rs868874

Homo sapiens
T>C
ZFPM1 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0329 (9707/29486,GnomAD)
C=0352 (10252/29118,TOPMED)
C=0394 (1973/5008,1000G)
C=0314 (1211/3854,ALSPAC)
C=0304 (1129/3708,TWINSUK)
chr16:88503975 (GRCh38.p7) (16q24.2)
AD
GWASdb2
1   publication(s)
See rs on genome
145 Enhancers around
9 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 16NC_000016.10:g.88503975T>C
GRCh37.p13 chr 16NC_000016.9:g.88570383T>C

Gene: ZFPM1, zinc finger protein, FOG family member 1(plus strand)

Molecule type Change Amino acid[Codon] SO Term
ZFPM1 transcriptNM_153813.2:c.N/AIntron Variant
ZFPM1 transcript variant X1XM_011522912.2:c.N/AIntron Variant
ZFPM1 transcript variant X2XM_011522914.2:c.N/AIntron Variant
ZFPM1 transcript variant X4XM_017022982.1:c.N/AIntron Variant
ZFPM1 transcript variant X3XM_011522917.2:c.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.602C=0.398
1000GenomesAmericanSub694T=0.630C=0.370
1000GenomesEast AsianSub1008T=0.512C=0.488
1000GenomesEuropeSub1006T=0.675C=0.325
1000GenomesGlobalStudy-wide5008T=0.606C=0.394
1000GenomesSouth AsianSub978T=0.620C=0.380
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.686C=0.314
The Genome Aggregation DatabaseAfricanSub8520T=0.637C=0.363
The Genome Aggregation DatabaseAmericanSub834T=0.640C=0.360
The Genome Aggregation DatabaseEast AsianSub1600T=0.519C=0.481
The Genome Aggregation DatabaseEuropeSub18230T=0.703C=0.297
The Genome Aggregation DatabaseGlobalStudy-wide29486T=0.670C=0.329
The Genome Aggregation DatabaseOtherSub302T=0.590C=0.410
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.647C=0.352
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.696C=0.304
PMID Title Author Journal
23089632A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53.Wang JCMol Psychiatry

P-Value

SNP ID p-value Traits Study
rs8688741.28E-05alcohol dependence23089632

eQTL of rs868874 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs868874 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr168852325288523700E067-46683
chr168858872388588773E06718340
chr168858880388588882E06718420
chr168858891888589274E06718535
chr168858960588590122E06719222
chr168859018488590457E06719801
chr168860204288602092E06731659
chr168860213588602229E06731752
chr168858122388581618E06810840
chr168858831288588695E06817929
chr168858872388588773E06818340
chr168858880388588882E06818420
chr168858891888589274E06818535
chr168858942288589470E06819039
chr168858960588590122E06819222
chr168859018488590457E06819801
chr168860204288602092E06831659
chr168860213588602229E06831752
chr168858175888581822E06911375
chr168858831288588695E06917929
chr168858872388588773E06918340
chr168858880388588882E06918420
chr168858891888589274E06918535
chr168858942288589470E06919039
chr168858960588590122E06919222
chr168859018488590457E06919801
chr168852325288523700E070-46683
chr168854721788547482E070-22901
chr168854755888547609E070-22774
chr168854766488547747E070-22636
chr168854797588548047E070-22336
chr168854810488548177E070-22206
chr168854836688548459E070-21924
chr168854858688548790E070-21593
chr168854882288548924E070-21459
chr168854908788549575E070-20808
chr168855077988550866E070-19517
chr168855098088551174E070-19209
chr168855117988551686E070-18697
chr168858831288588695E07017929
chr168858872388588773E07018340
chr168858891888589274E07018535
chr168858942288589470E07019039
chr168858960588590122E07019222
chr168859018488590457E07019801
chr168859060788590689E07020224
chr168859075088590812E07020367
chr168859091688591164E07020533
chr168859569788596104E07025314
chr168859615088596209E07025767
chr168859624988596409E07025866
chr168859647788596620E07026094
chr168859668288596759E07026299
chr168859677588596999E07026392
chr168859708588598311E07026702
chr168860204288602092E07031659
chr168860213588602229E07031752
chr168860225488602308E07031871
chr168860732188607937E07036938
chr168860833788608521E07037954
chr168860855988608944E07038176
chr168858122388581618E07110840
chr168858175888581822E07111375
chr168858194388581993E07111560
chr168858831288588695E07117929
chr168858872388588773E07118340
chr168858880388588882E07118420
chr168858891888589274E07118535
chr168858942288589470E07119039
chr168858960588590122E07119222
chr168859018488590457E07119801
chr168859060788590689E07120224
chr168859075088590812E07120367
chr168859091688591164E07120533
chr168859831288598888E07127929
chr168860204288602092E07131659
chr168860213588602229E07131752
chr168860225488602308E07131871
chr168860238988602615E07132006
chr168858753588587726E07217152
chr168858802488588074E07217641
chr168858831288588695E07217929
chr168858872388588773E07218340
chr168858880388588882E07218420
chr168858891888589274E07218535
chr168858942288589470E07219039
chr168858960588590122E07219222
chr168859018488590457E07219801
chr168859060788590689E07220224
chr168859075088590812E07220367
chr168859091688591164E07220533
chr168859123888591307E07220855
chr168859135288591540E07220969
chr168859324488594699E07222861
chr168860204288602092E07231659
chr168860213588602229E07231752
chr168852325288523700E073-46683
chr168852370788523904E073-46479
chr168858753588587726E07317152
chr168858802488588074E07317641
chr168858831288588695E07317929
chr168858872388588773E07318340
chr168858880388588882E07318420
chr168858891888589274E07318535
chr168858942288589470E07319039
chr168858960588590122E07319222
chr168859018488590457E07319801
chr168859060788590689E07320224
chr168859075088590812E07320367
chr168859091688591164E07320533
chr168859324488594699E07322861
chr168859831288598888E07327929
chr168859890788599651E07328524
chr168860204288602092E07331659
chr168860213588602229E07331752
chr168860225488602308E07331871
chr168860238988602615E07332006
chr168858831288588695E07417929
chr168858872388588773E07418340
chr168858880388588882E07418420
chr168858891888589274E07418535
chr168858942288589470E07419039
chr168858960588590122E07419222
chr168859324488594699E07422861
chr168857668788576756E0816304
chr168857681788577076E0816434
chr168857711288577192E0816729
chr168858960588590122E08119222
chr168859018488590457E08119801
chr168859668288596759E08126299
chr168859677588596999E08126392
chr168859708588598311E08126702
chr168859831288598888E08127929
chr168859890788599651E08128524
chr168860204288602092E08131659
chr168860213588602229E08131752
chr168854147988541564E082-28819
chr168855077988550866E082-19517
chr168858175888581822E08211375
chr168858194388581993E08211560
chr168858942288589470E08219039
chr168858960588590122E08219222
chr168859324488594699E08222861
chr168859708588598311E08226702
chr168860225488602308E08231871










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr168859972088601005E06729337
chr168859972088601005E06829337
chr168859972088601005E06929337
chr168859972088601005E07029337
chr168859972088601005E07129337
chr168859972088601005E07229337
chr168859972088601005E07329337
chr168859972088601005E07429337
chr168859972088601005E08229337