rs8016108

Homo sapiens
C>T
LOC107984695 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0123 (3699/29958,GnomAD)
T=0121 (3538/29118,TOPMED)
T=0150 (750/5008,1000G)
T=0109 (422/3854,ALSPAC)
T=0102 (377/3708,TWINSUK)
chr14:71187404 (GRCh38.p7) (14q24.2)
AD
GWASdb2
1   publication(s)
See rs on genome
104 Enhancers around
2 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 14NC_000014.9:g.71187404C>T
GRCh37.p13 chr 14NC_000014.8:g.71654121C>T

Gene: LOC107984695, uncharacterized LOC107984695(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC107984695 transcript variant X1XR_001750806.1:n.N/AIntron Variant
LOC107984695 transcript variant X2XR_001750807.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.871T=0.129
1000GenomesAmericanSub694C=0.700T=0.300
1000GenomesEast AsianSub1008C=0.878T=0.122
1000GenomesEuropeSub1006C=0.870T=0.130
1000GenomesGlobalStudy-wide5008C=0.850T=0.150
1000GenomesSouth AsianSub978C=0.880T=0.120
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.891T=0.109
The Genome Aggregation DatabaseAfricanSub8716C=0.888T=0.112
The Genome Aggregation DatabaseAmericanSub838C=0.700T=0.300
The Genome Aggregation DatabaseEast AsianSub1620C=0.885T=0.115
The Genome Aggregation DatabaseEuropeSub18482C=0.878T=0.121
The Genome Aggregation DatabaseGlobalStudy-wide29958C=0.876T=0.123
The Genome Aggregation DatabaseOtherSub302C=0.860T=0.140
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.878T=0.121
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.898T=0.102
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs80161080.000502alcohol dependence20201924

eQTL of rs8016108 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs8016108 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr147167344871674023E06719327
chr147167675571676929E06722634
chr147167693171677011E06722810
chr147167720071677305E06723079
chr147167735171677439E06723230
chr147167847671678526E06724355
chr147167888771678938E06724766
chr147167909071679130E06724969
chr147160987571610921E068-43200
chr147163026271630446E068-23675
chr147163050071630607E068-23514
chr147163065871630712E068-23409
chr147163085671630906E068-23215
chr147163103671631142E068-22979
chr147163115071631267E068-22854
chr147163139571631506E068-22615
chr147163155171631595E068-22526
chr147167344871674023E06819327
chr147167675571676929E06822634
chr147167693171677011E06822810
chr147167847671678526E06824355
chr147167888771678938E06824766
chr147167909071679130E06824969
chr147167932271679771E06825201
chr147170325271703421E06849131
chr147160525571606355E069-47766
chr147167344871674023E06919327
chr147167462971674699E06920508
chr147167675571676929E06922634
chr147167693171677011E06922810
chr147167720071677305E06923079
chr147167735171677439E06923230
chr147167781971677915E06923698
chr147167792371678061E06923802
chr147167847671678526E06924355
chr147167888771678938E06924766
chr147167909071679130E06924969
chr147167932271679771E06925201
chr147169183571691904E06937714
chr147169190571692137E06937784
chr147169513971695215E06941018
chr147169536671695739E06941245
chr147170262371703013E06948502
chr147170302871703172E06948907
chr147162343471623669E070-30452
chr147162378171623890E070-30231
chr147162391771623957E070-30164
chr147163671471636786E070-17335
chr147163704771637119E070-17002
chr147165061971651224E070-2897
chr147170089371701092E07046772
chr147170131771701440E07047196
chr147170346471703549E07049343
chr147160525571606355E071-47766
chr147167675571676929E07122634
chr147167693171677011E07122810
chr147167720071677305E07123079
chr147167735171677439E07123230
chr147167781971677915E07123698
chr147167792371678061E07123802
chr147167909071679130E07124969
chr147169183571691904E07137714
chr147169190571692137E07137784
chr147160636371606494E072-47627
chr147167299671673082E07218875
chr147167314771673201E07219026
chr147167327871673360E07219157
chr147169183571691904E07237714
chr147169190571692137E07237784
chr147169513971695215E07241018
chr147169536671695739E07241245
chr147170325271703421E07249131
chr147160987571610921E073-43200
chr147167344871674023E07319327
chr147167675571676929E07322634
chr147167693171677011E07322810
chr147167720071677305E07323079
chr147167735171677439E07323230
chr147167909071679130E07324969
chr147169894471699259E07344823
chr147169932571699385E07345204
chr147169954071699681E07345419
chr147170262371703013E07348502
chr147160525571606355E074-47766
chr147167344871674023E07419327
chr147167675571676929E07422634
chr147167693171677011E07422810
chr147167720071677305E07423079
chr147167735171677439E07423230
chr147167909071679130E07424969
chr147169183571691904E07437714
chr147169513971695215E07441018
chr147169536671695739E07441245
chr147170262371703013E07448502
chr147170302871703172E07448907
chr147160525571606355E081-47766
chr147165061971651224E081-2897
chr147165126271651386E081-2735
chr147160525571606355E082-47766
chr147165061971651224E082-2897
chr147170262371703013E08248502
chr147170302871703172E08248907
chr147170325271703421E08249131
chr147170346471703549E08249343










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr147168045171680511E06726330
chr147168045171680511E07326330