rs7825359

Homo sapiens
A>G
DLGAP2 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0362 (10829/29906,GnomAD)
G=0371 (10815/29118,TOPMED)
G=0382 (1912/5008,1000G)
G=0253 (974/3854,ALSPAC)
G=0245 (907/3708,TWINSUK)
chr8:1699869 (GRCh38.p7) (8p23.3)
AD
GWASdb2
1   publication(s)
See rs on genome
66 Enhancers around
9 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.1699869A>G
GRCh37.p13 chr 8NC_000008.10:g.1648035A>G
DLGAP2 RefSeqGeneNG_009409.1:g.203467A>G
GRCh38.p7 chr 8 alt locus HSCHR8_5_CTG1NT_187654.1:g.309136A>G
GRCh38.p7 chr 8 alt locus HSCHR8_7_CTG1NT_187680.1:g.112531A>G

Gene: DLGAP2, discs large homolog associated protein 2(plus strand)

Molecule type Change Amino acid[Codon] SO Term
DLGAP2 transcript variant 2NM_001277161.1:c.N/AIntron Variant
DLGAP2 transcript variant 1NM_004745.4:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.470G=0.530
1000GenomesAmericanSub694A=0.650G=0.350
1000GenomesEast AsianSub1008A=0.644G=0.356
1000GenomesEuropeSub1006A=0.732G=0.268
1000GenomesGlobalStudy-wide5008A=0.618G=0.382
1000GenomesSouth AsianSub978A=0.650G=0.350
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.747G=0.253
The Genome Aggregation DatabaseAfricanSub8692A=0.512G=0.488
The Genome Aggregation DatabaseAmericanSub836A=0.600G=0.400
The Genome Aggregation DatabaseEast AsianSub1616A=0.657G=0.343
The Genome Aggregation DatabaseEuropeSub18460A=0.696G=0.303
The Genome Aggregation DatabaseGlobalStudy-wide29906A=0.637G=0.362
The Genome Aggregation DatabaseOtherSub302A=0.690G=0.310
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.628G=0.371
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.755G=0.245
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs78253590.000501alcohol dependence24277619

eQTL of rs7825359 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7825359 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr816207611621223E067-26812
chr816213281621464E067-26571
chr816833121683432E06735277
chr816834671684372E06735432
chr816846781684902E06736643
chr816931241695462E06745089
chr816438721644281E068-3754
chr816443571644416E068-3619
chr816931241695462E06845089
chr816931241695462E06945089
chr816487071648804E070672
chr816507081650818E0702673
chr816207611621223E071-26812
chr816213281621464E071-26571
chr816834671684372E07135432
chr816931241695462E07145089
chr816959131696039E07147878
chr816186231618681E072-29354
chr816186821618798E072-29237
chr816438721644281E072-3754
chr816443571644416E072-3619
chr816833121683432E07235277
chr816834671684372E07235432
chr816931241695462E07245089
chr816161611616211E073-31824
chr816207611621223E073-26812
chr816438721644281E073-3754
chr816834671684372E07335432
chr816931241695462E07345089
chr815994301599505E074-48530
chr815995821599622E074-48413
chr816487071648804E074672
chr816834671684372E07435432
chr816850231685065E07436988
chr816924621692602E07444427
chr816926911692834E07444656
chr816931241695462E07445089
chr816183291618487E081-29548
chr816184891618566E081-29469
chr816186231618681E081-29354
chr816186821618798E081-29237
chr816188371619017E081-29018
chr816193121619362E081-28673
chr816194591619513E081-28522
chr816264061626459E081-21576
chr816438721644281E081-3754
chr816443571644416E081-3619
chr816532211653312E0815186
chr816533611653449E0815326
chr816534581653596E0815423
chr816536011653655E0815566
chr816538601654061E0815825
chr816540621654229E0816027
chr816543661654417E0816331
chr816970631697169E08149028
chr816973891697486E08149354
chr816153541615418E082-32617
chr816507081650818E0822673
chr816532211653312E0825186
chr816533611653449E0825326
chr816534581653596E0825423
chr816536011653655E0825566
chr816538601654061E0825825
chr816540621654229E0826027
chr816543661654417E0826331
chr816544681654699E0826433










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr816488281650367E067793
chr816488281650367E068793
chr816488281650367E069793
chr816488281650367E070793
chr816488281650367E071793
chr816488281650367E072793
chr816488281650367E073793
chr816488281650367E074793
chr816488281650367E082793