rs7857754

Homo sapiens
G>A / G>C
None
Check p-value
SNV (Single Nucleotide Variation)
G==0436 (13079/29956,GnomAD)
G==0481 (14017/29118,TOPMED)
G==0428 (2143/5008,1000G)
G==0398 (1532/3854,ALSPAC)
G==0399 (1479/3708,TWINSUK)
chr9:36738644 (GRCh38.p7) (9p13.2)
AD
GWASdb2
1   publication(s)
See rs on genome
135 Enhancers around
19 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 9NC_000009.12:g.36738644G>A
GRCh38.p7 chr 9NC_000009.12:g.36738644G>C
GRCh37.p13 chr 9NC_000009.11:g.36738641G>A
GRCh37.p13 chr 9NC_000009.11:g.36738641G>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.582A=0.418
1000GenomesAmericanSub694G=0.460A=0.540
1000GenomesEast AsianSub1008G=0.203A=0.797
1000GenomesEuropeSub1006G=0.379A=0.621
1000GenomesGlobalStudy-wide5008G=0.428A=0.572
1000GenomesSouth AsianSub978G=0.480A=0.520
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.398A=0.602
The Genome Aggregation DatabaseAfricanSub8716G=0.571C=0.000
The Genome Aggregation DatabaseAmericanSub838G=0.480C=0.00,
The Genome Aggregation DatabaseEast AsianSub1616G=0.196C=0.000
The Genome Aggregation DatabaseEuropeSub18484G=0.392C=0.000
The Genome Aggregation DatabaseGlobalStudy-wide29956G=0.436C=0.000
The Genome Aggregation DatabaseOtherSub302G=0.440C=0.00,
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.481A=0.518
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.399A=0.601
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs78577540.00056alcohol dependence20201924

eQTL of rs7857754 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7857754 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr971370437137108E067-45855
chr971371617137319E067-45644
chr971466027147434E067-35529
chr971474607147548E067-35415
chr971490397149114E067-33849
chr971697987169997E067-12966
chr971721697172497E067-10466
chr971725027172750E067-10213
chr971727667173088E067-9875
chr972098947209948E06726931
chr972102037210301E06727240
chr972103227210372E06727359
chr972108627211223E06727899
chr972112307211311E06728267
chr972113427211542E06728379
chr972128437213230E06729880
chr971450047145157E068-37806
chr971454037145463E068-37500
chr971455207146034E068-36929
chr971462307146397E068-36566
chr971464297146545E068-36418
chr971466027147434E068-35529
chr971474607147548E068-35415
chr971476397148552E068-34411
chr971531647154003E068-28960
chr971540117154190E068-28773
chr971718807172096E068-10867
chr971721697172497E068-10466
chr971725027172750E068-10213
chr971727667173088E068-9875
chr971730977173244E068-9719
chr971732877173408E068-9555
chr972102037210301E06827240
chr972103227210372E06827359
chr972108627211223E06827899
chr972112307211311E06828267
chr972113427211542E06828379
chr972128437213230E06829880
chr971466027147434E069-35529
chr971474607147548E069-35415
chr971476397148552E069-34411
chr971485847148655E069-34308
chr971494517149580E069-33383
chr971700787170331E069-12632
chr971721697172497E069-10466
chr971725027172750E069-10213
chr971727667173088E069-9875
chr971730977173244E069-9719
chr971732877173408E069-9555
chr972108627211223E06927899
chr972112307211311E06928267
chr972113427211542E06928379
chr972098947209948E07026931
chr972102037210301E07027240
chr972103227210372E07027359
chr972123457212512E07029382
chr971454037145463E071-37500
chr971455207146034E071-36929
chr971466027147434E071-35529
chr971474607147548E071-35415
chr971476397148552E071-34411
chr971485847148655E071-34308
chr971488497148899E071-34064
chr971490397149114E071-33849
chr971491627149355E071-33608
chr971494517149580E071-33383
chr971721697172497E071-10466
chr971725027172750E071-10213
chr971727667173088E071-9875
chr971730977173244E071-9719
chr971732877173408E071-9555
chr971918097191883E0718846
chr972098947209948E07126931
chr972102037210301E07127240
chr972103227210372E07127359
chr972108627211223E07127899
chr972112307211311E07128267
chr972113427211542E07128379
chr972128437213230E07129880
chr971466027147434E072-35529
chr971474607147548E072-35415
chr971476397148552E072-34411
chr971491627149355E072-33608
chr971494517149580E072-33383
chr971727667173088E072-9875
chr971730977173244E072-9719
chr972108627211223E07227899
chr972112307211311E07228267
chr972113427211542E07228379
chr971454037145463E073-37500
chr971455207146034E073-36929
chr971462307146397E073-36566
chr971464297146545E073-36418
chr971466027147434E073-35529
chr971474607147548E073-35415
chr971476397148552E073-34411
chr971485847148655E073-34308
chr971721697172497E073-10466
chr971725027172750E073-10213
chr972113427211542E07328379
chr972116947211944E07328731
chr971450047145157E074-37806
chr971466027147434E074-35529
chr971474607147548E074-35415
chr971531647154003E074-28960
chr971673647167439E074-15524
chr971674607167510E074-15453
chr971697987169997E074-12966
chr971700787170331E074-12632
chr971718807172096E074-10867
chr971721697172497E074-10466
chr971725027172750E074-10213
chr971727667173088E074-9875
chr971730977173244E074-9719
chr971732877173408E074-9555
chr972098947209948E07426931
chr972108627211223E07427899
chr972112307211311E07428267
chr972113427211542E07428379
chr971466027147434E081-35529
chr971474607147548E081-35415
chr971713267171866E081-11097
chr971718807172096E081-10867
chr971721697172497E081-10466
chr971725027172750E081-10213
chr972108627211223E08127899
chr972112307211311E08128267
chr972113427211542E08128379
chr971718807172096E082-10867
chr971721697172497E082-10466
chr971725027172750E082-10213
chr971727667173088E082-9875
chr971730977173244E082-9719
chr971774157177743E082-5220
chr972097197209798E08226756










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr972090577209667E06726094
chr972121607212338E06729197
chr972090577209667E06826094
chr972121607212338E06829197
chr972090577209667E06926094
chr972121607212338E06929197
chr972090577209667E07026094
chr972087237208823E07125760
chr972090577209667E07126094
chr972121607212338E07129197
chr972087237208823E07225760
chr972090577209667E07226094
chr972121607212338E07229197
chr972090577209667E07326094
chr972121607212338E07329197
chr972087237208823E07425760
chr972090577209667E07426094
chr972121607212338E07429197
chr972090577209667E08226094