rs8115863

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
C=0181 (5278/29118,TOPMED)
C=0169 (4818/28410,GnomAD)
C=0195 (975/5008,1000G)
C=0143 (551/3854,ALSPAC)
C=0139 (514/3708,TWINSUK)
chr20:4259862 (GRCh38.p7) (20p13)
AD
GWASdb2
1   publication(s)
See rs on genome
11 Enhancers around
11 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 20NC_000020.11:g.4259862T>C
GRCh37.p13 chr 20NC_000020.10:g.4240509T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.803C=0.197
1000GenomesAmericanSub694T=0.800C=0.200
1000GenomesEast AsianSub1008T=0.690C=0.310
1000GenomesEuropeSub1006T=0.872C=0.128
1000GenomesGlobalStudy-wide5008T=0.805C=0.195
1000GenomesSouth AsianSub978T=0.860C=0.140
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.857C=0.143
The Genome Aggregation DatabaseAfricanSub8394T=0.820C=0.180
The Genome Aggregation DatabaseAmericanSub774T=0.850C=0.150
The Genome Aggregation DatabaseEast AsianSub1564T=0.698C=0.302
The Genome Aggregation DatabaseEuropeSub17382T=0.846C=0.153
The Genome Aggregation DatabaseGlobalStudy-wide28410T=0.830C=0.169
The Genome Aggregation DatabaseOtherSub296T=0.850C=0.150
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.818C=0.181
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.861C=0.139
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs81158630.000083alcohol dependence20201924
rs81158630.0000833alcoholismpha002893

eQTL of rs8115863 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs8115863 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr2042851374285494E07144628
chr2042855494285640E07145040
chr2042857984285999E07145289
chr2042061164207334E073-33175
chr2042074344207727E073-32782
chr2042077654208174E073-32335
chr2042395414239591E081-918
chr2042397664239816E081-693
chr2042845744284686E08144065
chr2042309414231189E082-9320
chr2042845744284686E08244065




Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr2042017224202578E068-37931
chr2042025974202772E068-37737
chr2042295524230603E069-9906
chr2042017224202578E071-37931
chr2042025974202772E071-37737
chr2042295524230603E071-9906
chr2042017224202578E072-37931
chr2042017224202578E074-37931
chr2042017224202578E082-37931
chr2042025974202772E082-37737
chr2042295524230603E082-9906