rs8108404

Homo sapiens
G>T
ZNF224 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G==0447 (13027/29118,TOPMED)
G==0385 (11108/28852,GnomAD)
G==0471 (2359/5008,1000G)
G==0161 (622/3854,ALSPAC)
G==0165 (611/3708,TWINSUK)
chr19:44099822 (GRCh38.p7) (19q13.31)
AD
GWASdb2
1   publication(s)
See rs on genome
13 Enhancers around
91 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 19NC_000019.10:g.44099822G>T
GRCh37.p13 chr 19NC_000019.9:g.44603975G>T

Gene: ZNF224, zinc finger protein 224(plus strand)

Molecule type Change Amino acid[Codon] SO Term
ZNF224 transcriptNM_001321645.1:c.N/AIntron Variant
ZNF224 transcriptNM_013398.3:c.N/AIntron Variant
ZNF224 transcript variant X1XM_017027261.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.739T=0.261
1000GenomesAmericanSub694G=0.500T=0.500
1000GenomesEast AsianSub1008G=0.479T=0.521
1000GenomesEuropeSub1006G=0.237T=0.763
1000GenomesGlobalStudy-wide5008G=0.471T=0.529
1000GenomesSouth AsianSub978G=0.320T=0.680
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.161T=0.839
The Genome Aggregation DatabaseAfricanSub8546G=0.658T=0.342
The Genome Aggregation DatabaseAmericanSub802G=0.510T=0.490
The Genome Aggregation DatabaseEast AsianSub1610G=0.452T=0.548
The Genome Aggregation DatabaseEuropeSub17598G=0.243T=0.756
The Genome Aggregation DatabaseGlobalStudy-wide28852G=0.385T=0.615
The Genome Aggregation DatabaseOtherSub296G=0.240T=0.760
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.447T=0.552
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.165T=0.835
PMID Title Author Journal
23743675A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.Kapoor MHum Genet

P-Value

SNP ID p-value Traits Study
rs81084045.38E-05alcohol consumption23743675

eQTL of rs8108404 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs8108404 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr194455748644557536E067-46439
chr194455748644557536E068-46439
chr194461888344619034E06814908
chr194460014844600194E069-3781
chr194455793344557994E070-45981
chr194460014844600194E070-3781
chr194461888344619034E07014908
chr194461903744619091E07015062
chr194461912544619165E07015150
chr194461888344619034E07114908
chr194455748644557536E081-46439
chr194455748644557536E082-46439
chr194460081644600930E082-3045







Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr194455479344554904E067-49071
chr194455494844556685E067-47290
chr194455673144556943E067-47032
chr194457541944575610E067-28365
chr194457564244577153E067-26822
chr194459804744599722E067-4253
chr194461592544616789E06711950
chr194461680644618482E06712831
chr194464488144646741E06740906
chr194455494844556685E068-47290
chr194455673144556943E068-47032
chr194457541944575610E068-28365
chr194457564244577153E068-26822
chr194459781244597885E068-6090
chr194459793544597989E068-5986
chr194459804744599722E068-4253
chr194461578744615827E06811812
chr194461592544616789E06811950
chr194461680644618482E06812831
chr194464474344644803E06840768
chr194464488144646741E06840906
chr194455494844556685E069-47290
chr194455673144556943E069-47032
chr194457541944575610E069-28365
chr194457564244577153E069-26822
chr194459804744599722E069-4253
chr194461578744615827E06911812
chr194461592544616789E06911950
chr194461680644618482E06912831
chr194464488144646741E06940906
chr194455494844556685E070-47290
chr194455673144556943E070-47032
chr194457541944575610E070-28365
chr194457564244577153E070-26822
chr194459804744599722E070-4253
chr194461592544616789E07011950
chr194461680644618482E07012831
chr194464474344644803E07040768
chr194464488144646741E07040906
chr194455494844556685E071-47290
chr194455673144556943E071-47032
chr194457541944575610E071-28365
chr194457564244577153E071-26822
chr194459804744599722E071-4253
chr194461578744615827E07111812
chr194461592544616789E07111950
chr194461680644618482E07112831
chr194464474344644803E07140768
chr194464488144646741E07140906
chr194455494844556685E072-47290
chr194455673144556943E072-47032
chr194457541944575610E072-28365
chr194457564244577153E072-26822
chr194459804744599722E072-4253
chr194461592544616789E07211950
chr194461680644618482E07212831
chr194464474344644803E07240768
chr194464488144646741E07240906
chr194455494844556685E073-47290
chr194455673144556943E073-47032
chr194457541944575610E073-28365
chr194457564244577153E073-26822
chr194459804744599722E073-4253
chr194461592544616789E07311950
chr194461680644618482E07312831
chr194464488144646741E07340906
chr194455494844556685E074-47290
chr194455673144556943E074-47032
chr194457541944575610E074-28365
chr194457564244577153E074-26822
chr194459804744599722E074-4253
chr194461592544616789E07411950
chr194461680644618482E07412831
chr194464488144646741E07440906
chr194455494844556685E081-47290
chr194455673144556943E081-47032
chr194457541944575610E081-28365
chr194457564244577153E081-26822
chr194459804744599722E081-4253
chr194461592544616789E08111950
chr194461680644618482E08112831
chr194464488144646741E08140906
chr194455494844556685E082-47290
chr194455673144556943E082-47032
chr194457541944575610E082-28365
chr194457564244577153E082-26822
chr194459804744599722E082-4253
chr194461592544616789E08211950
chr194461680644618482E08212831
chr194464474344644803E08240768
chr194464488144646741E08240906