rs787176

Organism: Homo sapiens

Alleles: C>T

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

C==0340 (10190/29942,GnomAD)
C==0350 (10201/29118,TOPMED)
C==0371 (1857/5008,1000G)
C==0317 (1222/3854,ALSPAC)
C==0309 (1145/3708,TWINSUK)

Position: chr2:143910681 (GRCh38.p7) (2q22.3)

Phenotype: ND

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 56 Enhancers around

Promoter: 9 Promoters around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 2	NC_000002.12:g.143910681C>T
GRCh37.p13 chr 2	NC_000002.11:g.144668249C>T

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	C=0.387	T=0.613
1000Genomes	American	Sub	694	C=0.290	T=0.710
1000Genomes	East Asian	Sub	1008	C=0.403	T=0.597
1000Genomes	Europe	Sub	1006	C=0.325	T=0.675
1000Genomes	Global	Study-wide	5008	C=0.371	T=0.629
1000Genomes	South Asian	Sub	978	C=0.420	T=0.580
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	C=0.317	T=0.683
The Genome Aggregation Database	African	Sub	8724	C=0.390	T=0.610
The Genome Aggregation Database	American	Sub	838	C=0.280	T=0.720
The Genome Aggregation Database	East Asian	Sub	1612	C=0.362	T=0.638
The Genome Aggregation Database	Europe	Sub	18466	C=0.317	T=0.682
The Genome Aggregation Database	Global	Study-wide	29942	C=0.340	T=0.659
The Genome Aggregation Database	Other	Sub	302	C=0.340	T=0.660
Trans-Omics for Precision Medicine	Global	Study-wide	29118	C=0.350	T=0.649
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	C=0.309	T=0.691

PMID	Title	Author	Journal
23542338	A genomewide association study of smoking relapse in four European population-based samples.	Tozzi F	Psychiatr Genet

SNP ID	p-value	Traits	Study
rs787176	6.05E-07	nicotine dependence (smoking)	23542338

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr2	144695982	144696253	E067	27733
chr2	144696388	144696506	E067	28139
chr2	144696903	144698125	E068	28654
chr2	144695982	144696253	E069	27733
chr2	144649329	144650013	E070	-18236
chr2	144695982	144696253	E070	27733
chr2	144696388	144696506	E070	28139
chr2	144696537	144696637	E070	28288
chr2	144696639	144696731	E070	28390
chr2	144696783	144696845	E070	28534
chr2	144696903	144698125	E070	28654
chr2	144711200	144711732	E071	42951
chr2	144713353	144713605	E071	45104
chr2	144661137	144661339	E072	-6910
chr2	144713353	144713605	E072	45104
chr2	144698164	144698234	E074	29915
chr2	144632817	144632935	E081	-35314
chr2	144633055	144633105	E081	-35144
chr2	144633168	144633470	E081	-34779
chr2	144634716	144634950	E081	-33299
chr2	144635280	144635413	E081	-32836
chr2	144695982	144696253	E081	27733
chr2	144696388	144696506	E081	28139
chr2	144696537	144696637	E081	28288
chr2	144696639	144696731	E081	28390
chr2	144696783	144696845	E081	28534
chr2	144696903	144698125	E081	28654
chr2	144698164	144698234	E081	29915
chr2	144698319	144698369	E081	30070
chr2	144702626	144702703	E081	34377
chr2	144703445	144703495	E081	35196
chr2	144707288	144707400	E081	39039
chr2	144707426	144707586	E081	39177
chr2	144707833	144707893	E081	39584
chr2	144708037	144708109	E081	39788
chr2	144709080	144709242	E081	40831
chr2	144709395	144709445	E081	41146
chr2	144710721	144710895	E081	42472
chr2	144710967	144711194	E081	42718
chr2	144711200	144711732	E081	42951
chr2	144711805	144712133	E081	43556
chr2	144712309	144712358	E081	44060
chr2	144712388	144712542	E081	44139
chr2	144712602	144712665	E081	44353
chr2	144712828	144713328	E081	44579
chr2	144713353	144713605	E081	45104
chr2	144714393	144714553	E081	46144
chr2	144646757	144647213	E082	-21036
chr2	144696903	144698125	E082	28654
chr2	144698164	144698234	E082	29915
chr2	144698319	144698369	E082	30070
chr2	144703445	144703495	E082	35196
chr2	144710721	144710895	E082	42472
chr2	144710967	144711194	E082	42718
chr2	144712828	144713328	E082	44579
chr2	144713353	144713605	E082	45104

Promoter Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr2	144692745	144695958	E067	24496
chr2	144692745	144695958	E068	24496
chr2	144692745	144695958	E069	24496
chr2	144692745	144695958	E070	24496
chr2	144692745	144695958	E071	24496
chr2	144692745	144695958	E072	24496
chr2	144692745	144695958	E073	24496
chr2	144692745	144695958	E074	24496
chr2	144692745	144695958	E082	24496

rs787176

Genomic Coordinates

Population Frequency

P-Value

eQTL of rs787176 in Brain tissues (GTEx Analysis Release V7)

meQTL of rs787176 in Fetal Brain

Genomic View

Chromatin Interaction

Enhancer Annotation (GRCh37.p13)

Promoter Annotation (GRCh37.p13)