rs837827

Homo sapiens
G>A
LOC105373612 : Intron Variant
LOC151121 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G==0479 (14331/29880,GnomAD)
G==0452 (13166/29118,TOPMED)
A=0475 (2378/5008,1000G)
G==0476 (1834/3854,ALSPAC)
G==0492 (1824/3708,TWINSUK)
chr2:129246578 (GRCh38.p7) (2q21.1)
AD
GWASdb2
1   publication(s)
See rs on genome
20 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 2NC_000002.12:g.129246578G>A
GRCh37.p13 chr 2NC_000002.11:g.130004151G>A

Gene: LOC151121, uncharacterized LOC151121(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LINC01854 transcript variant 1NR_122040.1:n.N/AIntron Variant
LINC01854 transcript variant 2NR_122041.1:n.N/AIntron Variant
LINC01854 transcript variant 3NR_122042.1:n.N/AIntron Variant

Gene: LOC105373612, uncharacterized LOC105373612(plus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105373612 transcriptXR_001739709.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.371A=0.629
1000GenomesAmericanSub694G=0.540A=0.460
1000GenomesEast AsianSub1008G=0.748A=0.252
1000GenomesEuropeSub1006G=0.464A=0.536
1000GenomesGlobalStudy-wide5008G=0.525A=0.475
1000GenomesSouth AsianSub978G=0.560A=0.440
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.476A=0.524
The Genome Aggregation DatabaseAfricanSub8696G=0.408A=0.592
The Genome Aggregation DatabaseAmericanSub836G=0.550A=0.450
The Genome Aggregation DatabaseEast AsianSub1614G=0.803A=0.197
The Genome Aggregation DatabaseEuropeSub18432G=0.482A=0.517
The Genome Aggregation DatabaseGlobalStudy-wide29880G=0.479A=0.520
The Genome Aggregation DatabaseOtherSub302G=0.440A=0.560
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.452A=0.547
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.492A=0.508
PMID Title Author Journal
24962325Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.Kapoor MDrug Alcohol Depend

P-Value

SNP ID p-value Traits Study
rs8378279.77E-07alcohol dependence (age at onset)24962325

eQTL of rs837827 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs837827 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr2129990903129991022E070-13129
chr2129991443129991904E070-12247
chr2129990903129991022E081-13129
chr2129991443129991904E081-12247
chr2129996773129997036E081-7115
chr2130010223130010353E0816072
chr2130010398130011293E0816247
chr2130038915130039052E08134764
chr2130039472130039687E08135321
chr2130039843130039996E08135692
chr2130050579130050658E08146428
chr2130050695130050812E08146544
chr2129996773129997036E082-7115
chr2130010223130010353E0826072
chr2130038591130038845E08234440
chr2130038915130039052E08234764
chr2130039472130039687E08235321
chr2130039843130039996E08235692
chr2130050579130050658E08246428
chr2130050695130050812E08246544