rs8108432

Organism: Homo sapiens

Alleles: A>G

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

G=0367 (11013/29948,GnomAD)
G=0409 (11911/29118,TOPMED)
G=0499 (2501/5008,1000G)
G=0173 (666/3854,ALSPAC)
G=0172 (636/3708,TWINSUK)

Position: chr19:57023884 (GRCh38.p7) (19q13.43)

Phenotype: AD

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 63 Enhancers around

Promoter: 2 Promoters around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 19	NC_000019.10:g.57023884A>G
GRCh37.p13 chr 19	NC_000019.9:g.57535252A>G

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	A=0.351	G=0.649
1000Genomes	American	Sub	694	A=0.570	G=0.430
1000Genomes	East Asian	Sub	1008	A=0.084	G=0.916
1000Genomes	Europe	Sub	1006	A=0.794	G=0.206
1000Genomes	Global	Study-wide	5008	A=0.501	G=0.499
1000Genomes	South Asian	Sub	978	A=0.780	G=0.220
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	A=0.827	G=0.173
The Genome Aggregation Database	African	Sub	8696	A=0.371	G=0.629
The Genome Aggregation Database	American	Sub	838	A=0.600	G=0.400
The Genome Aggregation Database	East Asian	Sub	1620	A=0.090	G=0.910
The Genome Aggregation Database	Europe	Sub	18492	A=0.800	G=0.199
The Genome Aggregation Database	Global	Study-wide	29948	A=0.632	G=0.367
The Genome Aggregation Database	Other	Sub	302	A=0.810	G=0.190
Trans-Omics for Precision Medicine	Global	Study-wide	29118	A=0.590	G=0.409
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	A=0.828	G=0.172

PMID	Title	Author	Journal
20201924	Genome-wide association study of alcohol dependence implicates a region on chromosome 11.	Edenberg HJ	Alcohol Clin Exp Res

P-Value

SNP ID	p-value	Traits	Study
rs8108432	0.000492	alcohol dependence	20201924

eQTL of rs8108432 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs8108432 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr19	57505144	57505266	E067	-29986
chr19	57505270	57505399	E067	-29853
chr19	57505658	57505909	E067	-29343
chr19	57505144	57505266	E069	-29986
chr19	57505270	57505399	E069	-29853
chr19	57486265	57486540	E070	-48712
chr19	57486548	57486626	E070	-48626
chr19	57486742	57487396	E070	-47856
chr19	57545079	57545242	E070	9827
chr19	57546037	57546550	E070	10785
chr19	57505144	57505266	E072	-29986
chr19	57505270	57505399	E072	-29853
chr19	57505658	57505909	E072	-29343
chr19	57505144	57505266	E074	-29986
chr19	57505270	57505399	E074	-29853
chr19	57505658	57505909	E074	-29343
chr19	57486265	57486540	E081	-48712
chr19	57486548	57486626	E081	-48626
chr19	57486742	57487396	E081	-47856
chr19	57494175	57494575	E081	-40677
chr19	57494615	57494966	E081	-40286
chr19	57495096	57495204	E081	-40048
chr19	57495237	57495287	E081	-39965
chr19	57497405	57497588	E081	-37664
chr19	57497693	57498333	E081	-36919
chr19	57498738	57498894	E081	-36358
chr19	57498896	57498993	E081	-36259
chr19	57499109	57499176	E081	-36076
chr19	57499322	57499447	E081	-35805
chr19	57499506	57499603	E081	-35649
chr19	57499773	57499959	E081	-35293
chr19	57505658	57505909	E081	-29343
chr19	57527452	57527716	E081	-7536
chr19	57545079	57545242	E081	9827
chr19	57545727	57545933	E081	10475
chr19	57546037	57546550	E081	10785
chr19	57562743	57562906	E081	27491
chr19	57563098	57564036	E081	27846
chr19	57564227	57564339	E081	28975
chr19	57564508	57565229	E081	29256
chr19	57565343	57565528	E081	30091
chr19	57565887	57565961	E081	30635
chr19	57566085	57566139	E081	30833
chr19	57579700	57579958	E081	44448
chr19	57583117	57583188	E081	47865
chr19	57486742	57487396	E082	-47856
chr19	57494175	57494575	E082	-40677
chr19	57494615	57494966	E082	-40286
chr19	57497405	57497588	E082	-37664
chr19	57497693	57498333	E082	-36919
chr19	57498738	57498894	E082	-36358
chr19	57498896	57498993	E082	-36259
chr19	57499109	57499176	E082	-36076
chr19	57499322	57499447	E082	-35805
chr19	57499506	57499603	E082	-35649
chr19	57499773	57499959	E082	-35293
chr19	57502720	57502770	E082	-32482
chr19	57561055	57561125	E082	25803
chr19	57562743	57562906	E082	27491
chr19	57563098	57564036	E082	27846
chr19	57564508	57565229	E082	29256
chr19	57565343	57565528	E082	30091
chr19	57583117	57583188	E082	47865

Promoter Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr19	57528088	57528138	E073	-7114
chr19	57528352	57528402	E073	-6850