rs7845564

Homo sapiens
C>T
RALYL : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0240 (7198/29940,GnomAD)
T=0238 (6948/29118,TOPMED)
T=0183 (914/5008,1000G)
T=0256 (987/3854,ALSPAC)
T=0270 (1000/3708,TWINSUK)
chr8:84206384 (GRCh38.p7) (8q21.2)
AD
GWASdb2
1   publication(s)
See rs on genome
23 Enhancers around
63 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.84206384C>T
GRCh37.p13 chr 8NC_000008.10:g.85118619C>T

Gene: RALYL, RALY RNA binding protein-like(plus strand)

Molecule type Change Amino acid[Codon] SO Term
RALYL transcript variant 1NM_001100391.1:c.N/AIntron Variant
RALYL transcript variant 2NM_001100392.1:c.N/AIntron Variant
RALYL transcript variant 4NM_001100393.1:c.N/AIntron Variant
RALYL transcript variant 5NM_001287243.1:c.N/AIntron Variant
RALYL transcript variant 3NM_173848.5:c.N/AIntron Variant
RALYL transcript variant 6NM_001287244.1:c.N/AGenic Upstream Transcript Variant
RALYL transcript variant X23XM_011517462.2:c.N/AIntron Variant
RALYL transcript variant X1XM_017013058.1:c.N/AIntron Variant
RALYL transcript variant X2XM_017013059.1:c.N/AIntron Variant
RALYL transcript variant X5XM_017013062.1:c.N/AIntron Variant
RALYL transcript variant X6XM_017013063.1:c.N/AIntron Variant
RALYL transcript variant X8XM_017013065.1:c.N/AIntron Variant
RALYL transcript variant X9XM_017013066.1:c.N/AIntron Variant
RALYL transcript variant X10XM_017013067.1:c.N/AIntron Variant
RALYL transcript variant X1XM_017013068.1:c.N/AIntron Variant
RALYL transcript variant X12XM_017013069.1:c.N/AIntron Variant
RALYL transcript variant X13XM_017013070.1:c.N/AIntron Variant
RALYL transcript variant X2XM_017013071.1:c.N/AIntron Variant
RALYL transcript variant X15XM_017013072.1:c.N/AIntron Variant
RALYL transcript variant X16XM_017013073.1:c.N/AIntron Variant
RALYL transcript variant X17XM_017013074.1:c.N/AIntron Variant
RALYL transcript variant X18XM_017013075.1:c.N/AIntron Variant
RALYL transcript variant X19XM_017013076.1:c.N/AIntron Variant
RALYL transcript variant X20XM_017013077.1:c.N/AIntron Variant
RALYL transcript variant X21XM_017013078.1:c.N/AIntron Variant
RALYL transcript variant X22XM_017013079.1:c.N/AIntron Variant
RALYL transcript variant X24XM_017013080.1:c.N/AIntron Variant
RALYL transcript variant X25XM_017013081.1:c.N/AIntron Variant
RALYL transcript variant X10XM_017013082.1:c.N/AIntron Variant
RALYL transcript variant X27XM_017013083.1:c.N/AIntron Variant
RALYL transcript variant X29XM_017013085.1:c.N/AIntron Variant
RALYL transcript variant X3XM_017013060.1:c.N/AGenic Upstream Transcript Variant
RALYL transcript variant X4XM_017013061.1:c.N/AGenic Upstream Transcript Variant
RALYL transcript variant X7XM_017013064.1:c.N/AGenic Upstream Transcript Variant
RALYL transcript variant X28XM_017013084.1:c.N/AGenic Upstream Transcript Variant
RALYL transcript variant X30XM_017013086.1:c.N/AGenic Upstream Transcript Variant
RALYL transcript variant X31XM_017013087.1:c.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.786T=0.214
1000GenomesAmericanSub694C=0.850T=0.150
1000GenomesEast AsianSub1008C=0.888T=0.112
1000GenomesEuropeSub1006C=0.760T=0.240
1000GenomesGlobalStudy-wide5008C=0.817T=0.183
1000GenomesSouth AsianSub978C=0.820T=0.180
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.744T=0.256
The Genome Aggregation DatabaseAfricanSub8718C=0.771T=0.229
The Genome Aggregation DatabaseAmericanSub838C=0.860T=0.140
The Genome Aggregation DatabaseEast AsianSub1616C=0.890T=0.110
The Genome Aggregation DatabaseEuropeSub18466C=0.737T=0.262
The Genome Aggregation DatabaseGlobalStudy-wide29940C=0.759T=0.240
The Genome Aggregation DatabaseOtherSub302C=0.800T=0.200
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.761T=0.238
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.730T=0.270
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs78455640.000816alcohol dependence21314694

eQTL of rs7845564 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7845564 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr88515829185158352E07039672
chr88515959785159749E07040978
chr88515994085160157E07041321
chr88516045885160508E07041839
chr88513327485133421E08114655
chr88513349685133756E08114877
chr88515829185158352E08139672
chr88515851585158565E08139896
chr88515935485159472E08140735
chr88515959785159749E08140978
chr88515994085160157E08141321
chr88516045885160508E08141839
chr88511661185116821E082-1798
chr88511686685116975E082-1644
chr88511736485117682E082-937
chr88515829185158352E08239672
chr88515851585158565E08239896
chr88515883085158880E08240211
chr88515893385158983E08240314
chr88515935485159472E08240735
chr88515959785159749E08240978
chr88515994085160157E08241321
chr88516045885160508E08241839



Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr88509432385096248E067-22371
chr88509625585096425E067-22194
chr88509648485097610E067-21009
chr88509761985097793E067-20826
chr88509787085097920E067-20699
chr88509798385098207E067-20412
chr88509836885098493E067-20126
chr88509854185098591E067-20028
chr88509379585094310E068-24309
chr88509432385096248E068-22371
chr88509625585096425E068-22194
chr88509648485097610E068-21009
chr88509761985097793E068-20826
chr88509787085097920E068-20699
chr88509798385098207E068-20412
chr88509836885098493E068-20126
chr88509854185098591E068-20028
chr88509432385096248E069-22371
chr88509625585096425E069-22194
chr88509648485097610E069-21009
chr88509761985097793E069-20826
chr88509787085097920E069-20699
chr88509432385096248E071-22371
chr88509625585096425E071-22194
chr88509648485097610E071-21009
chr88509379585094310E072-24309
chr88509625585096425E072-22194
chr88509648485097610E072-21009
chr88509761985097793E072-20826
chr88509787085097920E072-20699
chr88509432385096248E073-22371
chr88509625585096425E073-22194
chr88509648485097610E073-21009
chr88509761985097793E073-20826
chr88509787085097920E073-20699
chr88509798385098207E073-20412
chr88509836885098493E073-20126
chr88509854185098591E073-20028
chr88509873485098917E073-19702
chr88509432385096248E074-22371
chr88509625585096425E074-22194
chr88509648485097610E074-21009
chr88509379585094310E081-24309
chr88509432385096248E081-22371
chr88509625585096425E081-22194
chr88509648485097610E081-21009
chr88509761985097793E081-20826
chr88509787085097920E081-20699
chr88509798385098207E081-20412
chr88509836885098493E081-20126
chr88509854185098591E081-20028
chr88509873485098917E081-19702
chr88509379585094310E082-24309
chr88509432385096248E082-22371
chr88509625585096425E082-22194
chr88509648485097610E082-21009
chr88509761985097793E082-20826
chr88509787085097920E082-20699
chr88509798385098207E082-20412
chr88509836885098493E082-20126
chr88509854185098591E082-20028
chr88509873485098917E082-19702
chr88509910485099219E082-19400