rs7846521

Homo sapiens
A>G
SNX16 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A==0331 (9892/29836,GnomAD)
A==0339 (9893/29118,TOPMED)
A==0381 (1910/5008,1000G)
A==0332 (1280/3854,ALSPAC)
A==0321 (1190/3708,TWINSUK)
chr8:81805872 (GRCh38.p7) (8q21.13)
AD
GWASdb2
1   publication(s)
See rs on genome
93 Enhancers around
39 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.81805872A>G
GRCh37.p13 chr 8NC_000008.10:g.82718107A>G

Gene: SNX16, sorting nexin 16(minus strand)

Molecule type Change Amino acid[Codon] SO Term
SNX16 transcript variant 1NM_022133.3:c.N/AIntron Variant
SNX16 transcript variant 2NM_152836.2:c.N/AIntron Variant
SNX16 transcript variant 3NM_152837.2:c.N/AIntron Variant
SNX16 transcript variant X1XM_005251282.4:c.N/AIntron Variant
SNX16 transcript variant X2XM_005251283.2:c.N/AIntron Variant
SNX16 transcript variant X3XM_011517574.2:c.N/AIntron Variant
SNX16 transcript variant X3XR_001745572.1:n.N/AIntron Variant
SNX16 transcript variant X5XR_001745573.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.321G=0.679
1000GenomesAmericanSub694A=0.390G=0.610
1000GenomesEast AsianSub1008A=0.597G=0.403
1000GenomesEuropeSub1006A=0.327G=0.673
1000GenomesGlobalStudy-wide5008A=0.381G=0.619
1000GenomesSouth AsianSub978A=0.290G=0.710
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.332G=0.668
The Genome Aggregation DatabaseAfricanSub8672A=0.327G=0.673
The Genome Aggregation DatabaseAmericanSub834A=0.320G=0.680
The Genome Aggregation DatabaseEast AsianSub1612A=0.631G=0.369
The Genome Aggregation DatabaseEuropeSub18416A=0.307G=0.692
The Genome Aggregation DatabaseGlobalStudy-wide29836A=0.331G=0.668
The Genome Aggregation DatabaseOtherSub302A=0.370G=0.630
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.339G=0.660
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.321G=0.679
PMID Title Author Journal
23743675A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.Kapoor MHum Genet

P-Value

SNP ID p-value Traits Study
rs78465213.38E-05alcohol consumption23743675

eQTL of rs7846521 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7846521 in Fetal Brain

Probe ID Position Gene beta p-value
cg17211192chr8:82754475SNX160.06479748977329936.7363e-27
cg27398817chr8:82754497SNX160.03840175693116452.7176e-15
cg23324259chr8:82754387SNX160.01771319224007824.3004e-14

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr88272692182727044E0678814
chr88272708482727145E0678977
chr88272739782727713E0679290
chr88275141582751459E06733308
chr88275155182751632E06733444
chr88275169382751743E06733586
chr88275176982751905E06733662
chr88275192082751978E06733813
chr88275205182752101E06733944
chr88275213682752286E06734029
chr88275242482752500E06734317
chr88275252382752586E06734416
chr88274913582749745E06831028
chr88275040382750493E06832296
chr88275055782750622E06832450
chr88275073382750913E06832626
chr88275118682751259E06833079
chr88275141582751459E06833308
chr88275155182751632E06833444
chr88275169382751743E06833586
chr88275242482752500E06834317
chr88275252382752586E06834416
chr88275264882752702E06834541
chr88275205182752101E06933944
chr88275213682752286E06934029
chr88275242482752500E06934317
chr88275252382752586E06934416
chr88275264882752702E06934541
chr88270876682709232E070-8875
chr88270927582709325E070-8782
chr88270935482709440E070-8667
chr88273635982736422E07018252
chr88273760682737656E07019499
chr88273770482737783E07019597
chr88274913582749745E07031028
chr88272692182727044E0718814
chr88272739782727713E0719290
chr88275040382750493E07132296
chr88275055782750622E07132450
chr88275073382750913E07132626
chr88275176982751905E07133662
chr88275192082751978E07133813
chr88275205182752101E07133944
chr88275213682752286E07134029
chr88275242482752500E07134317
chr88275252382752586E07134416
chr88275264882752702E07134541
chr88269268482693377E072-24730
chr88272629482726439E0728187
chr88272692182727044E0728814
chr88272708482727145E0728977
chr88272739782727713E0729290
chr88272739782727713E0739290
chr88272692182727044E0748814
chr88275040382750493E07432296
chr88275055782750622E07432450
chr88275073382750913E07432626
chr88275118682751259E07433079
chr88275141582751459E07433308
chr88275155182751632E07433444
chr88275169382751743E07433586
chr88275176982751905E07433662
chr88275192082751978E07433813
chr88275205182752101E07433944
chr88275213682752286E07434029
chr88275242482752500E07434317
chr88275252382752586E07434416
chr88275264882752702E07434541
chr88269268482693377E081-24730
chr88274894182748991E08130834
chr88275118682751259E08133079
chr88275141582751459E08133308
chr88275155182751632E08133444
chr88275169382751743E08133586
chr88275176982751905E08133662
chr88275192082751978E08133813
chr88275205182752101E08133944
chr88275213682752286E08134029
chr88275242482752500E08134317
chr88275252382752586E08134416
chr88275264882752702E08134541
chr88269939382699447E082-18660
chr88269957982699654E082-18453
chr88274913582749745E08231028
chr88274982582749873E08231718
chr88275155182751632E08233444
chr88275169382751743E08233586
chr88275176982751905E08233662
chr88275192082751978E08233813
chr88275205182752101E08233944
chr88275213682752286E08234029
chr88275242482752500E08234317
chr88275252382752586E08234416










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr88275290282753069E06734795
chr88275314082753307E06735033
chr88275349982753591E06735392
chr88275360282754599E06735495
chr88275349982753591E06835392
chr88275360282754599E06835495
chr88275461982755486E06836512
chr88275290282753069E06934795
chr88275314082753307E06935033
chr88275349982753591E06935392
chr88275360282754599E06935495
chr88275290282753069E07034795
chr88275314082753307E07035033
chr88275349982753591E07035392
chr88275360282754599E07035495
chr88275290282753069E07134795
chr88275314082753307E07135033
chr88275349982753591E07135392
chr88275360282754599E07135495
chr88275461982755486E07136512
chr88275290282753069E07234795
chr88275314082753307E07235033
chr88275349982753591E07235392
chr88275360282754599E07235495
chr88275290282753069E07334795
chr88275314082753307E07335033
chr88275349982753591E07335392
chr88275360282754599E07335495
chr88275461982755486E07336512
chr88275314082753307E07435033
chr88275349982753591E07435392
chr88275360282754599E07435495
chr88275461982755486E07436512
chr88275360282754599E08135495
chr88275290282753069E08234795
chr88275314082753307E08235033
chr88275349982753591E08235392
chr88275360282754599E08235495
chr88275461982755486E08236512