rs837136

Homo sapiens
G>A
MEIS2 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G==0122 (3684/29980,GnomAD)
G==0134 (3922/29118,TOPMED)
G==0087 (435/5008,1000G)
G==0134 (516/3854,ALSPAC)
G==0126 (469/3708,TWINSUK)
chr15:36920696 (GRCh38.p7) (15q14)
AD
GWASdb2
1   publication(s)
See rs on genome
181 Enhancers around
8 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 15NC_000015.10:g.36920696G>A
GRCh37.p13 chr 15NC_000015.9:g.37212897G>A
MEIS2 RefSeqGeneNG_029108.1:g.185604C>T

Gene: MEIS2, Meis homeobox 2(minus strand)

Molecule type Change Amino acid[Codon] SO Term
MEIS2 transcript variant iNM_001220482.1:c.N/AIntron Variant
MEIS2 transcript variant fNM_002399.3:c.N/AIntron Variant
MEIS2 transcript variant bNM_170674.4:c.N/AIntron Variant
MEIS2 transcript variant cNM_170675.4:c.N/AIntron Variant
MEIS2 transcript variant dNM_170676.4:c.N/AIntron Variant
MEIS2 transcript variant aNM_170677.4:c.N/AIntron Variant
MEIS2 transcript variant gNM_172315.2:c.N/AIntron Variant
MEIS2 transcript variant hNM_172316.2:c.N/AIntron Variant
MEIS2 transcript variant eNR_051953.1:n.N/AIntron Variant
MEIS2 transcript variant X1XM_006720523.1:c.N/AIntron Variant
MEIS2 transcript variant X5XM_006720524.1:c.N/AIntron Variant
MEIS2 transcript variant X6XM_006720525.1:c.N/AIntron Variant
MEIS2 transcript variant X4XM_006720526.2:c.N/AIntron Variant
MEIS2 transcript variant X5XM_006720527.2:c.N/AIntron Variant
MEIS2 transcript variant X9XM_006720529.2:c.N/AIntron Variant
MEIS2 transcript variant X11XM_011521591.2:c.N/AIntron Variant
MEIS2 transcript variant X7XM_017022205.1:c.N/AIntron Variant
MEIS2 transcript variant X8XR_001751290.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.154A=0.846
1000GenomesAmericanSub694G=0.100A=0.900
1000GenomesEast AsianSub1008G=0.014A=0.986
1000GenomesEuropeSub1006G=0.112A=0.888
1000GenomesGlobalStudy-wide5008G=0.087A=0.913
1000GenomesSouth AsianSub978G=0.040A=0.960
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.134A=0.866
The Genome Aggregation DatabaseAfricanSub8718G=0.153A=0.847
The Genome Aggregation DatabaseAmericanSub838G=0.050A=0.950
The Genome Aggregation DatabaseEast AsianSub1622G=0.009A=0.991
The Genome Aggregation DatabaseEuropeSub18500G=0.123A=0.876
The Genome Aggregation DatabaseGlobalStudy-wide29980G=0.122A=0.877
The Genome Aggregation DatabaseOtherSub302G=0.040A=0.960
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.134A=0.865
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.126A=0.874
PMID Title Author Journal
21703634A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.Wang KSJ Psychiatr Res

P-Value

SNP ID p-value Traits Study
rs8371364.22E-05alcohol dependence21703634

eQTL of rs837136 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs837136 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr153720382737204052E067-8845
chr153720406437204188E067-8709
chr153721633237217308E0673435
chr153721737237217784E0674475
chr153718884837189663E068-23234
chr153718981837190035E068-22862
chr153719008337190664E068-22233
chr153719081537191067E068-21830
chr153719108137191191E068-21706
chr153719132537191375E068-21522
chr153719336237193482E068-19415
chr153719538037195522E068-17375
chr153719558637195764E068-17133
chr153719579137195984E068-16913
chr153719600337196727E068-16170
chr153719700837197257E068-15640
chr153719728037197565E068-15332
chr153720382737204052E068-8845
chr153720406437204188E068-8709
chr153720435737204444E068-8453
chr153720451837204716E068-8181
chr153720478537205164E068-7733
chr153720650137206551E068-6346
chr153720669537207553E068-5344
chr153721534037215415E0682443
chr153721557537215625E0682678
chr153721566737215772E0682770
chr153721583637215886E0682939
chr153721633237217308E0683435
chr153721737237217784E0684475
chr153723364937233769E06820752
chr153723458237234739E06821685
chr153723525437235324E06822357
chr153723533937235389E06822442
chr153723543937235542E06822542
chr153723565237235705E06822755
chr153723574837236298E06822851
chr153723633537236427E06823438
chr153723649237236877E06823595
chr153723688237237136E06823985
chr153723726937237384E06824372
chr153723765037237735E06824753
chr153724396637244423E06831069
chr153724465137244819E06831754
chr153725142037251470E06838523
chr153718884837189663E069-23234
chr153718981837190035E069-22862
chr153719008337190664E069-22233
chr153719081537191067E069-21830
chr153719108137191191E069-21706
chr153720358137203672E069-9225
chr153720382737204052E069-8845
chr153720406437204188E069-8709
chr153721557537215625E0692678
chr153721566737215772E0692770
chr153721633237217308E0693435
chr153718537437185561E070-27336
chr153718565337185721E070-27176
chr153718884837189663E070-23234
chr153720358137203672E070-9225
chr153720382737204052E070-8845
chr153720406437204188E070-8709
chr153720435737204444E070-8453
chr153720451837204716E070-8181
chr153720478537205164E070-7733
chr153720989637210078E070-2819
chr153721534037215415E0702443
chr153721557537215625E0702678
chr153721566737215772E0702770
chr153721583637215886E0702939
chr153722685637226906E07013959
chr153722694937226999E07014052
chr153723633537236427E07023438
chr153723649237236877E07023595
chr153723688237237136E07023985
chr153723726937237384E07024372
chr153724073937241080E07027842
chr153724119337241448E07028296
chr153724145737241647E07028560
chr153724396637244423E07031069
chr153724465137244819E07031754
chr153724487637244940E07031979
chr153724504737245238E07032150
chr153724529837245445E07032401
chr153725497037255030E07042073
chr153725723637257299E07044339
chr153725740937257459E07044512
chr153725818237258530E07045285
chr153725858837258707E07045691
chr153720382737204052E071-8845
chr153720406437204188E071-8709
chr153723633537236427E07123438
chr153725231337252412E07139416
chr153718981837190035E072-22862
chr153720382737204052E072-8845
chr153720406437204188E072-8709
chr153721633237217308E0723435
chr153721737237217784E0724475
chr153721583637215886E0732939
chr153721633237217308E0733435
chr153720773537207883E074-5014
chr153720796137208101E074-4796
chr153717368637179338E081-33559
chr153718197837182063E081-30834
chr153718210737182320E081-30577
chr153718522337185316E081-27581
chr153718537437185561E081-27336
chr153718565337185721E081-27176
chr153718981837190035E081-22862
chr153719008337190664E081-22233
chr153719081537191067E081-21830
chr153719108137191191E081-21706
chr153719600337196727E081-16170
chr153719700837197257E081-15640
chr153719728037197565E081-15332
chr153721557537215625E0812678
chr153721566737215772E0812770
chr153721583637215886E0812939
chr153721633237217308E0813435
chr153721737237217784E0814475
chr153721920637219256E0816309
chr153721928337219443E0816386
chr153721957737219878E0816680
chr153722351037223560E08110613
chr153722510337225164E08112206
chr153722526737225383E08112370
chr153722560737225674E08112710
chr153722685637226906E08113959
chr153722694937226999E08114052
chr153722704637227290E08114149
chr153723221937232307E08119322
chr153723249837233546E08119601
chr153723574837236298E08122851
chr153723633537236427E08123438
chr153723649237236877E08123595
chr153723688237237136E08123985
chr153723726937237384E08124372
chr153724059137240668E08127694
chr153724073937241080E08127842
chr153724119337241448E08128296
chr153724145737241647E08128560
chr153724318637243240E08130289
chr153724343837243508E08130541
chr153724396637244423E08131069
chr153724465137244819E08131754
chr153724487637244940E08131979
chr153725647537256515E08143578
chr153725881137259412E08145914
chr153725968837259743E08146791
chr153725977537259870E08146878
chr153718565337185721E082-27176
chr153718620237186291E082-26606
chr153719600337196727E082-16170
chr153719700837197257E082-15640
chr153719728037197565E082-15332
chr153721557537215625E0822678
chr153721566737215772E0822770
chr153721583637215886E0822939
chr153721920637219256E0826309
chr153721928337219443E0826386
chr153721957737219878E0826680
chr153722685637226906E08213959
chr153722694937226999E08214052
chr153722704637227290E08214149
chr153723688237237136E08223985
chr153724016437240218E08227267
chr153724038437240452E08227487
chr153724048837240579E08227591
chr153724059137240668E08227694
chr153724073937241080E08227842
chr153724119337241448E08228296
chr153724145737241647E08228560
chr153724318637243240E08230289
chr153724343837243508E08230541
chr153724560737245764E08232710
chr153725694737257221E08244050
chr153725723637257299E08244339
chr153725740937257459E08244512
chr153725881137259412E08245914
chr153725968837259743E08246791
chr153725977537259870E08246878










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr153717938037181378E068-31519
chr153717938037181378E069-31519
chr153717938037181378E070-31519
chr153717938037181378E071-31519
chr153717938037181378E072-31519
chr153717938037181378E073-31519
chr153716960037171284E082-41613
chr153717938037181378E082-31519