rs7846903

Homo sapiens
G>A
RORB : Intron Variant
RORB-AS1 : 2KB Upstream Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0288 (8636/29942,GnomAD)
A=0291 (8482/29118,TOPMED)
A=0233 (1165/5008,1000G)
A=0340 (1311/3854,ALSPAC)
A=0330 (1223/3708,TWINSUK)
chr9:74500195 (GRCh38.p7) (9q21.13)
ND
GWASdb2
1   publication(s)
See rs on genome

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 9NC_000009.12:g.74500195G>A
GRCh37.p13 chr 9NC_000009.11:g.77115111G>A
RORB RefSeqGeneNG_046926.1:g.7860G>A

Gene: RORB, RAR related orphan receptor B(plus strand)

Molecule type Change Amino acid[Codon] SO Term
RORB transcriptNM_006914.3:c.N/AIntron Variant

Gene: RORB-AS1, RORB antisense RNA 1(minus strand): 2KB Upstream Variant

Molecule type Change Amino acid[Codon] SO Term
RORB-AS1 transcriptNR_125791.1:n.N/AUpstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.764A=0.236
1000GenomesAmericanSub694G=0.560A=0.440
1000GenomesEast AsianSub1008G=0.938A=0.062
1000GenomesEuropeSub1006G=0.695A=0.305
1000GenomesGlobalStudy-wide5008G=0.767A=0.233
1000GenomesSouth AsianSub978G=0.820A=0.180
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.660A=0.340
The Genome Aggregation DatabaseAfricanSub8712G=0.760A=0.240
The Genome Aggregation DatabaseAmericanSub836G=0.550A=0.450
The Genome Aggregation DatabaseEast AsianSub1622G=0.917A=0.083
The Genome Aggregation DatabaseEuropeSub18470G=0.677A=0.322
The Genome Aggregation DatabaseGlobalStudy-wide29942G=0.711A=0.288
The Genome Aggregation DatabaseOtherSub302G=0.740A=0.260
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.708A=0.291
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.670A=0.330
PMID Title Author Journal
18227835Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking.Berrettini WMol Psychiatry

P-Value

SNP ID p-value Traits Study
rs78469030.000122nicotine dependence18227835

eQTL of rs7846903 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7846903 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr97713080177130881E06715690
chr97713098077131030E06715869
chr97714065877140724E06725547
chr97715783077157880E06742719
chr97715798777158133E06742876
chr97715819677158339E06743085
chr97715875477158804E06743643
chr97715889277158972E06743781
chr97715915277159378E06744041
chr97713609777136238E06820986
chr97715783077157880E06842719
chr97715798777158133E06842876
chr97715819677158339E06843085
chr97715875477158804E06843643
chr97715889277158972E06843781
chr97715915277159378E06844041
chr97715783077157880E06942719
chr97715798777158133E06942876
chr97715819677158339E06943085
chr97715875477158804E06943643
chr97715889277158972E06943781
chr97715915277159378E06944041
chr97711812677118237E0703015
chr97711840877118467E0703297
chr97711852077118570E0703409
chr97714960177149651E07034490
chr97714979877150040E07034687
chr97715783077157880E07142719
chr97715798777158133E07142876
chr97715819677158339E07143085
chr97715875477158804E07143643
chr97715889277158972E07143781
chr97715915277159378E07144041
chr97712146077121576E0726349
chr97712157977121629E0726468
chr97712204177122091E0726930
chr97714960177149651E07234490
chr97714979877150040E07234687
chr97715783077157880E07242719
chr97715798777158133E07242876
chr97715819677158339E07243085
chr97715875477158804E07243643
chr97715889277158972E07243781
chr97715915277159378E07244041
chr97715798777158133E07342876
chr97715819677158339E07343085
chr97715875477158804E07343643
chr97715889277158972E07343781
chr97715915277159378E07344041
chr97714145177141623E07426340
chr97714168977141750E07426578
chr97715798777158133E07442876
chr97715819677158339E07443085
chr97715875477158804E07443643
chr97715889277158972E07443781
chr97715915277159378E07444041
chr97714960177149651E08134490
chr97714979877150040E08134687
chr97715025977150309E08135148









Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr97711143977111623E067-3488
chr97711163477115990E0670
chr97711600877116173E067897
chr97711624077116294E0671129
chr97714077877140862E06725667
chr97714099977141069E06725888
chr97714117177141361E06726060
chr97711096177111020E068-4091
chr97711114577111195E068-3916
chr97711130877111393E068-3718
chr97711143977111623E068-3488
chr97711163477115990E0680
chr97711600877116173E068897
chr97714077877140862E06825667
chr97714099977141069E06825888
chr97714117177141361E06826060
chr97711096177111020E069-4091
chr97711114577111195E069-3916
chr97711130877111393E069-3718
chr97711143977111623E069-3488
chr97711163477115990E0690
chr97711600877116173E069897
chr97714077877140862E06925667
chr97714099977141069E06925888
chr97714117177141361E06926060
chr97711143977111623E070-3488
chr97711624077116294E0701129
chr97711096177111020E071-4091
chr97711114577111195E071-3916
chr97711130877111393E071-3718
chr97711143977111623E071-3488
chr97711163477115990E0710
chr97714077877140862E07125667
chr97714099977141069E07125888
chr97714117177141361E07126060
chr97711096177111020E072-4091
chr97711114577111195E072-3916
chr97711130877111393E072-3718
chr97711143977111623E072-3488
chr97711163477115990E0720
chr97711600877116173E072897
chr97711624077116294E0721129
chr97714077877140862E07225667
chr97714099977141069E07225888
chr97714117177141361E07226060
chr97711096177111020E073-4091
chr97711114577111195E073-3916
chr97711130877111393E073-3718
chr97711143977111623E073-3488
chr97711163477115990E0730
chr97711600877116173E073897
chr97711624077116294E0731129
chr97714077877140862E07325667
chr97714099977141069E07325888
chr97714117177141361E07326060
chr97711143977111623E074-3488
chr97711163477115990E0740
chr97714077877140862E07425667
chr97714099977141069E07425888
chr97714117177141361E07426060
chr97711163477115990E0810
chr97711143977111623E082-3488
chr97711163477115990E0820
chr97711624077116294E0821129