rs7963376

Homo sapiens
T>C
WNK1 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0499 (14941/29890,GnomAD)
C=0464 (13530/29118,TOPMED)
T==0461 (2311/5008,1000G)
T==0464 (1787/3854,ALSPAC)
T==0462 (1713/3708,TWINSUK)
chr12:817082 (GRCh38.p7) (12p13.33)
AD
GWASdb2
1   publication(s)
See rs on genome
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 12NC_000012.12:g.817082T>C
GRCh37.p13 chr 12NC_000012.11:g.926248T>C
WNK1 RefSeqGeneNG_007984.3:g.69024T>C

Gene: WNK1, WNK lysine deficient protein kinase 1(plus strand)

Molecule type Change Amino acid[Codon] SO Term
WNK1 transcript variant 4NM_001184985.1:c.N/AIntron Variant
WNK1 transcript variant 2NM_014823.2:c.N/AIntron Variant
WNK1 transcript variant 1NM_018979.3:c.N/AIntron Variant
WNK1 transcript variant 3NM_213655.4:c.N/AIntron Variant
WNK1 transcript variant X10XM_006719003.2:c.N/AIntron Variant
WNK1 transcript variant X1XM_011520997.2:c.N/AIntron Variant
WNK1 transcript variant X2XM_011520998.2:c.N/AIntron Variant
WNK1 transcript variant X3XM_011520999.2:c.N/AIntron Variant
WNK1 transcript variant X4XM_011521000.2:c.N/AIntron Variant
WNK1 transcript variant X5XM_011521001.2:c.N/AIntron Variant
WNK1 transcript variant X6XM_011521002.2:c.N/AIntron Variant
WNK1 transcript variant X7XM_011521003.2:c.N/AIntron Variant
WNK1 transcript variant X8XM_011521004.2:c.N/AIntron Variant
WNK1 transcript variant X11XM_011521006.2:c.N/AIntron Variant
WNK1 transcript variant X12XM_011521007.2:c.N/AIntron Variant
WNK1 transcript variant X18XM_011521008.2:c.N/AIntron Variant
WNK1 transcript variant X19XM_011521009.2:c.N/AIntron Variant
WNK1 transcript variant X13XM_017019834.1:c.N/AIntron Variant
WNK1 transcript variant X14XM_017019835.1:c.N/AIntron Variant
WNK1 transcript variant X15XM_017019836.1:c.N/AIntron Variant
WNK1 transcript variant X16XM_017019837.1:c.N/AIntron Variant
WNK1 transcript variant X17XM_017019838.1:c.N/AIntron Variant
WNK1 transcript variant X20XM_017019839.1:c.N/AIntron Variant
WNK1 transcript variant X9XM_011521005.2:c.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.661C=0.339
1000GenomesAmericanSub694T=0.390C=0.610
1000GenomesEast AsianSub1008T=0.196C=0.804
1000GenomesEuropeSub1006T=0.492C=0.508
1000GenomesGlobalStudy-wide5008T=0.461C=0.539
1000GenomesSouth AsianSub978T=0.480C=0.520
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.464C=0.536
The Genome Aggregation DatabaseAfricanSub8696T=0.611C=0.389
The Genome Aggregation DatabaseAmericanSub838T=0.360C=0.640
The Genome Aggregation DatabaseEast AsianSub1612T=0.189C=0.811
The Genome Aggregation DatabaseEuropeSub18442T=0.479C=0.520
The Genome Aggregation DatabaseGlobalStudy-wide29890T=0.500C=0.499
The Genome Aggregation DatabaseOtherSub302T=0.580C=0.420
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.535C=0.464
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.462C=0.538
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs79633760.00055alcohol dependence20201924

eQTL of rs7963376 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr12:926248RAD52ENSG00000002016.12T>C2.7481e-7-172971Cortex

meQTL of rs7963376 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr12882617882657E067-43591
chr12882840882930E067-43318
chr12883207883731E067-42517
chr12883945884035E067-42213
chr12884976885123E067-41125
chr12885151885316E067-40932
chr12885907885962E067-40286
chr12886033886214E067-40034
chr12887957888043E067-38205
chr12888088888336E067-37912
chr12888408888482E067-37766
chr12888943889165E067-37083
chr12889191889296E067-36952
chr12889534889920E067-36328
chr12889965890237E067-36011
chr12890280890390E067-35858
chr12890436890537E067-35711
chr12890568890618E067-35630
chr12898043898294E067-27954
chr12898377898428E067-27820
chr12898612898673E067-27575
chr12898719898820E067-27428
chr12898911899380E067-26868
chr12899479899634E067-26614
chr12899681899840E067-26408
chr12899855899964E067-26284
chr12900035900122E067-26126
chr12902239902454E067-23794
chr12911469911651E067-14597
chr12911914912080E067-14168
chr12913841913938E067-12310
chr12913973914034E067-12214
chr12914246914514E067-11734
chr12914527914590E067-11658
chr12919303919353E067-6895
chr12919875920100E067-6148
chr12920242920303E067-5945
chr12920601920657E067-5591
chr12920822920975E067-5273
chr12921098921190E067-5058
chr12921402921617E067-4631
chr12921642921765E067-4483
chr12927856927932E0671608
chr12927971928207E0671723
chr12938392938442E06712144
chr12938466938520E06712218
chr12938692938757E06712444
chr12960505960830E06734257
chr12961653961729E06735405
chr12964528964568E06738280
chr12964673964764E06738425
chr12877043877142E068-49106
chr12877699877742E068-48506
chr12883207883731E068-42517
chr12883945884035E068-42213
chr12884711884903E068-41345
chr12884976885123E068-41125
chr12885151885316E068-40932
chr12885907885962E068-40286
chr12886033886214E068-40034
chr12886901887129E068-39119
chr12887173887266E068-38982
chr12887957888043E068-38205
chr12888943889165E068-37083
chr12889191889296E068-36952
chr12889306889490E068-36758
chr12889534889920E068-36328
chr12889965890237E068-36011
chr12890280890390E068-35858
chr12894998895172E068-31076
chr12896053896115E068-30133
chr12898377898428E068-27820
chr12898612898673E068-27575
chr12898719898820E068-27428
chr12898911899380E068-26868
chr12899479899634E068-26614
chr12899681899840E068-26408
chr12899855899964E068-26284
chr12900978901048E068-25200
chr12901072901219E068-25029
chr12901265901460E068-24788
chr12902088902138E068-24110
chr12902239902454E068-23794
chr12902697902755E068-23493
chr12905177905227E068-21021
chr12905517905650E068-20598
chr12905909905969E068-20279
chr12905994906034E068-20214
chr12913317913492E068-12756
chr12913602913651E068-12597
chr12913841913938E068-12310
chr12913973914034E068-12214
chr12914246914514E068-11734
chr12914527914590E068-11658
chr12915347916237E068-10011
chr12919770919826E068-6422
chr12919875920100E068-6148
chr12920242920303E068-5945
chr12920601920657E068-5591
chr12920822920975E068-5273
chr12921098921190E068-5058
chr12921402921617E068-4631
chr12921642921765E068-4483
chr12927650927700E0681402
chr12927856927932E0681608
chr12927971928207E0681723
chr12938392938442E06812144
chr12938466938520E06812218
chr12938692938757E06812444
chr12938961939030E06812713
chr12939079939119E06812831
chr12939159939199E06812911
chr12943611943655E06817363
chr12960252960333E06834004
chr12960505960830E06834257
chr12961157961392E06834909
chr12964140964238E06837892
chr12964528964568E06838280
chr12966586967203E06840338
chr12876749876947E069-49301
chr12877043877142E069-49106
chr12877225877305E069-48943
chr12877310877422E069-48826
chr12883207883731E069-42517
chr12884552884644E069-41604
chr12884711884903E069-41345
chr12884976885123E069-41125
chr12885151885316E069-40932
chr12888943889165E069-37083
chr12889191889296E069-36952
chr12889306889490E069-36758
chr12889534889920E069-36328
chr12889965890237E069-36011
chr12890280890390E069-35858
chr12890436890537E069-35711
chr12890568890618E069-35630
chr12891270891320E069-34928
chr12891372891422E069-34826
chr12891437891560E069-34688
chr12894224894545E069-31703
chr12896053896115E069-30133
chr12896670896710E069-29538
chr12896772896816E069-29432
chr12896820896908E069-29340
chr12896946896993E069-29255
chr12898719898820E069-27428
chr12898911899380E069-26868
chr12899479899634E069-26614
chr12899681899840E069-26408
chr12899855899964E069-26284
chr12900035900122E069-26126
chr12904239904289E069-21959
chr12904317904361E069-21887
chr12904379904440E069-21808
chr12904560904795E069-21453
chr12904800904894E069-21354
chr12904994905044E069-21204
chr12905177905227E069-21021
chr12911047911194E069-15054
chr12911469911651E069-14597
chr12915347916237E069-10011
chr12916267916365E069-9883
chr12916565916834E069-9414
chr12919770919826E069-6422
chr12919875920100E069-6148
chr12920242920303E069-5945
chr12921402921617E069-4631
chr12921642921765E069-4483
chr12927650927700E0691402
chr12927856927932E0691608
chr12960505960830E06934257
chr12961157961392E06934909
chr12961443961535E06935195
chr12961653961729E06935405
chr12961930962409E06935682
chr12966378966428E06940130
chr12966586967203E06940338
chr12967339967438E06941091
chr12967520967614E06941272
chr12967620967734E06941372
chr12919770919826E070-6422
chr12919875920100E070-6148
chr12920242920303E070-5945
chr12921402921617E070-4631
chr12921642921765E070-4483
chr12878982879093E071-47155
chr12881364881514E071-44734
chr12882496882546E071-43702
chr12882617882657E071-43591
chr12882840882930E071-43318
chr12883207883731E071-42517
chr12884711884903E071-41345
chr12884976885123E071-41125
chr12885151885316E071-40932
chr12885907885962E071-40286
chr12886033886214E071-40034
chr12886901887129E071-39119
chr12887173887266E071-38982
chr12887957888043E071-38205
chr12888088888336E071-37912
chr12888408888482E071-37766
chr12888943889165E071-37083
chr12889191889296E071-36952
chr12889306889490E071-36758
chr12889534889920E071-36328
chr12889965890237E071-36011
chr12890280890390E071-35858
chr12890436890537E071-35711
chr12890568890618E071-35630
chr12891270891320E071-34928
chr12891372891422E071-34826
chr12891437891560E071-34688
chr12894224894545E071-31703
chr12896053896115E071-30133
chr12898043898294E071-27954
chr12898377898428E071-27820
chr12898612898673E071-27575
chr12898719898820E071-27428
chr12898911899380E071-26868
chr12899479899634E071-26614
chr12899681899840E071-26408
chr12899855899964E071-26284
chr12900035900122E071-26126
chr12900429900521E071-25727
chr12900554900606E071-25642
chr12900717900757E071-25491
chr12900832900872E071-25376
chr12900978901048E071-25200
chr12901072901219E071-25029
chr12901265901460E071-24788
chr12901672901754E071-24494
chr12902088902138E071-24110
chr12902239902454E071-23794
chr12902697902755E071-23493
chr12902988903038E071-23210
chr12904379904440E071-21808
chr12904560904795E071-21453
chr12904800904894E071-21354
chr12904994905044E071-21204
chr12905177905227E071-21021
chr12905517905650E071-20598
chr12909905910134E071-16114
chr12910321910434E071-15814
chr12911047911194E071-15054
chr12911469911651E071-14597
chr12911914912080E071-14168
chr12912159912257E071-13991
chr12912378912462E071-13786
chr12913317913492E071-12756
chr12913602913651E071-12597
chr12913841913938E071-12310
chr12913973914034E071-12214
chr12914246914514E071-11734
chr12914527914590E071-11658
chr12915347916237E071-10011
chr12916267916365E071-9883
chr12919770919826E071-6422
chr12919875920100E071-6148
chr12920242920303E071-5945
chr12921098921190E071-5058
chr12921402921617E071-4631
chr12921642921765E071-4483
chr12925560926070E071-178
chr12926137926321E0710
chr12927125927647E071877
chr12927650927700E0711402
chr12927856927932E0711608
chr12927971928207E0711723
chr12928318928368E0712070
chr12928490928530E0712242
chr12928602928642E0712354
chr12928658928709E0712410
chr12938392938442E07112144
chr12938466938520E07112218
chr12938692938757E07112444
chr12938961939030E07112713
chr12939079939119E07112831
chr12939159939199E07112911
chr12943611943655E07117363
chr12957676957973E07131428
chr12958016958115E07131768
chr12958165958263E07131917
chr12958271958367E07132023
chr12958436958506E07132188
chr12958553958603E07132305
chr12960252960333E07134004
chr12960505960830E07134257
chr12961157961392E07134909
chr12961443961535E07135195
chr12961653961729E07135405
chr12961930962409E07135682
chr12962595962707E07136347
chr12876268876318E072-49930
chr12876455876505E072-49743
chr12876687876731E072-49517
chr12876749876947E072-49301
chr12877043877142E072-49106
chr12877225877305E072-48943
chr12877310877422E072-48826
chr12883207883731E072-42517
chr12884552884644E072-41604
chr12884711884903E072-41345
chr12884976885123E072-41125
chr12885151885316E072-40932
chr12886901887129E072-39119
chr12887173887266E072-38982
chr12888943889165E072-37083
chr12889191889296E072-36952
chr12889306889490E072-36758
chr12889534889920E072-36328
chr12889965890237E072-36011
chr12890280890390E072-35858
chr12890436890537E072-35711
chr12890568890618E072-35630
chr12898911899380E072-26868
chr12900035900122E072-26126
chr12902988903038E072-23210
chr12903060903113E072-23135
chr12903407903567E072-22681
chr12904800904894E072-21354
chr12904994905044E072-21204
chr12905177905227E072-21021
chr12919875920100E072-6148
chr12920242920303E072-5945
chr12927856927932E0721608
chr12927971928207E0721723
chr12939079939119E07212831
chr12939159939199E07212911
chr12939246939329E07212998
chr12939344939415E07213096
chr12939687939727E07213439
chr12960505960830E07234257
chr12964528964568E07238280
chr12964673964764E07238425
chr12966586967203E07240338
chr12967339967438E07241091
chr12967520967614E07241272
chr12967620967734E07241372
chr12877043877142E073-49106
chr12877225877305E073-48943
chr12877310877422E073-48826
chr12883207883731E073-42517
chr12884711884903E073-41345
chr12884976885123E073-41125
chr12885151885316E073-40932
chr12889534889920E073-36328
chr12889965890237E073-36011
chr12890280890390E073-35858
chr12896670896710E073-29538
chr12896772896816E073-29432
chr12896820896908E073-29340
chr12896946896993E073-29255
chr12898043898294E073-27954
chr12898377898428E073-27820
chr12898612898673E073-27575
chr12898719898820E073-27428
chr12898911899380E073-26868
chr12902239902454E073-23794
chr12902697902755E073-23493
chr12919770919826E073-6422
chr12919875920100E073-6148
chr12927856927932E0731608
chr12960505960830E07334257
chr12877043877142E074-49106
chr12877225877305E074-48943
chr12877310877422E074-48826
chr12883207883731E074-42517
chr12885151885316E074-40932
chr12885907885962E074-40286
chr12886033886214E074-40034
chr12886901887129E074-39119
chr12887173887266E074-38982
chr12887957888043E074-38205
chr12888088888336E074-37912
chr12888408888482E074-37766
chr12888943889165E074-37083
chr12889191889296E074-36952
chr12889306889490E074-36758
chr12889534889920E074-36328
chr12889965890237E074-36011
chr12890280890390E074-35858
chr12890436890537E074-35711
chr12890568890618E074-35630
chr12898043898294E074-27954
chr12898377898428E074-27820
chr12898612898673E074-27575
chr12898719898820E074-27428
chr12898911899380E074-26868
chr12899479899634E074-26614
chr12899681899840E074-26408
chr12899855899964E074-26284
chr12900035900122E074-26126
chr12902239902454E074-23794
chr12902697902755E074-23493
chr12902988903038E074-23210
chr12903060903113E074-23135
chr12903407903567E074-22681
chr12903993904043E074-22205
chr12904239904289E074-21959
chr12904317904361E074-21887
chr12904379904440E074-21808
chr12904560904795E074-21453
chr12904800904894E074-21354
chr12904994905044E074-21204
chr12905177905227E074-21021
chr12905517905650E074-20598
chr12911469911651E074-14597
chr12911914912080E074-14168
chr12912159912257E074-13991
chr12912378912462E074-13786
chr12914246914514E074-11734
chr12914527914590E074-11658
chr12915168915210E074-11038
chr12915347916237E074-10011
chr12916267916365E074-9883
chr12916565916834E074-9414
chr12919303919353E074-6895
chr12919770919826E074-6422
chr12919875920100E074-6148
chr12920242920303E074-5945
chr12920601920657E074-5591
chr12920822920975E074-5273
chr12921098921190E074-5058
chr12921402921617E074-4631
chr12921642921765E074-4483
chr12921808921848E074-4400
chr12927125927647E074877
chr12927650927700E0741402
chr12927856927932E0741608
chr12927971928207E0741723
chr12938392938442E07412144
chr12938466938520E07412218
chr12938692938757E07412444
chr12938961939030E07412713
chr12939079939119E07412831
chr12939159939199E07412911
chr12958016958115E07431768
chr12960252960333E07434004
chr12960505960830E07434257
chr12961157961392E07434909
chr12961443961535E07435195
chr12961653961729E07435405
chr12961930962409E07435682
chr12964140964238E07437892
chr12964528964568E07438280
chr12964673964764E07438425
chr12887173887266E082-38982
chr12909905910134E082-16114