rs8024461

Homo sapiens
G>A
CASC4 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G==0397 (11899/29956,GnomAD)
G==0334 (9742/29118,TOPMED)
G==0333 (1667/5008,1000G)
G==0493 (1901/3854,ALSPAC)
G==0490 (1816/3708,TWINSUK)
chr15:44290688 (GRCh38.p7) (15q15.3)
AD
GWASdb2
1   publication(s)
See rs on genome
111 Enhancers around
10 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 15NC_000015.10:g.44290688G>A
GRCh37.p13 chr 15NC_000015.9:g.44582886G>A

Gene: CASC4, cancer susceptibility candidate 4(plus strand)

Molecule type Change Amino acid[Codon] SO Term
CASC4 transcript variant 1NM_138423.3:c.N/AIntron Variant
CASC4 transcript variant 2NM_177974.2:c.N/AIntron Variant
CASC4 transcript variant X2XM_017021880.1:c.N/AIntron Variant
CASC4 transcript variant X1XR_001751066.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.023A=0.977
1000GenomesAmericanSub694G=0.540A=0.460
1000GenomesEast AsianSub1008G=0.394A=0.606
1000GenomesEuropeSub1006G=0.501A=0.499
1000GenomesGlobalStudy-wide5008G=0.333A=0.667
1000GenomesSouth AsianSub978G=0.370A=0.630
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.493A=0.507
The Genome Aggregation DatabaseAfricanSub8720G=0.098A=0.902
The Genome Aggregation DatabaseAmericanSub836G=0.570A=0.430
The Genome Aggregation DatabaseEast AsianSub1616G=0.362A=0.638
The Genome Aggregation DatabaseEuropeSub18484G=0.531A=0.468
The Genome Aggregation DatabaseGlobalStudy-wide29956G=0.397A=0.602
The Genome Aggregation DatabaseOtherSub300G=0.520A=0.480
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.334A=0.665
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.490A=0.510
PMID Title Author Journal
21703634A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.Wang KSJ Psychiatr Res

P-Value

SNP ID p-value Traits Study
rs80244613.17E-05alcohol dependence21703634

eQTL of rs8024461 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs8024461 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr154456721644567315E067-15571
chr154456749644567590E067-15296
chr154456773344567783E067-15103
chr154456779144567912E067-14974
chr154458343244583615E067546
chr154458372844583778E067842
chr154459271344593168E0679827
chr154461622644616350E06733340
chr154456721644567315E068-15571
chr154456749644567590E068-15296
chr154457900444579046E068-3840
chr154457910444579198E068-3688
chr154458343244583615E068546
chr154458372844583778E068842
chr154458386144584050E068975
chr154458829844588507E0685412
chr154458862144588701E0685735
chr154458884044589731E0685954
chr154459271344593168E0689827
chr154459331944593411E06810433
chr154459823544598313E06815349
chr154460683644606935E06823950
chr154460706344607113E06824177
chr154460751044607622E06824624
chr154460791644607966E06825030
chr154453542944535572E069-47314
chr154453563344535763E069-47123
chr154453612644536267E069-46619
chr154456721644567315E069-15571
chr154456749644567590E069-15296
chr154456773344567783E069-15103
chr154456779144567912E069-14974
chr154458343244583615E069546
chr154458372844583778E069842
chr154458386144584050E069975
chr154458788644588202E0695000
chr154458829844588507E0695412
chr154458862144588701E0695735
chr154459809244598172E06915206
chr154459823544598313E06915349
chr154460706344607113E06924177
chr154460751044607622E06924624
chr154457900444579046E070-3840
chr154457910444579198E070-3688
chr154458343244583615E070546
chr154458372844583778E070842
chr154453542944535572E071-47314
chr154453563344535763E071-47123
chr154453612644536267E071-46619
chr154453843444539268E071-43618
chr154456721644567315E071-15571
chr154456749644567590E071-15296
chr154456773344567783E071-15103
chr154456779144567912E071-14974
chr154457900444579046E071-3840
chr154457910444579198E071-3688
chr154458343244583615E071546
chr154458372844583778E071842
chr154458386144584050E071975
chr154458829844588507E0715412
chr154458862144588701E0715735
chr154458884044589731E0715954
chr154459271344593168E0719827
chr154459331944593411E07110433
chr154459360844593686E07110722
chr154460791644607966E07125030
chr154453542944535572E072-47314
chr154453563344535763E072-47123
chr154454278744543675E072-39211
chr154456721644567315E072-15571
chr154456749644567590E072-15296
chr154456773344567783E072-15103
chr154456779144567912E072-14974
chr154458862144588701E0725735
chr154458884044589731E0725954
chr154460706344607113E07224177
chr154460751044607622E07224624
chr154456721644567315E073-15571
chr154456749644567590E073-15296
chr154457900444579046E073-3840
chr154457910444579198E073-3688
chr154458884044589731E0735954
chr154460706344607113E07324177
chr154460751044607622E07324624
chr154453542944535572E074-47314
chr154453563344535763E074-47123
chr154454278744543675E074-39211
chr154456705744567143E074-15743
chr154456721644567315E074-15571
chr154456749644567590E074-15296
chr154456773344567783E074-15103
chr154456779144567912E074-14974
chr154458343244583615E074546
chr154458372844583778E074842
chr154458386144584050E074975
chr154458788644588202E0745000
chr154458829844588507E0745412
chr154458862144588701E0745735
chr154459723244597302E07414346
chr154459809244598172E07415206
chr154459823544598313E07415349
chr154460706344607113E07424177
chr154460751044607622E07424624
chr154453542944535572E081-47314
chr154453563344535763E081-47123
chr154453612644536267E081-46619
chr154457900444579046E081-3840
chr154457910444579198E081-3688
chr154458343244583615E081546
chr154458372844583778E081842
chr154458386144584050E081975









Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr154457973144581950E067-936
chr154457973144581950E068-936
chr154457973144581950E069-936
chr154457973144581950E070-936
chr154457973144581950E071-936
chr154457973144581950E072-936
chr154457973144581950E073-936
chr154457973144581950E074-936
chr154457973144581950E081-936
chr154457973144581950E082-936