rs7846671

Homo sapiens
A>G
None
Check p-value
SNV (Single Nucleotide Variation)
A==0244 (7314/29876,GnomAD)
A==0253 (7374/29118,TOPMED)
A==0202 (1011/5008,1000G)
A==0266 (1027/3854,ALSPAC)
A==0256 (949/3708,TWINSUK)
chr8:143102549 (GRCh38.p7) (8q24.3)
AD
GWASdb2
1   publication(s)
See rs on genome
76 Enhancers around
2 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.143102549A>G
GRCh37.p13 chr 8NC_000008.10:g.144183966A>G
GRCh38.p7 chr 8 alt locus HSCHR8_4_CTG7NT_187573.1:g.98134A>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.328G=0.672
1000GenomesAmericanSub694A=0.140G=0.860
1000GenomesEast AsianSub1008A=0.091G=0.909
1000GenomesEuropeSub1006A=0.244G=0.756
1000GenomesGlobalStudy-wide5008A=0.202G=0.798
1000GenomesSouth AsianSub978A=0.150G=0.850
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.266G=0.734
The Genome Aggregation DatabaseAfricanSub8682A=0.315G=0.685
The Genome Aggregation DatabaseAmericanSub836A=0.130G=0.870
The Genome Aggregation DatabaseEast AsianSub1620A=0.067G=0.933
The Genome Aggregation DatabaseEuropeSub18436A=0.233G=0.766
The Genome Aggregation DatabaseGlobalStudy-wide29876A=0.244G=0.755
The Genome Aggregation DatabaseOtherSub302A=0.180G=0.820
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.253G=0.746
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.256G=0.744
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs78466710.000801alcohol dependence21314694

eQTL of rs7846671 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr8:144183966CDC42P3ENSG00000253971.1A>G5.7598e-3106699Cerebellum

meQTL of rs7846671 in Fetal Brain

Probe ID Position Gene beta p-value
cg17892588chr8:144162379-0.02590847945975232.0802e-10

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr8144186099144186209E0672133
chr8144221561144221619E06737595
chr8144221673144221723E06737707
chr8144221726144221812E06737760
chr8144221897144222227E06737931
chr8144212497144212862E06828531
chr8144221561144221619E06837595
chr8144221673144221723E06837707
chr8144221726144221812E06837760
chr8144221897144222227E06837931
chr8144222252144222445E06838286
chr8144221561144221619E06937595
chr8144221673144221723E06937707
chr8144221726144221812E06937760
chr8144221897144222227E06937931
chr8144222252144222445E06938286
chr8144227683144228014E06943717
chr8144228032144228101E06944066
chr8144228121144228319E06944155
chr8144228349144228436E06944383
chr8144212497144212862E07028531
chr8144221561144221619E07037595
chr8144221673144221723E07037707
chr8144221726144221812E07037760
chr8144228032144228101E07044066
chr8144228121144228319E07044155
chr8144228349144228436E07044383
chr8144206677144206870E07122711
chr8144207011144207061E07123045
chr8144207072144207245E07123106
chr8144212366144212453E07128400
chr8144212497144212862E07128531
chr8144221726144221812E07137760
chr8144228349144228436E07144383
chr8144228495144228658E07144529
chr8144206677144206870E07222711
chr8144207011144207061E07223045
chr8144207072144207245E07223106
chr8144212497144212862E07228531
chr8144221726144221812E07237760
chr8144221897144222227E07237931
chr8144222252144222445E07238286
chr8144227683144228014E07243717
chr8144228032144228101E07244066
chr8144228121144228319E07244155
chr8144228349144228436E07244383
chr8144228495144228658E07244529
chr8144227683144228014E07343717
chr8144228032144228101E07344066
chr8144228121144228319E07344155
chr8144228349144228436E07344383
chr8144228495144228658E07344529
chr8144228777144228827E07344811
chr8144229255144229353E07345289
chr8144212366144212453E07428400
chr8144212497144212862E07428531
chr8144221561144221619E07437595
chr8144221673144221723E07437707
chr8144221726144221812E07437760
chr8144221897144222227E07437931
chr8144206677144206870E08122711
chr8144212497144212862E08128531
chr8144221897144222227E08137931
chr8144222252144222445E08138286
chr8144227683144228014E08143717
chr8144228032144228101E08144066
chr8144228121144228319E08144155
chr8144228349144228436E08144383
chr8144228495144228658E08144529
chr8144228777144228827E08144811
chr8144227683144228014E08243717
chr8144228032144228101E08244066
chr8144228121144228319E08244155
chr8144228349144228436E08244383
chr8144228495144228658E08244529
chr8144228777144228827E08244811










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr8144176472144177118E070-6848
chr8144176472144177118E082-6848