rs8019389

Homo sapiens
G>C / G>T
LOC105370547 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0059 (1776/29982,GnomAD)
T=0031 (926/29118,TOPMED)
T=0020 (102/5008,1000G)
T=0065 (250/3854,ALSPAC)
T=0077 (285/3708,TWINSUK)
chr14:68734473 (GRCh38.p7) (14q24.1)
ND
GWASdb2
1   publication(s)
See rs on genome
46 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 14NC_000014.9:g.68734473G>C
GRCh38.p7 chr 14NC_000014.9:g.68734473G>T
GRCh37.p13 chr 14NC_000014.8:g.69201190G>C
GRCh37.p13 chr 14NC_000014.8:g.69201190G>T

Gene: LOC105370547, uncharacterized LOC105370547(plus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105370547 transcriptXR_001750995.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.997T=0.003
1000GenomesAmericanSub694G=0.980T=0.020
1000GenomesEast AsianSub1008G=1.000T=0.000
1000GenomesEuropeSub1006G=0.924T=0.076
1000GenomesGlobalStudy-wide5008G=0.980T=0.020
1000GenomesSouth AsianSub978G=0.990T=0.010
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.935T=0.065
The Genome Aggregation DatabaseAfricanSub8728G=0.988T=0.012
The Genome Aggregation DatabaseAmericanSub838G=0.980T=0.02,
The Genome Aggregation DatabaseEast AsianSub1622G=1.000T=0.000
The Genome Aggregation DatabaseEuropeSub18492G=0.911T=0.088
The Genome Aggregation DatabaseGlobalStudy-wide29982G=0.940T=0.059
The Genome Aggregation DatabaseOtherSub302G=0.950T=0.05,
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.968T=0.031
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.923T=0.077
PMID Title Author Journal
20158304A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.Lind PATwin Res Hum Genet

P-Value

SNP ID p-value Traits Study
rs80193891.96E-05alcohol and nictotine co-dependence20158304

eQTL of rs8019389 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs8019389 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr143920697739207185E067-45837
chr143920719239207310E067-45712
chr143923913039239204E067-13818
chr143923926539239340E067-13682
chr143923944539239905E067-13117
chr143924275239242855E067-10167
chr143929922339299263E06746201
chr143920697739207185E068-45837
chr143920719239207310E068-45712
chr143920735739207488E068-45534
chr143920754039207612E068-45410
chr143923944539239905E068-13117
chr143928952039289570E06836498
chr143920681539206863E069-46159
chr143920697739207185E069-45837
chr143920719239207310E069-45712
chr143920735739207488E069-45534
chr143920754039207612E069-45410
chr143920762039207670E069-45352
chr143924405239244102E069-8920
chr143924417339244215E069-8807
chr143921385139213891E070-39131
chr143921392139214087E070-38935
chr143921442539214475E070-38547
chr143921506839215469E070-37553
chr143921593939215996E070-37026
chr143920681539206863E071-46159
chr143920697739207185E071-45837
chr143920719239207310E071-45712
chr143920735739207488E071-45534
chr143920754039207612E071-45410
chr143920762039207670E071-45352
chr143920816139208264E071-44758
chr143928952039289570E07136498
chr143920697739207185E072-45837
chr143920719239207310E072-45712
chr143920735739207488E072-45534
chr143920754039207612E072-45410
chr143929512439295296E07242102
chr143920681539206863E074-46159
chr143920697739207185E074-45837
chr143920754039207612E074-45410
chr143923944539239905E074-13117
chr143924405239244102E074-8920
chr143924417339244215E074-8807
chr143924429939244456E074-8566