rs826969

Organism: Homo sapiens

Alleles: G>T

Gene : Feature

ZNF850 : Intron Variant

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

G==0422 (12635/29906,GnomAD)
G==0428 (12481/29118,TOPMED)
T=0451 (2260/5008,1000G)
G==0355 (1369/3854,ALSPAC)
G==0372 (1380/3708,TWINSUK)

Position: chr19:36756570 (GRCh38.p7) (19q13.12)

Phenotype: ND

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 0 Enhancer around

Promoter: 97 Promoters around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 19	NC_000019.10:g.36756570G>T
GRCh37.p13 chr 19	NC_000019.9:g.37247472G>T

Gene: ZNF850, zinc finger protein 850(minus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
ZNF850 transcript variant 1	NM_001193552.1:c.	N/A	Intron Variant
ZNF850 transcript variant 2	NM_001267779.1:c.	N/A	Intron Variant

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.444	T=0.556
1000Genomes	American	Sub	694	G=0.520	T=0.480
1000Genomes	East Asian	Sub	1008	G=0.800	T=0.200
1000Genomes	Europe	Sub	1006	G=0.401	T=0.599
1000Genomes	Global	Study-wide	5008	G=0.549	T=0.451
1000Genomes	South Asian	Sub	978	G=0.600	T=0.400
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.355	T=0.645
The Genome Aggregation Database	African	Sub	8704	G=0.447	T=0.553
The Genome Aggregation Database	American	Sub	834	G=0.580	T=0.420
The Genome Aggregation Database	East Asian	Sub	1610	G=0.785	T=0.215
The Genome Aggregation Database	Europe	Sub	18456	G=0.372	T=0.627
The Genome Aggregation Database	Global	Study-wide	29906	G=0.422	T=0.577
The Genome Aggregation Database	Other	Sub	302	G=0.410	T=0.590
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.428	T=0.571
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.372	T=0.628

PMID	Title	Author	Journal
20158304	A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.	Lind PA	Twin Res Hum Genet

P-Value

SNP ID	p-value	Traits	Study
rs826969	3.15E-05	alcohol and nictotine co-dependence	20158304

eQTL of rs826969 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs826969 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Promoter Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr19	37261836	37264487	E067	14364
chr19	37266204	37266302	E067	18732
chr19	37266446	37266577	E067	18974
chr19	37266582	37266654	E067	19110
chr19	37266720	37267053	E067	19248
chr19	37282402	37282642	E067	34930
chr19	37282753	37283162	E067	35281
chr19	37287739	37288124	E067	40267
chr19	37288178	37288890	E067	40706
chr19	37288940	37289012	E067	41468
chr19	37289055	37289105	E067	41583
chr19	37261713	37261817	E068	14241
chr19	37261836	37264487	E068	14364
chr19	37266446	37266577	E068	18974
chr19	37266582	37266654	E068	19110
chr19	37266720	37267053	E068	19248
chr19	37267216	37267273	E068	19744
chr19	37282186	37282306	E068	34714
chr19	37282402	37282642	E068	34930
chr19	37282753	37283162	E068	35281
chr19	37287121	37287708	E068	39649
chr19	37287739	37288124	E068	40267
chr19	37288178	37288890	E068	40706
chr19	37288940	37289012	E068	41468
chr19	37289055	37289105	E068	41583
chr19	37289451	37289635	E068	41979
chr19	37261713	37261817	E069	14241
chr19	37261836	37264487	E069	14364
chr19	37266446	37266577	E069	18974
chr19	37266582	37266654	E069	19110
chr19	37266720	37267053	E069	19248
chr19	37287121	37287708	E069	39649
chr19	37287739	37288124	E069	40267
chr19	37288178	37288890	E069	40706
chr19	37288940	37289012	E069	41468
chr19	37261713	37261817	E070	14241
chr19	37261836	37264487	E070	14364
chr19	37287739	37288124	E070	40267
chr19	37288178	37288890	E070	40706
chr19	37288940	37289012	E070	41468
chr19	37289055	37289105	E070	41583
chr19	37261713	37261817	E071	14241
chr19	37261836	37264487	E071	14364
chr19	37266446	37266577	E071	18974
chr19	37266582	37266654	E071	19110
chr19	37266720	37267053	E071	19248
chr19	37282402	37282642	E071	34930
chr19	37282753	37283162	E071	35281
chr19	37287121	37287708	E071	39649
chr19	37287739	37288124	E071	40267
chr19	37288178	37288890	E071	40706
chr19	37288940	37289012	E071	41468
chr19	37289055	37289105	E071	41583
chr19	37261713	37261817	E072	14241
chr19	37261836	37264487	E072	14364
chr19	37266204	37266302	E072	18732
chr19	37266446	37266577	E072	18974
chr19	37266582	37266654	E072	19110
chr19	37266720	37267053	E072	19248
chr19	37267216	37267273	E072	19744
chr19	37287739	37288124	E072	40267
chr19	37288178	37288890	E072	40706
chr19	37288940	37289012	E072	41468
chr19	37289055	37289105	E072	41583
chr19	37289451	37289635	E072	41979
chr19	37261713	37261817	E073	14241
chr19	37261836	37264487	E073	14364
chr19	37266204	37266302	E073	18732
chr19	37266446	37266577	E073	18974
chr19	37266582	37266654	E073	19110
chr19	37266720	37267053	E073	19248
chr19	37282402	37282642	E073	34930
chr19	37282753	37283162	E073	35281
chr19	37283624	37283664	E073	36152
chr19	37287739	37288124	E073	40267
chr19	37288178	37288890	E073	40706
chr19	37288940	37289012	E073	41468
chr19	37289055	37289105	E073	41583
chr19	37261713	37261817	E074	14241
chr19	37261836	37264487	E074	14364
chr19	37266204	37266302	E074	18732
chr19	37266446	37266577	E074	18974
chr19	37266582	37266654	E074	19110
chr19	37266720	37267053	E074	19248
chr19	37267216	37267273	E074	19744
chr19	37282186	37282306	E074	34714
chr19	37282402	37282642	E074	34930
chr19	37282753	37283162	E074	35281
chr19	37287739	37288124	E074	40267
chr19	37288178	37288890	E074	40706
chr19	37288940	37289012	E074	41468
chr19	37261713	37261817	E082	14241
chr19	37261836	37264487	E082	14364
chr19	37287739	37288124	E082	40267
chr19	37288178	37288890	E082	40706
chr19	37288940	37289012	E082	41468
chr19	37289055	37289105	E082	41583