rs7835993

Organism: Homo sapiens

Alleles: G>A

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

A=0482 (14430/29906,GnomAD)
G==0499 (14536/29118,TOPMED)
G==0416 (2081/5008,1000G)
A=0324 (1250/3854,ALSPAC)
A=0324 (1200/3708,TWINSUK)

Position: chr8:59308573 (GRCh38.p7) (8q12.1)

Phenotype: AD

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 49 Enhancers around

Promoter: 0 Promoter around

Sequence Name	Change(s)
GRCh38.p7 chr 8	NC_000008.11:g.59308573G>A
GRCh37.p13 chr 8	NC_000008.10:g.60221132G>A

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.259	A=0.741
1000Genomes	American	Sub	694	G=0.400	A=0.600
1000Genomes	East Asian	Sub	1008	G=0.222	A=0.778
1000Genomes	Europe	Sub	1006	G=0.666	A=0.334
1000Genomes	Global	Study-wide	5008	G=0.416	A=0.584
1000Genomes	South Asian	Sub	978	G=0.580	A=0.420
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.676	A=0.324
The Genome Aggregation Database	African	Sub	8714	G=0.311	A=0.689
The Genome Aggregation Database	American	Sub	832	G=0.420	A=0.580
The Genome Aggregation Database	East Asian	Sub	1600	G=0.221	A=0.779
The Genome Aggregation Database	Europe	Sub	18458	G=0.642	A=0.357
The Genome Aggregation Database	Global	Study-wide	29906	G=0.517	A=0.482
The Genome Aggregation Database	Other	Sub	302	G=0.680	A=0.320
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.499	A=0.500
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.676	A=0.324

PMID	Title	Author	Journal
20201924	Genome-wide association study of alcohol dependence implicates a region on chromosome 11.	Edenberg HJ	Alcohol Clin Exp Res

SNP ID	p-value	Traits	Study
rs7835993	0.000797	alcohol dependence	20201924

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

There is no significant Hi-C chromatin interaction data for this SNP.

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr8	60218455	60218555	E070	-2577
chr8	60218601	60218688	E070	-2444
chr8	60222554	60222634	E070	1422
chr8	60222668	60222711	E070	1536
chr8	60177528	60177642	E081	-43490
chr8	60194719	60194848	E081	-26284
chr8	60196902	60197019	E081	-24113
chr8	60197129	60197231	E081	-23901
chr8	60197500	60197883	E081	-23249
chr8	60202162	60202586	E081	-18546
chr8	60202640	60202734	E081	-18398
chr8	60202933	60202983	E081	-18149
chr8	60203251	60203301	E081	-17831
chr8	60203963	60204309	E081	-16823
chr8	60213222	60213821	E081	-7311
chr8	60213844	60214066	E081	-7066
chr8	60217421	60217543	E081	-3589
chr8	60217663	60217964	E081	-3168
chr8	60217971	60218418	E081	-2714
chr8	60218455	60218555	E081	-2577
chr8	60218601	60218688	E081	-2444
chr8	60218976	60220190	E081	-942
chr8	60220229	60220412	E081	-720
chr8	60220727	60220781	E081	-351
chr8	60221203	60222071	E081	71
chr8	60222094	60222144	E081	962
chr8	60222463	60222529	E081	1331
chr8	60222554	60222634	E081	1422
chr8	60222668	60222711	E081	1536
chr8	60223095	60223296	E081	1963
chr8	60223775	60223815	E081	2643
chr8	60224092	60224142	E081	2960
chr8	60224716	60224897	E081	3584
chr8	60194719	60194848	E082	-26284
chr8	60196902	60197019	E082	-24113
chr8	60197129	60197231	E082	-23901
chr8	60202640	60202734	E082	-18398
chr8	60202933	60202983	E082	-18149
chr8	60203251	60203301	E082	-17831
chr8	60217971	60218418	E082	-2714
chr8	60218455	60218555	E082	-2577
chr8	60218601	60218688	E082	-2444
chr8	60220727	60220781	E082	-351
chr8	60221203	60222071	E082	71
chr8	60222094	60222144	E082	962
chr8	60222463	60222529	E082	1331
chr8	60222554	60222634	E082	1422
chr8	60222668	60222711	E082	1536
chr8	60223095	60223296	E082	1963