rs851860

Homo sapiens
A>G
None
Check p-value
SNV (Single Nucleotide Variation)
A==0145 (4345/29962,GnomAD)
A==0124 (3626/29118,TOPMED)
A==0109 (548/5008,1000G)
A==0188 (726/3854,ALSPAC)
A==0174 (645/3708,TWINSUK)
chr6:66344991 (GRCh38.p7) (6q12)
AD
GWASdb2
1   publication(s)
See rs on genome
0 Enhancer around
1 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 6NC_000006.12:g.66344991A>G
GRCh37.p13 chr 6NC_000006.11:g.67054884A>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.048G=0.952
1000GenomesAmericanSub694A=0.210G=0.790
1000GenomesEast AsianSub1008A=0.054G=0.946
1000GenomesEuropeSub1006A=0.182G=0.818
1000GenomesGlobalStudy-wide5008A=0.109G=0.891
1000GenomesSouth AsianSub978A=0.110G=0.890
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.188G=0.812
The Genome Aggregation DatabaseAfricanSub8732A=0.066G=0.934
The Genome Aggregation DatabaseAmericanSub836A=0.170G=0.830
The Genome Aggregation DatabaseEast AsianSub1620A=0.049G=0.951
The Genome Aggregation DatabaseEuropeSub18472A=0.188G=0.811
The Genome Aggregation DatabaseGlobalStudy-wide29962A=0.145G=0.855
The Genome Aggregation DatabaseOtherSub302A=0.210G=0.790
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.124G=0.875
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.174G=0.826
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs8518600.000494alcohol dependence24277619

eQTL of rs851860 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs851860 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr66703103367031235E072-23649