rs848353

Homo sapiens
A>G
None
Check p-value
SNV (Single Nucleotide Variation)
G=0137 (4119/29908,GnomAD)
G=0173 (5063/29118,TOPMED)
G=0164 (823/5008,1000G)
G=0065 (251/3854,ALSPAC)
G=0061 (228/3708,TWINSUK)
chr7:108908603 (GRCh38.p7) (7q31.1)
ND
GWASCatalog
1   publication(s)
See rs on genome
2 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 7NC_000007.14:g.108908603A>G
GRCh37.p13 chr 7NC_000007.13:g.108548660A>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.641G=0.359
1000GenomesAmericanSub694A=0.910G=0.090
1000GenomesEast AsianSub1008A=0.857G=0.143
1000GenomesEuropeSub1006A=0.930G=0.070
1000GenomesGlobalStudy-wide5008A=0.836G=0.164
1000GenomesSouth AsianSub978A=0.930G=0.070
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.935G=0.065
The Genome Aggregation DatabaseAfricanSub8708A=0.687G=0.313
The Genome Aggregation DatabaseAmericanSub834A=0.930G=0.070
The Genome Aggregation DatabaseEast AsianSub1584A=0.847G=0.153
The Genome Aggregation DatabaseEuropeSub18480A=0.941G=0.058
The Genome Aggregation DatabaseGlobalStudy-wide29908A=0.862G=0.137
The Genome Aggregation DatabaseOtherSub302A=0.930G=0.070
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.826G=0.173
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.939G=0.061
PMID Title Author Journal
22006218Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence.Yoon DHum Genet

P-Value

SNP ID p-value Traits Study
rs8483533.00E-07Fagerstrom test for nicotine dependence22006218
rs8483539.00E-07Heaviness of Smoking Index22006218
rs8483532.00E-06Cigarettes smoked per day22006218

eQTL of rs848353 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs848353 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr7108509407108510013E070-38647
chr7108590838108591098E07042178