rs7844115

Homo sapiens
C>G
MSRA : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0350 (10499/29920,GnomAD)
G=0409 (11927/29118,TOPMED)
G=0390 (1952/5008,1000G)
G=0251 (967/3854,ALSPAC)
G=0258 (956/3708,TWINSUK)
chr8:10206985 (GRCh38.p7) (8p23.1)
ND
GWASdb2
1   publication(s)
See rs on genome
258 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.10206985C>G
GRCh37.p13 chr 8NC_000008.10:g.10064495C>G

Gene: MSRA, methionine sulfoxide reductase A(plus strand)

Molecule type Change Amino acid[Codon] SO Term
MSRA transcript variant 2NM_001135670.2:c.N/AIntron Variant
MSRA transcript variant 3NM_001135671.2:c.N/AIntron Variant
MSRA transcript variant 4NM_001199729.2:c.N/AIntron Variant
MSRA transcript variant 1NM_012331.4:c.N/AIntron Variant
MSRA transcript variant X1XM_011543822.1:c.N/AIntron Variant
MSRA transcript variant X2XM_011543823.2:c.N/AIntron Variant
MSRA transcript variant X3XM_017013448.1:c.N/AIntron Variant
MSRA transcript variant X4XM_017013449.1:c.N/AIntron Variant
MSRA transcript variant X5XM_017013450.1:c.N/AIntron Variant
MSRA transcript variant X6XM_017013451.1:c.N/AIntron Variant
MSRA transcript variant X7XM_017013452.1:c.N/AIntron Variant
MSRA transcript variant X8XM_017013453.1:c.N/AIntron Variant
MSRA transcript variant X9XM_017013454.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.296G=0.704
1000GenomesAmericanSub694C=0.770G=0.230
1000GenomesEast AsianSub1008C=0.727G=0.273
1000GenomesEuropeSub1006C=0.801G=0.199
1000GenomesGlobalStudy-wide5008C=0.610G=0.390
1000GenomesSouth AsianSub978C=0.610G=0.390
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.749G=0.251
The Genome Aggregation DatabaseAfricanSub8702C=0.375G=0.625
The Genome Aggregation DatabaseAmericanSub838C=0.740G=0.260
The Genome Aggregation DatabaseEast AsianSub1616C=0.726G=0.274
The Genome Aggregation DatabaseEuropeSub18462C=0.765G=0.234
The Genome Aggregation DatabaseGlobalStudy-wide29920C=0.649G=0.350
The Genome Aggregation DatabaseOtherSub302C=0.770G=0.230
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.590G=0.409
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.742G=0.258
PMID Title Author Journal
19268276Genome-wide association study of smoking initiation and current smoking.Vink JMAm J Hum Genet

P-Value

SNP ID p-value Traits Study
rs78441154.9E-05nicotine smoking19268276

eQTL of rs7844115 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7844115 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr81002410010024185E067-40310
chr81002450410024554E067-39941
chr81002465810024844E067-39651
chr81002495410025184E067-39311
chr81003069210031466E067-33029
chr81003680810037556E067-26939
chr81005359310053827E067-10668
chr81005397310054023E067-10472
chr81002465810024844E068-39651
chr81003069210031466E068-33029
chr81002410010024185E069-40310
chr81002450410024554E069-39941
chr81002465810024844E069-39651
chr81002495410025184E069-39311
chr81002525110025323E069-39172
chr81003069210031466E069-33029
chr81005608610056146E069-8349
chr81005616110056329E069-8166
chr81001867110018711E070-45784
chr81001893110018981E070-45514
chr81002146110021501E070-42994
chr81002179310021957E070-42538
chr81002410010024185E070-40310
chr81002450410024554E070-39941
chr81002465810024844E070-39651
chr81002495410025184E070-39311
chr81002525110025323E070-39172
chr81002555910025599E070-38896
chr81002583910025905E070-38590
chr81003009510030178E070-34317
chr81003020910030266E070-34229
chr81003037710030524E070-33971
chr81003055210030669E070-33826
chr81003069210031466E070-33029
chr81004374210043874E070-20621
chr81004392310044013E070-20482
chr81004425510044701E070-19794
chr81005341410053569E070-10926
chr81006486910065723E070374
chr81007186110072265E0707366
chr81007824910078788E07013754
chr81010508710105293E07040592
chr81010565010105721E07041155
chr81010582610106095E07041331
chr81010647010106524E07041975
chr81010719610107253E07042701
chr81010730810107541E07042813
chr81010759410108199E07043099
chr81010826210108312E07043767
chr81011116110111201E07046666
chr81011132710111446E07046832
chr81011144710111696E07046952
chr81011173710111777E07047242
chr81011295310113114E07048458
chr81011346610113516E07048971
chr81002450410024554E071-39941
chr81002465810024844E071-39651
chr81002495410025184E071-39311
chr81002525110025323E071-39172
chr81003069210031466E071-33029
chr81007824910078788E07113754
chr81011183910111879E07147344
chr81002410010024185E072-40310
chr81002450410024554E072-39941
chr81002465810024844E072-39651
chr81002495410025184E072-39311
chr81003069210031466E072-33029
chr81003183810031929E072-32566
chr81003201910032069E072-32426
chr81003214910032257E072-32238
chr81005616110056329E072-8166
chr81006470910064825E072214
chr81010461210104666E07240117
chr81002352010023570E073-40925
chr81002410010024185E073-40310
chr81002450410024554E073-39941
chr81002465810024844E073-39651
chr81002495410025184E073-39311
chr81003009510030178E073-34317
chr81003069210031466E073-33029
chr81003183810031929E073-32566
chr81003619010036244E073-28251
chr81003662710036677E073-27818
chr81003680810037556E073-26939
chr81005486210055071E073-9424
chr81005511510055494E073-9001
chr81002450410024554E074-39941
chr81002465810024844E074-39651
chr81002495410025184E074-39311
chr81002525110025323E074-39172
chr81003020910030266E074-34229
chr81003037710030524E074-33971
chr81003425210034315E074-30180
chr81005486210055071E074-9424
chr81005511510055494E074-9001
chr81005591210055962E074-8533
chr81005608610056146E074-8349
chr81005616110056329E074-8166
chr81005710510057178E074-7317
chr81011210810112158E07447613
chr81001667210016722E081-47773
chr81001709110017331E081-47164
chr81002096610021049E081-43446
chr81002146110021501E081-42994
chr81002179310021957E081-42538
chr81002267710022727E081-41768
chr81002352010023570E081-40925
chr81002410010024185E081-40310
chr81002450410024554E081-39941
chr81002465810024844E081-39651
chr81002495410025184E081-39311
chr81002525110025323E081-39172
chr81002555910025599E081-38896
chr81002639210026649E081-37846
chr81002829410028358E081-36137
chr81002854310028621E081-35874
chr81002866210028874E081-35621
chr81002907810029345E081-35150
chr81002989410029944E081-34551
chr81003009510030178E081-34317
chr81003020910030266E081-34229
chr81003037710030524E081-33971
chr81003055210030669E081-33826
chr81003069210031466E081-33029
chr81003183810031929E081-32566
chr81003201910032069E081-32426
chr81003214910032257E081-32238
chr81003236410032453E081-32042
chr81003245810032560E081-31935
chr81003265110032704E081-31791
chr81003271210033025E081-31470
chr81003316110033222E081-31273
chr81003339410034103E081-30392
chr81003425210034315E081-30180
chr81003549610035557E081-28938
chr81003566510035880E081-28615
chr81003619010036244E081-28251
chr81003662710036677E081-27818
chr81003680810037556E081-26939
chr81003762710037706E081-26789
chr81003778610037872E081-26623
chr81003798510038159E081-26336
chr81003870310038769E081-25726
chr81003885810038908E081-25587
chr81003949410039554E081-24941
chr81004374210043874E081-20621
chr81004392310044013E081-20482
chr81004425510044701E081-19794
chr81004471410044768E081-19727
chr81004489810045061E081-19434
chr81004541610045456E081-19039
chr81004560210045656E081-18839
chr81004567310045782E081-18713
chr81004944210049513E081-14982
chr81004964810049708E081-14787
chr81004982010050483E081-14012
chr81005095410051374E081-13121
chr81005206110052305E081-12190
chr81005234210052403E081-12092
chr81005341410053569E081-10926
chr81005359310053827E081-10668
chr81005397310054023E081-10472
chr81005410010054160E081-10335
chr81005443310054487E081-10008
chr81005452410054591E081-9904
chr81005471410054764E081-9731
chr81005486210055071E081-9424
chr81005511510055494E081-9001
chr81005591210055962E081-8533
chr81005608610056146E081-8349
chr81005616110056329E081-8166
chr81005710510057178E081-7317
chr81005756910057728E081-6767
chr81005804710058282E081-6213
chr81005838710058513E081-5982
chr81006238110062431E081-2064
chr81006334810063414E081-1081
chr81006361110063747E081-748
chr81006388710063953E081-542
chr81006406310064117E081-378
chr81006470910064825E081214
chr81006486910065723E081374
chr81006592810066013E0811433
chr81006603210066082E0811537
chr81006647110066567E0811976
chr81006668310066748E0812188
chr81006715310067240E0812658
chr81006731510067365E0812820
chr81006737310067427E0812878
chr81006794410067998E0813449
chr81006903510069131E0814540
chr81007122310071308E0816728
chr81007135610071406E0816861
chr81007186110072265E0817366
chr81007286310072961E0818368
chr81007605510076601E08111560
chr81007677210076934E08112277
chr81007750010077562E08113005
chr81007767610077757E08113181
chr81007780010077854E08113305
chr81007789910078039E08113404
chr81007824910078788E08113754
chr81007905910079210E08114564
chr81010508710105293E08140592
chr81010565010105721E08141155
chr81010582610106095E08141331
chr81010719610107253E08142701
chr81010730810107541E08142813
chr81010759410108199E08143099
chr81010826210108312E08143767
chr81011295310113114E08148458
chr81011346610113516E08148971
chr81002146110021501E082-42994
chr81002179310021957E082-42538
chr81002410010024185E082-40310
chr81002450410024554E082-39941
chr81002465810024844E082-39651
chr81002495410025184E082-39311
chr81002525110025323E082-39172
chr81002555910025599E082-38896
chr81002989410029944E082-34551
chr81003009510030178E082-34317
chr81003020910030266E082-34229
chr81003037710030524E082-33971
chr81003055210030669E082-33826
chr81003069210031466E082-33029
chr81003183810031929E082-32566
chr81003201910032069E082-32426
chr81003214910032257E082-32238
chr81003236410032453E082-32042
chr81003245810032560E082-31935
chr81003265110032704E082-31791
chr81003271210033025E082-31470
chr81003316110033222E082-31273
chr81003339410034103E082-30392
chr81003425210034315E082-30180
chr81003680810037556E082-26939
chr81004982010050483E082-14012
chr81005206110052305E082-12190
chr81005234210052403E082-12092
chr81005341410053569E082-10926
chr81005359310053827E082-10668
chr81005471410054764E082-9731
chr81005486210055071E082-9424
chr81006388710063953E082-542
chr81006406310064117E082-378
chr81006470910064825E082214
chr81006486910065723E082374
chr81007186110072265E0827366
chr81007605510076601E08211560
chr81007677210076934E08212277
chr81010461210104666E08240117
chr81010470410104802E08240209
chr81010483310104898E08240338
chr81010508710105293E08240592
chr81010565010105721E08241155
chr81010582610106095E08241331
chr81011266610112796E08248171