rs874651

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0150 (4517/29954,GnomAD)
T=0161 (4695/29118,TOPMED)
T=0147 (736/5008,1000G)
T=0152 (585/3854,ALSPAC)
T=0156 (580/3708,TWINSUK)
chr11:11757827 (GRCh38.p7) (11p15.3)
AD
GWASdb2
1   publication(s)
See rs on genome
78 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 11NC_000011.10:g.11757827C>T
GRCh37.p13 chr 11NC_000011.9:g.11779374C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.853T=0.147
1000GenomesAmericanSub694C=0.890T=0.110
1000GenomesEast AsianSub1008C=0.829T=0.171
1000GenomesEuropeSub1006C=0.811T=0.189
1000GenomesGlobalStudy-wide5008C=0.853T=0.147
1000GenomesSouth AsianSub978C=0.890T=0.110
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.848T=0.152
The Genome Aggregation DatabaseAfricanSub8720C=0.852T=0.148
The Genome Aggregation DatabaseAmericanSub838C=0.880T=0.120
The Genome Aggregation DatabaseEast AsianSub1616C=0.850T=0.150
The Genome Aggregation DatabaseEuropeSub18478C=0.847T=0.152
The Genome Aggregation DatabaseGlobalStudy-wide29954C=0.849T=0.150
The Genome Aggregation DatabaseOtherSub302C=0.800T=0.200
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.838T=0.161
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.844T=0.156
PMID Title Author Journal
21529783A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications.Heath ACBiol Psychiatry

P-Value

SNP ID p-value Traits Study
rs8746517.9E-05alcoholism (heaviness of drinking)21529783

eQTL of rs874651 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs874651 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr111180903211809783E06729658
chr111182088811820938E06741514
chr111182106311821180E06741689
chr111182128311821501E06741909
chr111182779911827849E06748425
chr111182794711828658E06748573
chr111182875511828799E06749381
chr111182895011829018E06749576
chr111182920011829298E06749826
chr111175278611753793E068-25581
chr111180822311808281E06828849
chr111180828511808609E06828911
chr111180869411808737E06829320
chr111180875011808845E06829376
chr111180888711809028E06829513
chr111180903211809783E06829658
chr111182004411820837E06840670
chr111182088811820938E06841514
chr111182106311821180E06841689
chr111182128311821501E06841909
chr111182163211821687E06842258
chr111182794711828658E06848573
chr111182875511828799E06849381
chr111182895011829018E06849576
chr111182920011829298E06849826
chr111180875011808845E06929376
chr111180888711809028E06929513
chr111180903211809783E06929658
chr111182004411820837E06940670
chr111182088811820938E06941514
chr111182106311821180E06941689
chr111182779911827849E06948425
chr111182794711828658E06948573
chr111175278611753793E070-25581
chr111180365811803708E07024284
chr111180370911803773E07024335
chr111180412111804608E07024747
chr111180869411808737E07129320
chr111180875011808845E07129376
chr111180888711809028E07129513
chr111180903211809783E07129658
chr111182004411820837E07140670
chr111182088811820938E07141514
chr111182106311821180E07141689
chr111182128311821501E07141909
chr111182163211821687E07142258
chr111182194111821991E07142567
chr111182779911827849E07148425
chr111182794711828658E07148573
chr111182895011829018E07149576
chr111182088811820938E07241514
chr111182106311821180E07241689
chr111182128311821501E07241909
chr111182779911827849E07248425
chr111182794711828658E07248573
chr111182875511828799E07249381
chr111182895011829018E07249576
chr111182920011829298E07249826
chr111180903211809783E07329658
chr111180875011808845E07429376
chr111180888711809028E07429513
chr111182004411820837E07440670
chr111182088811820938E07441514
chr111182106311821180E07441689
chr111182128311821501E07441909
chr111182779911827849E07448425
chr111182794711828658E07448573
chr111182895011829018E07449576
chr111182920011829298E07449826
chr111173227411732412E081-46962
chr111175241311752493E081-26881
chr111180875011808845E08129376
chr111180888711809028E08129513
chr111180903211809783E08129658
chr111173227411732412E082-46962
chr111180875011808845E08229376
chr111180888711809028E08229513
chr111180903211809783E08229658