728060
chr88275213682752286E06728145
chr88275242482752500E06728433
chr88275252382752586E06728532
chr88274913582749745E06825144
chr88275040382750493E06826412
chr88275055782750622E06826566
chr88275073382750913E06826742
chr88275118682751259E06827195
chr88275141582751459E06827424
chr88275155182751632E06827560
chr88275169382751743E06827702
chr88275242482752500E06828433
chr88275252382752586E06828532
chr88275264882752702E06828657
chr88275205182752101E06928060
chr88275213682752286E06928145
chr88275242482752500E06928433
chr88275252382752586E06928532
chr88275264882752702E06928657
chr88270876682709232E070-14759
chr88270927582709325E070-14666
chr88270935482709440E070-14551
chr88273635982736422E07012368
chr88273760682737656E07013615
chr88273770482737783E07013713
chr88274913582749745E07025144
chr88272692182727044E0712930
chr88272739782727713E0713406
chr88275040382750493E07126412
chr88275055782750622E07126566
chr88275073382750913E07126742
chr88275176982751905E07127778
chr88275192082751978E07127929
chr88275205182752101E07128060
chr88275213682752286E07128145
chr88275242482752500E07128433
chr88275252382752586E07128532
chr88275264882752702E07128657
chr88277068982771569E07146698
chr88269268482693377E072-30614
chr88272629482726439E0722303
chr88272692182727044E0722930
chr88272708482727145E0723093
chr88272739782727713E0723406
chr88272739782727713E0733406
chr88272692182727044E0742930
chr88275040382750493E07426412
chr88275055782750622E07426566
chr88275073382750913E07426742
chr88275118682751259E07427195
chr88275141582751459E07427424
chr88275155182751632E07427560
chr88275169382751743E07427702
chr88275176982751905E07427778
chr88275192082751978E07427929
chr88275205182752101E07428060
chr88275213682752286E07428145
chr88275242482752500E07428433
chr88275252382752586E07428532
chr88275264882752702E07428657
chr88269268482693377E081-30614
chr88274894182748991E08124950
chr88275118682751259E08127195
chr88275141582751459E08127424
chr88275155182751632E08127560
chr88275169382751743E08127702
chr88275176982751905E08127778
chr88275192082751978E08127929
chr88275205182752101E08128060
chr88275213682752286E08128145
chr88275242482752500E08128433
chr88275252382752586E08128532
chr88275264882752702E08128657
chr88269939382699447E082-24544
chr88269957982699654E082-24337
chr88274913582749745E08225144
chr88274982582749873E08225834
chr88275155182751632E08227560
chr88275169382751743E08227702
chr88275176982751905E08227778
chr88275192082751978E08227929
chr88275205182752101E08228060
chr88275213682752286E08228145
chr88275242482752500E08228433
chr88275252382752586E08228532










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr88275290282753069E06728911
chr88275314082753307E06729149
chr88275349982753591E06729508
chr88275360282754599E06729611
chr88275349982753591E06829508
chr88275360282754599E06829611
chr88275461982755486E06830628
chr88275290282753069E06928911
chr88275314082753307E06929149
chr88275349982753591E06929508
chr88275360282754599E06929611
chr88275290282753069E07028911
chr88275314082753307E07029149
chr88275349982753591E07029508
chr88275360282754599E07029611
chr88275290282753069E07128911
chr88275314082753307E07129149
chr88275349982753591E07129508
chr88275360282754599E07129611
chr88275461982755486E07130628
chr88275290282753069E07228911
chr88275314082753307E07229149
chr88275349982753591E07229508
chr88275360282754599E07229611
chr88275290282753069E07328911
chr88275314082753307E07329149
chr88275349982753591E07329508
chr88275360282754599E07329611
chr88275461982755486E07330628
chr88275314082753307E07429149
chr88275349982753591E07429508
chr88275360282754599E07429611
chr88275461982755486E07430628
chr88275360282754599E08129611
chr88275290282753069E08228911
chr88275314082753307E08229149
chr88275349982753591E08229508
chr88275360282754599E08229611
chr88275461982755486E08230628