rs844577

Homo sapiens
A>T
SAMD5 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A==0269 (8050/29930,GnomAD)
A==0235 (6868/29118,TOPMED)
A==0218 (1091/5008,1000G)
A==0339 (1305/3854,ALSPAC)
A==0341 (1263/3708,TWINSUK)
chr6:147592924 (GRCh38.p7) (6q24.3)
ND
GWASdb2
1   publication(s)
See rs on genome
20 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 6NC_000006.12:g.147592924A>T
GRCh37.p13 chr 6NC_000006.11:g.147914060A>T

Gene: SAMD5, sterile alpha motif domain containing 5(plus strand)

Molecule type Change Amino acid[Codon] SO Term
SAMD5 transcriptNM_001030060.2:c.N/AGenic Downstream Transcript Variant
SAMD5 transcript variant X1XM_017010850.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.119T=0.881
1000GenomesAmericanSub694A=0.210T=0.790
1000GenomesEast AsianSub1008A=0.227T=0.773
1000GenomesEuropeSub1006A=0.334T=0.666
1000GenomesGlobalStudy-wide5008A=0.218T=0.782
1000GenomesSouth AsianSub978A=0.230T=0.770
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.339T=0.661
The Genome Aggregation DatabaseAfricanSub8712A=0.152T=0.848
The Genome Aggregation DatabaseAmericanSub836A=0.200T=0.800
The Genome Aggregation DatabaseEast AsianSub1612A=0.230T=0.770
The Genome Aggregation DatabaseEuropeSub18468A=0.328T=0.671
The Genome Aggregation DatabaseGlobalStudy-wide29930A=0.269T=0.731
The Genome Aggregation DatabaseOtherSub302A=0.390T=0.610
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.235T=0.764
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.341T=0.659
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs8445770.000167nicotine dependence17158188

eQTL of rs844577 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs844577 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr6147879754147879872E070-34188
chr6147879997147880778E070-33282
chr6147924633147924823E07010573
chr6147925107147925157E07011047
chr6147905560147905612E081-8448
chr6147906542147906626E081-7434
chr6147906709147906804E081-7256
chr6147906955147907730E081-6330
chr6147908923147909155E081-4905
chr6147909176147909313E081-4747
chr6147909700147909794E081-4266
chr6147910140147910190E081-3870
chr6147910489147911493E081-2567
chr6147922652147922740E0818592
chr6147922751147922821E0818691
chr6147922876147923316E0818816
chr6147906542147906626E082-7434
chr6147906709147906804E082-7256
chr6147906955147907730E082-6330
chr6147910489147911493E082-2567