rs827330

Homo sapiens
A>C
None
Check p-value
SNV (Single Nucleotide Variation)
A==0145 (4342/29872,GnomAD)
A==0151 (4401/29118,TOPMED)
A==0182 (911/5008,1000G)
A==0119 (460/3854,ALSPAC)
A==0118 (437/3708,TWINSUK)
chr10:70917835 (GRCh38.p7) (10q22.1)
ND
GWASdb2
1   publication(s)
See rs on genome
107 Enhancers around
9 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 10NC_000010.11:g.70917835A>C
GRCh37.p13 chr 10NC_000010.10:g.72677592A>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.140C=0.860
1000GenomesAmericanSub694A=0.110C=0.890
1000GenomesEast AsianSub1008A=0.346C=0.654
1000GenomesEuropeSub1006A=0.118C=0.882
1000GenomesGlobalStudy-wide5008A=0.182C=0.818
1000GenomesSouth AsianSub978A=0.180C=0.820
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.119C=0.881
The Genome Aggregation DatabaseAfricanSub8696A=0.158C=0.842
The Genome Aggregation DatabaseAmericanSub836A=0.110C=0.890
The Genome Aggregation DatabaseEast AsianSub1612A=0.397C=0.603
The Genome Aggregation DatabaseEuropeSub18426A=0.117C=0.882
The Genome Aggregation DatabaseGlobalStudy-wide29872A=0.145C=0.854
The Genome Aggregation DatabaseOtherSub302A=0.220C=0.780
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.151C=0.848
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.118C=0.882
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs8273300.000885nicotine dependence17158188

eQTL of rs827330 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs827330 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr107265021772650394E067-27198
chr107265043172650486E067-27106
chr107265052472651452E067-26140
chr107266298772663530E067-14062
chr107269024172690375E06712649
chr107269039072690482E06712798
chr107269048772690850E06712895
chr107269086272691152E06713270
chr107269116572691472E06713573
chr107269152472691580E06713932
chr107264908472649146E068-28446
chr107265043172650486E068-27106
chr107265052472651452E068-26140
chr107267907072679242E0681478
chr107267933472679374E0681742
chr107264582572645888E069-31704
chr107264589972645947E069-31645
chr107264595772646051E069-31541
chr107264608372646317E069-31275
chr107264634772646538E069-31054
chr107264664272646734E069-30858
chr107264885872648932E069-28660
chr107265043172650486E069-27106
chr107265052472651452E069-26140
chr107269024172690375E06912649
chr107269039072690482E06912798
chr107269048772690850E06912895
chr107264664272646734E070-30858
chr107267702672677076E070-516
chr107267708872677175E070-417
chr107267888872679034E0701296
chr107267907072679242E0701478
chr107267933472679374E0701742
chr107268531472685853E0707722
chr107268585972685962E0708267
chr107270853772708577E07030945
chr107270995772710143E07032365
chr107271045972710526E07032867
chr107271061772710839E07033025
chr107272651972726761E07048927
chr107265043172650486E071-27106
chr107265052472651452E071-26140
chr107265147472651665E071-25927
chr107268585972685962E0718267
chr107268596872686972E0718376
chr107269024172690375E07112649
chr107269039072690482E07112798
chr107269048772690850E07112895
chr107269086272691152E07113270
chr107263947972640200E072-37392
chr107264885872648932E072-28660
chr107264908472649146E072-28446
chr107265021772650394E072-27198
chr107265043172650486E072-27106
chr107265052472651452E072-26140
chr107266298772663530E072-14062
chr107269024172690375E07212649
chr107269039072690482E07212798
chr107269048772690850E07212895
chr107264608372646317E073-31275
chr107264634772646538E073-31054
chr107264664272646734E073-30858
chr107264885872648932E073-28660
chr107265052472651452E073-26140
chr107264634772646538E074-31054
chr107264664272646734E074-30858
chr107265021772650394E074-27198
chr107265043172650486E074-27106
chr107265052472651452E074-26140
chr107269024172690375E07412649
chr107269039072690482E07412798
chr107269048772690850E07412895
chr107269086272691152E07413270
chr107266680272667306E081-10286
chr107266748672667636E081-9956
chr107266778272667876E081-9716
chr107266789572667952E081-9640
chr107267277072672827E081-4765
chr107267290572673089E081-4503
chr107267311972673228E081-4364
chr107267332672673514E081-4078
chr107267353372673600E081-3992
chr107267702672677076E081-516
chr107267708872677175E081-417
chr107267722572677364E081-228
chr107267738772677472E081-120
chr107267748072677576E081-16
chr107267758672677660E0810
chr107268487872684933E0817286
chr107268531472685853E0817722
chr107268585972685962E0818267
chr107268596872686972E0818376
chr107268698272687042E0819390
chr107268705572687347E0819463
chr107269173572691829E08114143
chr107269197072692045E08114378
chr107269222272692500E08114630
chr107267702672677076E082-516
chr107267708872677175E082-417
chr107267722572677364E082-228
chr107267738772677472E082-120
chr107267748072677576E082-16
chr107267758672677660E0820
chr107268531472685853E0827722
chr107268585972685962E0828267
chr107268596872686972E0828376
chr107268698272687042E0829390










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr107264681872648796E067-28796
chr107264681872648796E068-28796
chr107264681872648796E069-28796
chr107264681872648796E070-28796
chr107264681872648796E071-28796
chr107264681872648796E072-28796
chr107264681872648796E073-28796
chr107264681872648796E074-28796
chr107264681872648796E082-28796