rs875778

Homo sapiens
T>C
GRAMD4 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T==0245 (7318/29870,GnomAD)
T==0267 (7799/29114,TOPMED)
T==0224 (1122/5008,1000G)
T==0307 (1183/3854,ALSPAC)
T==0307 (1137/3708,TWINSUK)
chr22:46588409 (GRCh38.p7) (22q13.31)
AD
GWASdb2
1   publication(s)
See rs on genome
280 Enhancers around
9 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 22NC_000022.11:g.46588409T>C
GRCh37.p13 chr 22NC_000022.10:g.46984306T>C

Gene: GRAMD4, GRAM domain containing 4(plus strand)

Molecule type Change Amino acid[Codon] SO Term
GRAMD4 transcriptNM_015124.4:c.N/AGenic Upstream Transcript Variant
GRAMD4 transcript variant X3XM_005261396.3:c.N/AIntron Variant
GRAMD4 transcript variant X4XM_006724169.1:c.N/AIntron Variant
GRAMD4 transcript variant X8XM_011530013.2:c.N/AIntron Variant
GRAMD4 transcript variant X6XM_006724170.3:c.N/AGenic Upstream Transcript Variant
GRAMD4 transcript variant X1XM_011530011.1:c.N/AGenic Upstream Transcript Variant
GRAMD4 transcript variant X2XM_011530012.1:c.N/AGenic Upstream Transcript Variant
GRAMD4 transcript variant X7XM_011530014.2:c.N/AGenic Upstream Transcript Variant
GRAMD4 transcript variant X5XM_017028670.1:c.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.163C=0.837
1000GenomesAmericanSub694T=0.350C=0.650
1000GenomesEast AsianSub1008T=0.078C=0.922
1000GenomesEuropeSub1006T=0.305C=0.695
1000GenomesGlobalStudy-wide5008T=0.224C=0.776
1000GenomesSouth AsianSub978T=0.280C=0.720
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.307C=0.693
The Genome Aggregation DatabaseAfricanSub8708T=0.182C=0.818
The Genome Aggregation DatabaseAmericanSub834T=0.310C=0.690
The Genome Aggregation DatabaseEast AsianSub1622T=0.070C=0.930
The Genome Aggregation DatabaseEuropeSub18406T=0.286C=0.713
The Genome Aggregation DatabaseGlobalStudy-wide29870T=0.245C=0.755
The Genome Aggregation DatabaseOtherSub300T=0.310C=0.690
Trans-Omics for Precision MedicineGlobalStudy-wide29114T=0.267C=0.732
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.307C=0.693
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs8757780.00097alcohol dependence24277619

eQTL of rs875778 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs875778 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr224697578046975895E067-8411
chr224697599646976106E067-8200
chr224697615146976290E067-8016
chr224698019746981036E067-3270
chr224698170846981781E067-2525
chr224698726246987458E0672956
chr224698781446988053E0673508
chr224698807146989629E0673765
chr224699180846992385E0677502
chr224700623947006319E06721933
chr224700632847006730E06722022
chr224700675547006838E06722449
chr224701368247014088E06729376
chr224701417647014247E06729870
chr224701467647016411E06730370
chr224701657847016758E06732272
chr224701678747016850E06732481
chr224694260446944181E068-40125
chr224697578046975895E068-8411
chr224698292946985206E0680
chr224698582646985968E0681520
chr224698617046986630E0681864
chr224698781446988053E0683508
chr224699090646991083E0686600
chr224699152646991727E0687220
chr224699180846992385E0687502
chr224700487347005795E06820567
chr224700583347005936E06821527
chr224700595347006236E06821647
chr224700623947006319E06821933
chr224700819747008293E06823891
chr224700831647009902E06824010
chr224701300347013642E06828697
chr224701368247014088E06829376
chr224701417647014247E06829870
chr224701467647016411E06830370
chr224701657847016758E06832272
chr224701678747016850E06832481
chr224701690947016949E06832603
chr224701697347017082E06832667
chr224701710347017206E06832797
chr224701723847017350E06832932
chr224701763747017787E06833331
chr224702299447023914E06838688
chr224694260446944181E069-40125
chr224697474446975766E069-8540
chr224697578046975895E069-8411
chr224697599646976106E069-8200
chr224698273246982890E069-1416
chr224698292946985206E0690
chr224698523146985281E069925
chr224698530746985511E0691001
chr224698558646985783E0691280
chr224698582646985968E0691520
chr224698781446988053E0693508
chr224699180846992385E0697502
chr224700595347006236E06921647
chr224700623947006319E06921933
chr224700632847006730E06922022
chr224700831647009902E06924010
chr224701300347013642E06928697
chr224701368247014088E06929376
chr224701417647014247E06929870
chr224701467647016411E06930370
chr224701657847016758E06932272
chr224701678747016850E06932481
chr224701690947016949E06932603
chr224701697347017082E06932667
chr224701710347017206E06932797
chr224701723847017350E06932932
chr224701763747017787E06933331
chr224701795047018431E06933644
chr224702658947026639E06942283
chr224702676347026857E06942457
chr224702693847026988E06942632
chr224703220347032318E06947897
chr224694260446944181E070-40125
chr224694508646945192E070-39114
chr224694522946945434E070-38872
chr224697578046975895E070-8411
chr224697599646976106E070-8200
chr224697615146976290E070-8016
chr224697631846976610E070-7696
chr224697984946980025E070-4281
chr224698019746981036E070-3270
chr224698140846981551E070-2755
chr224698170846981781E070-2525
chr224698248346982677E070-1629
chr224698273246982890E070-1416
chr224698292946985206E0700
chr224698807146989629E0703765
chr224699070146990751E0706395
chr224699152646991727E0707220
chr224699180846992385E0707502
chr224699244446992557E0708138
chr224700831647009902E07024010
chr224701300347013642E07028697
chr224701368247014088E07029376
chr224701417647014247E07029870
chr224701467647016411E07030370
chr224701657847016758E07032272
chr224701678747016850E07032481
chr224701690947016949E07032603
chr224701697347017082E07032667
chr224701710347017206E07032797
chr224701723847017350E07032932
chr224701763747017787E07033331
chr224701795047018431E07033644
chr224701843747018551E07034131
chr224694260446944181E071-40125
chr224697599646976106E071-8200
chr224697615146976290E071-8016
chr224697631846976610E071-7696
chr224698292946985206E0710
chr224698523146985281E071925
chr224698530746985511E0711001
chr224698558646985783E0711280
chr224698582646985968E0711520
chr224698617046986630E0711864
chr224698713946987231E0712833
chr224698726246987458E0712956
chr224698781446988053E0713508
chr224699152646991727E0717220
chr224699180846992385E0717502
chr224699586546995967E07111559
chr224699606746996146E07111761
chr224699630346996598E07111997
chr224700487347005795E07120567
chr224700583347005936E07121527
chr224700595347006236E07121647
chr224700623947006319E07121933
chr224700632847006730E07122022
chr224700675547006838E07122449
chr224700831647009902E07124010
chr224701300347013642E07128697
chr224701368247014088E07129376
chr224701417647014247E07129870
chr224701467647016411E07130370
chr224701657847016758E07132272
chr224701678747016850E07132481
chr224701690947016949E07132603
chr224701697347017082E07132667
chr224701710347017206E07132797
chr224701723847017350E07132932
chr224701763747017787E07133331
chr224701795047018431E07133644
chr224697474446975766E072-8540
chr224697984946980025E072-4281
chr224698019746981036E072-3270
chr224698248346982677E072-1629
chr224698273246982890E072-1416
chr224698292946985206E0720
chr224698523146985281E072925
chr224698530746985511E0721001
chr224698558646985783E0721280
chr224698582646985968E0721520
chr224698617046986630E0721864
chr224698781446988053E0723508
chr224698807146989629E0723765
chr224699180846992385E0727502
chr224699567146995790E07211365
chr224699586546995967E07211559
chr224699606746996146E07211761
chr224699630346996598E07211997
chr224700819747008293E07223891
chr224700831647009902E07224010
chr224701300347013642E07228697
chr224701368247014088E07229376
chr224701417647014247E07229870
chr224701467647016411E07230370
chr224701657847016758E07232272
chr224701678747016850E07232481
chr224701690947016949E07232603
chr224701697347017082E07232667
chr224702842447028474E07244118
chr224702853047028596E07244224
chr224702860847028676E07244302
chr224702870447028872E07244398
chr224695918646960517E073-23789
chr224697578046975895E073-8411
chr224697599646976106E073-8200
chr224697615146976290E073-8016
chr224697631846976610E073-7696
chr224698530746985511E0731001
chr224698558646985783E0731280
chr224698582646985968E0731520
chr224698617046986630E0731864
chr224698713946987231E0732833
chr224698807146989629E0733765
chr224699180846992385E0737502
chr224700487347005795E07320567
chr224700583347005936E07321527
chr224700595347006236E07321647
chr224700623947006319E07321933
chr224700632847006730E07322022
chr224700675547006838E07322449
chr224700831647009902E07324010
chr224701300347013642E07328697
chr224701368247014088E07329376
chr224701417647014247E07329870
chr224701467647016411E07330370
chr224701657847016758E07332272
chr224701678747016850E07332481
chr224701690947016949E07332603
chr224701697347017082E07332667
chr224701710347017206E07332797
chr224701723847017350E07332932
chr224701763747017787E07333331
chr224697474446975766E074-8540
chr224697578046975895E074-8411
chr224697599646976106E074-8200
chr224697615146976290E074-8016
chr224697631846976610E074-7696
chr224697691246978850E074-5456
chr224698248346982677E074-1629
chr224698273246982890E074-1416
chr224698292946985206E0740
chr224698523146985281E074925
chr224698530746985511E0741001
chr224698558646985783E0741280
chr224698781446988053E0743508
chr224699180846992385E0747502
chr224700595347006236E07421647
chr224700623947006319E07421933
chr224700632847006730E07422022
chr224700831647009902E07424010
chr224701300347013642E07428697
chr224701368247014088E07429376
chr224701417647014247E07429870
chr224701467647016411E07430370
chr224701657847016758E07432272
chr224701678747016850E07432481
chr224701690947016949E07432603
chr224701697347017082E07432667
chr224701710347017206E07432797
chr224701723847017350E07432932
chr224701763747017787E07433331
chr224701901347019093E07434707
chr224701909747019227E07434791
chr224701959347019666E07435287
chr224703220347032318E07447897
chr224697474446975766E081-8540
chr224697578046975895E081-8411
chr224697599646976106E081-8200
chr224697615146976290E081-8016
chr224697631846976610E081-7696
chr224697670146976766E081-7540
chr224697984946980025E081-4281
chr224698019746981036E081-3270
chr224698140846981551E081-2755
chr224698170846981781E081-2525
chr224698182146981926E081-2380
chr224698205046982269E081-2037
chr224698233546982385E081-1921
chr224698248346982677E081-1629
chr224698273246982890E081-1416
chr224698292946985206E0810
chr224698558646985783E0811280
chr224701300347013642E08128697
chr224701368247014088E08129376
chr224701417647014247E08129870
chr224701467647016411E08130370
chr224701657847016758E08132272
chr224701678747016850E08132481
chr224701690947016949E08132603
chr224701697347017082E08132667
chr224701710347017206E08132797
chr224701723847017350E08132932
chr224701763747017787E08133331
chr224701843747018551E08134131
chr224697599646976106E082-8200
chr224697615146976290E082-8016
chr224697631846976610E082-7696
chr224698273246982890E082-1416
chr224699152646991727E0827220
chr224699180846992385E0827502
chr224700595347006236E08221647
chr224700623947006319E08221933
chr224700632847006730E08222022
chr224701467647016411E08230370










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr224697331846973457E067-10849
chr224697331846973457E068-10849
chr224697331846973457E069-10849
chr224697331846973457E070-10849
chr224697331846973457E071-10849
chr224697331846973457E072-10849
chr224697331846973457E073-10849
chr224697331846973457E074-10849
chr224697331846973457E082-10849