rs7846006

Homo sapiens
A>G
GDAP1 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0472 (14121/29918,GnomAD)
G=0473 (13796/29118,TOPMED)
G=0451 (2260/5008,1000G)
G=0491 (1892/3854,ALSPAC)
G=0473 (1755/3708,TWINSUK)
chr8:74359739 (GRCh38.p7) (8q21.11)
ND
GWASdb2
1   publication(s)
See rs on genome
19 Enhancers around
52 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.74359739A>G
GRCh37.p13 chr 8NC_000008.10:g.75271974A>G
GDAP1 RefSeqGene LRG_244

Gene: GDAP1, ganglioside induced differentiation associated protein 1(plus strand)

Molecule type Change Amino acid[Codon] SO Term
GDAP1 transcript variant 2NM_001040875.2:c.N/AIntron Variant
GDAP1 transcript variant 1NM_018972.2:c.N/AIntron Variant
GDAP1 transcript variant 3NR_046346.1:n.N/AIntron Variant
GDAP1 transcript variant X1XM_011517551.2:c.N/AIntron Variant
GDAP1 transcript variant X4XM_011517552.2:c.N/AIntron Variant
GDAP1 transcript variant X2XM_017013585.1:c.N/AIntron Variant
GDAP1 transcript variant X3XM_017013586.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.551G=0.449
1000GenomesAmericanSub694A=0.620G=0.380
1000GenomesEast AsianSub1008A=0.579G=0.421
1000GenomesEuropeSub1006A=0.547G=0.453
1000GenomesGlobalStudy-wide5008A=0.549G=0.451
1000GenomesSouth AsianSub978A=0.460G=0.540
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.509G=0.491
The Genome Aggregation DatabaseAfricanSub8694A=0.548G=0.452
The Genome Aggregation DatabaseAmericanSub836A=0.610G=0.390
The Genome Aggregation DatabaseEast AsianSub1616A=0.606G=0.394
The Genome Aggregation DatabaseEuropeSub18472A=0.508G=0.491
The Genome Aggregation DatabaseGlobalStudy-wide29918A=0.528G=0.472
The Genome Aggregation DatabaseOtherSub300A=0.500G=0.500
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.526G=0.473
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.527G=0.473
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs78460060.000683nicotine dependence17158188

eQTL of rs7846006 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr8:75271974CTD-2320G14.2ENSG00000253596.1A>G1.1349e-29689Cortex

meQTL of rs7846006 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr87526429975264349E067-7625
chr87526452075264604E067-7370
chr87526429975264349E068-7625
chr87526452075264604E068-7370
chr87526429975264349E069-7625
chr87523982275239939E070-32035
chr87524030975240904E070-31070
chr87526429975264349E072-7625
chr87526452075264604E072-7370
chr87526429975264349E073-7625
chr87526452075264604E073-7370
chr87522955575229723E081-42251
chr87526118975261249E081-10725
chr87526429975264349E081-7625
chr87526452075264604E081-7370
chr87526118975261249E082-10725
chr87526577775265834E082-6140
chr87526591475265985E082-5989
chr87527160575271645E082-329








Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr87523156575231747E067-40227
chr87523183875232048E067-39926
chr87523225875234867E067-37107
chr87526204275262107E067-9867
chr87526216475263270E067-8704
chr87523088475231011E068-40963
chr87523123775231515E068-40459
chr87523156575231747E068-40227
chr87523183875232048E068-39926
chr87523225875234867E068-37107
chr87526155475261648E068-10326
chr87526187675261926E068-10048
chr87526204275262107E068-9867
chr87526216475263270E068-8704
chr87523183875232048E069-39926
chr87523225875234867E069-37107
chr87526187675261926E069-10048
chr87526204275262107E069-9867
chr87526216475263270E069-8704
chr87523183875232048E070-39926
chr87523225875234867E070-37107
chr87526155475261648E070-10326
chr87526187675261926E070-10048
chr87526204275262107E070-9867
chr87526216475263270E070-8704
chr87526204275262107E071-9867
chr87526216475263270E071-8704
chr87523183875232048E072-39926
chr87523225875234867E072-37107
chr87526155475261648E072-10326
chr87526187675261926E072-10048
chr87526204275262107E072-9867
chr87526216475263270E072-8704
chr87523225875234867E073-37107
chr87526187675261926E073-10048
chr87526204275262107E073-9867
chr87526216475263270E073-8704
chr87523225875234867E074-37107
chr87526216475263270E074-8704
chr87523225875234867E081-37107
chr87526187675261926E081-10048
chr87526204275262107E081-9867
chr87526216475263270E081-8704
chr87523088475231011E082-40963
chr87523123775231515E082-40459
chr87523156575231747E082-40227
chr87523183875232048E082-39926
chr87523225875234867E082-37107
chr87526155475261648E082-10326
chr87526187675261926E082-10048
chr87526204275262107E082-9867
chr87526216475263270E082-8704