rs7829966

Organism: Homo sapiens

Alleles: G>A

Gene : Feature

ST18 : Intron Variant

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

A=0406 (12166/29934,GnomAD)
A=0475 (13840/29118,TOPMED)
A=0462 (2316/5008,1000G)
A=0227 (875/3854,ALSPAC)
A=0226 (839/3708,TWINSUK)

Position: chr8:52169257 (GRCh38.p7) (8q11.23)

Phenotype: ND

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 208 Enhancers around

Promoter: 0 Promoter around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 8	NC_000008.11:g.52169257G>A
GRCh37.p13 chr 8	NC_000008.10:g.53081817G>A

Gene: ST18, suppression of tumorigenicity 18, zinc finger(minus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
ST18 transcript variant 1	NM_014682.2:c.	N/A	Intron Variant
ST18 transcript variant X9	XM_006716487.1:c.	N/A	Intron Variant
ST18 transcript variant X2	XM_011517629.1:c.	N/A	Intron Variant
ST18 transcript variant X12	XM_011517631.1:c.	N/A	Intron Variant
ST18 transcript variant X3	XM_011517632.1:c.	N/A	Intron Variant
ST18 transcript variant X4	XM_011517633.1:c.	N/A	Intron Variant
ST18 transcript variant X11	XM_011517634.1:c.	N/A	Intron Variant
ST18 transcript variant X2	XM_011517635.1:c.	N/A	Intron Variant
ST18 transcript variant X7	XM_011517636.2:c.	N/A	Intron Variant
ST18 transcript variant X5	XM_011517637.1:c.	N/A	Intron Variant
ST18 transcript variant X33	XM_011517638.2:c.	N/A	Intron Variant
ST18 transcript variant X6	XM_011517641.1:c.	N/A	Intron Variant
ST18 transcript variant X7	XM_011517642.1:c.	N/A	Intron Variant
ST18 transcript variant X1	XM_017014047.1:c.	N/A	Intron Variant
ST18 transcript variant X5	XM_017014048.1:c.	N/A	Intron Variant
ST18 transcript variant X6	XM_017014049.1:c.	N/A	Intron Variant
ST18 transcript variant X8	XM_017014050.1:c.	N/A	Intron Variant
ST18 transcript variant X10	XM_017014051.1:c.	N/A	Intron Variant
ST18 transcript variant X13	XM_017014052.1:c.	N/A	Intron Variant
ST18 transcript variant X14	XM_017014053.1:c.	N/A	Intron Variant
ST18 transcript variant X15	XM_017014054.1:c.	N/A	Intron Variant
ST18 transcript variant X16	XM_017014055.1:c.	N/A	Intron Variant
ST18 transcript variant X17	XM_017014056.1:c.	N/A	Intron Variant
ST18 transcript variant X18	XM_017014057.1:c.	N/A	Intron Variant
ST18 transcript variant X1	XM_017014058.1:c.	N/A	Intron Variant
ST18 transcript variant X20	XM_017014059.1:c.	N/A	Intron Variant
ST18 transcript variant X21	XM_017014060.1:c.	N/A	Intron Variant
ST18 transcript variant X22	XM_017014061.1:c.	N/A	Intron Variant
ST18 transcript variant X23	XM_017014062.1:c.	N/A	Intron Variant
ST18 transcript variant X24	XM_017014063.1:c.	N/A	Intron Variant
ST18 transcript variant X25	XM_017014064.1:c.	N/A	Intron Variant
ST18 transcript variant X27	XM_017014065.1:c.	N/A	Intron Variant
ST18 transcript variant X28	XM_017014066.1:c.	N/A	Intron Variant
ST18 transcript variant X29	XM_017014067.1:c.	N/A	Intron Variant
ST18 transcript variant X30	XM_017014068.1:c.	N/A	Intron Variant
ST18 transcript variant X32	XM_017014069.1:c.	N/A	Intron Variant
ST18 transcript variant X34	XM_017014070.1:c.	N/A	Intron Variant
ST18 transcript variant X35	XM_017014071.1:c.	N/A	Intron Variant
ST18 transcript variant X36	XM_017014072.1:c.	N/A	Intron Variant
ST18 transcript variant X37	XM_017014073.1:c.	N/A	Intron Variant
ST18 transcript variant X38	XM_017014074.1:c.	N/A	Intron Variant
ST18 transcript variant X40	XM_017014075.1:c.	N/A	Intron Variant
ST18 transcript variant X41	XM_017014076.1:c.	N/A	Intron Variant
ST18 transcript variant X42	XM_017014077.1:c.	N/A	Intron Variant
ST18 transcript variant X43	XM_017014078.1:c.	N/A	Intron Variant
ST18 transcript variant X44	XM_017014079.1:c.	N/A	Intron Variant
ST18 transcript variant X45	XM_017014080.1:c.	N/A	Intron Variant
ST18 transcript variant X47	XM_017014081.1:c.	N/A	Intron Variant
ST18 transcript variant X48	XM_017014082.1:c.	N/A	Intron Variant
ST18 transcript variant X49	XM_017014083.1:c.	N/A	Intron Variant
ST18 transcript variant X50	XM_017014084.1:c.	N/A	Intron Variant

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.109	A=0.891
1000Genomes	American	Sub	694	G=0.720	A=0.280
1000Genomes	East Asian	Sub	1008	G=0.659	A=0.341
1000Genomes	Europe	Sub	1006	G=0.769	A=0.231
1000Genomes	Global	Study-wide	5008	G=0.538	A=0.462
1000Genomes	South Asian	Sub	978	G=0.620	A=0.380
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.773	A=0.227
The Genome Aggregation Database	African	Sub	8702	G=0.190	A=0.810
The Genome Aggregation Database	American	Sub	836	G=0.700	A=0.300
The Genome Aggregation Database	East Asian	Sub	1614	G=0.687	A=0.313
The Genome Aggregation Database	Europe	Sub	18480	G=0.767	A=0.232
The Genome Aggregation Database	Global	Study-wide	29934	G=0.593	A=0.406
The Genome Aggregation Database	Other	Sub	302	G=0.800	A=0.200
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.524	A=0.475
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.774	A=0.226

PMID	Title	Author	Journal
17158188	Novel genes identified in a high-density genome wide association study for nicotine dependence.	Bierut LJ	Hum Mol Genet

P-Value

SNP ID	p-value	Traits	Study
rs7829966	0.000188	nicotine dependence	17158188

eQTL of rs7829966 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs7829966 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr8	53059302	53059786	E067	-22031
chr8	53059920	53060030	E067	-21787
chr8	53063086	53063276	E067	-18541
chr8	53063401	53063553	E067	-18264
chr8	53063592	53063812	E067	-18005
chr8	53063818	53064047	E067	-17770
chr8	53064111	53064283	E067	-17534
chr8	53064362	53064568	E067	-17249
chr8	53064640	53064832	E067	-16985
chr8	53064863	53064976	E067	-16841
chr8	53085983	53086111	E067	4166
chr8	53087780	53087831	E067	5963
chr8	53087922	53088001	E067	6105
chr8	53088158	53088198	E067	6341
chr8	53106798	53106904	E067	24981
chr8	53107057	53107107	E067	25240
chr8	53128339	53128424	E067	46522
chr8	53131347	53131405	E067	49530
chr8	53131422	53131472	E067	49605
chr8	53131580	53131630	E067	49763
chr8	53131707	53131791	E067	49890
chr8	53085983	53086111	E068	4166
chr8	53086224	53086718	E068	4407
chr8	53086891	53086945	E068	5074
chr8	53087026	53087268	E068	5209
chr8	53087308	53087466	E068	5491
chr8	53087780	53087831	E068	5963
chr8	53087922	53088001	E068	6105
chr8	53088158	53088198	E068	6341
chr8	53127660	53127722	E068	45843
chr8	53127872	53127922	E068	46055
chr8	53128339	53128424	E068	46522
chr8	53128759	53128956	E068	46942
chr8	53037398	53037448	E069	-44369
chr8	53037518	53037679	E069	-44138
chr8	53085983	53086111	E069	4166
chr8	53086224	53086718	E069	4407
chr8	53086891	53086945	E069	5074
chr8	53087026	53087268	E069	5209
chr8	53087308	53087466	E069	5491
chr8	53087780	53087831	E069	5963
chr8	53087922	53088001	E069	6105
chr8	53088158	53088198	E069	6341
chr8	53126929	53127171	E069	45112
chr8	53127660	53127722	E069	45843
chr8	53127872	53127922	E069	46055
chr8	53128339	53128424	E069	46522
chr8	53128759	53128956	E069	46942
chr8	53058260	53058310	E070	-23507
chr8	53058643	53058693	E070	-23124
chr8	53058723	53058792	E070	-23025
chr8	53058867	53059256	E070	-22561
chr8	53062899	53063077	E070	-18740
chr8	53063086	53063276	E070	-18541
chr8	53063401	53063553	E070	-18264
chr8	53063592	53063812	E070	-18005
chr8	53063818	53064047	E070	-17770
chr8	53064111	53064283	E070	-17534
chr8	53064362	53064568	E070	-17249
chr8	53064640	53064832	E070	-16985
chr8	53064863	53064976	E070	-16841
chr8	53080605	53080655	E070	-1162
chr8	53080923	53080984	E070	-833
chr8	53081096	53081179	E070	-638
chr8	53083190	53083240	E070	1373
chr8	53085666	53085727	E070	3849
chr8	53086224	53086718	E070	4407
chr8	53087922	53088001	E070	6105
chr8	53088158	53088198	E070	6341
chr8	53096656	53096753	E070	14839
chr8	53109067	53109117	E070	27250
chr8	53109455	53109505	E070	27638
chr8	53109675	53109725	E070	27858
chr8	53110332	53110386	E070	28515
chr8	53111422	53111524	E070	29605
chr8	53127660	53127722	E070	45843
chr8	53127872	53127922	E070	46055
chr8	53128339	53128424	E070	46522
chr8	53128759	53128956	E070	46942
chr8	53058643	53058693	E071	-23124
chr8	53058723	53058792	E071	-23025
chr8	53062198	53062279	E071	-19538
chr8	53062357	53062423	E071	-19394
chr8	53062523	53062633	E071	-19184
chr8	53062899	53063077	E071	-18740
chr8	53063086	53063276	E071	-18541
chr8	53063401	53063553	E071	-18264
chr8	53063592	53063812	E071	-18005
chr8	53063818	53064047	E071	-17770
chr8	53064111	53064283	E071	-17534
chr8	53064362	53064568	E071	-17249
chr8	53064640	53064832	E071	-16985
chr8	53064863	53064976	E071	-16841
chr8	53085983	53086111	E071	4166
chr8	53086224	53086718	E071	4407
chr8	53086891	53086945	E071	5074
chr8	53087026	53087268	E071	5209
chr8	53087308	53087466	E071	5491
chr8	53087780	53087831	E071	5963
chr8	53087922	53088001	E071	6105
chr8	53088158	53088198	E071	6341
chr8	53126929	53127171	E071	45112
chr8	53127660	53127722	E071	45843
chr8	53127872	53127922	E071	46055
chr8	53128339	53128424	E071	46522
chr8	53128759	53128956	E071	46942
chr8	53062523	53062633	E072	-19184
chr8	53062899	53063077	E072	-18740
chr8	53063086	53063276	E072	-18541
chr8	53063401	53063553	E072	-18264
chr8	53063592	53063812	E072	-18005
chr8	53063818	53064047	E072	-17770
chr8	53064111	53064283	E072	-17534
chr8	53064362	53064568	E072	-17249
chr8	53064640	53064832	E072	-16985
chr8	53064863	53064976	E072	-16841
chr8	53065794	53065854	E072	-15963
chr8	53065874	53065924	E072	-15893
chr8	53085983	53086111	E072	4166
chr8	53086224	53086718	E072	4407
chr8	53086891	53086945	E072	5074
chr8	53087026	53087268	E072	5209
chr8	53087308	53087466	E072	5491
chr8	53087780	53087831	E072	5963
chr8	53087922	53088001	E072	6105
chr8	53088158	53088198	E072	6341
chr8	53089089	53089139	E072	7272
chr8	53096656	53096753	E072	14839
chr8	53106798	53106904	E072	24981
chr8	53107057	53107107	E072	25240
chr8	53107310	53107383	E072	25493
chr8	53126929	53127171	E072	45112
chr8	53127660	53127722	E072	45843
chr8	53127872	53127922	E072	46055
chr8	53128339	53128424	E072	46522
chr8	53128759	53128956	E072	46942
chr8	53085983	53086111	E073	4166
chr8	53086224	53086718	E073	4407
chr8	53087780	53087831	E073	5963
chr8	53087922	53088001	E073	6105
chr8	53088158	53088198	E073	6341
chr8	53127872	53127922	E073	46055
chr8	53128339	53128424	E073	46522
chr8	53058643	53058693	E074	-23124
chr8	53058723	53058792	E074	-23025
chr8	53060255	53060430	E074	-21387
chr8	53060618	53060727	E074	-21090
chr8	53060820	53060874	E074	-20943
chr8	53060999	53061049	E074	-20768
chr8	53061121	53061193	E074	-20624
chr8	53061331	53061381	E074	-20436
chr8	53061578	53062032	E074	-19785
chr8	53062198	53062279	E074	-19538
chr8	53062357	53062423	E074	-19394
chr8	53063086	53063276	E074	-18541
chr8	53063401	53063553	E074	-18264
chr8	53063592	53063812	E074	-18005
chr8	53063818	53064047	E074	-17770
chr8	53064111	53064283	E074	-17534
chr8	53064362	53064568	E074	-17249
chr8	53064640	53064832	E074	-16985
chr8	53064863	53064976	E074	-16841
chr8	53085983	53086111	E074	4166
chr8	53086224	53086718	E074	4407
chr8	53086891	53086945	E074	5074
chr8	53087026	53087268	E074	5209
chr8	53087308	53087466	E074	5491
chr8	53087780	53087831	E074	5963
chr8	53087922	53088001	E074	6105
chr8	53088158	53088198	E074	6341
chr8	53126929	53127171	E074	45112
chr8	53127660	53127722	E074	45843
chr8	53127872	53127922	E074	46055
chr8	53128339	53128424	E074	46522
chr8	53128759	53128956	E074	46942
chr8	53131347	53131405	E074	49530
chr8	53131422	53131472	E074	49605
chr8	53131580	53131630	E074	49763
chr8	53131707	53131791	E074	49890
chr8	53062899	53063077	E081	-18740
chr8	53063086	53063276	E081	-18541
chr8	53063401	53063553	E081	-18264
chr8	53063592	53063812	E081	-18005
chr8	53063818	53064047	E081	-17770
chr8	53064111	53064283	E081	-17534
chr8	53064362	53064568	E081	-17249
chr8	53064640	53064832	E081	-16985
chr8	53064863	53064976	E081	-16841
chr8	53066670	53066720	E081	-15097
chr8	53066770	53067130	E081	-14687
chr8	53069266	53069316	E081	-12501
chr8	53087780	53087831	E081	5963
chr8	53087922	53088001	E081	6105
chr8	53088158	53088198	E081	6341
chr8	53128339	53128424	E081	46522
chr8	53128759	53128956	E081	46942
chr8	53062523	53062633	E082	-19184
chr8	53063592	53063812	E082	-18005
chr8	53063818	53064047	E082	-17770
chr8	53064111	53064283	E082	-17534
chr8	53064362	53064568	E082	-17249
chr8	53064640	53064832	E082	-16985
chr8	53085983	53086111	E082	4166
chr8	53086224	53086718	E082	4407
chr8	53086891	53086945	E082	5074
chr8	53087026	53087268	E082	5209
chr8	53128339	53128424	E082	46522
chr8	53128759	53128956	E082	46942