rs878913

Organism: Homo sapiens

Alleles: C>G / C>T

Gene : Feature

FHOD3 : Intron Variant

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

G=0126 (3787/29882,GnomAD)
G=0150 (4380/29118,TOPMED)
G=0175 (876/5008,1000G)
G=0078 (302/3854,ALSPAC)
G=0067 (247/3708,TWINSUK)

Position: chr18:36454768 (GRCh38.p7) (18q12.2)

Phenotype: CD

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 0 Enhancer around

Promoter: 0 Promoter around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 18	NC_000018.10:g.36454768C>G
GRCh38.p7 chr 18	NC_000018.10:g.36454768C>T
GRCh37.p13 chr 18	NC_000018.9:g.34034731C>G
GRCh37.p13 chr 18	NC_000018.9:g.34034731C>T
FHOD3 RefSeqGene	NG_042837.1:g.162073C>G
FHOD3 RefSeqGene	NG_042837.1:g.162073C>T

Gene: FHOD3, formin homology 2 domain containing 3(plus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
FHOD3 transcript variant 2	NM_001281739.2:c.	N/A	Intron Variant
FHOD3 transcript variant 3	NM_001281740.2:c.	N/A	Intron Variant
FHOD3 transcript variant 1	NM_025135.4:c.	N/A	Intron Variant
FHOD3 transcript variant X6	XM_005258349.1:c.	N/A	Intron Variant
FHOD3 transcript variant X12	XM_005258354.1:c.	N/A	Intron Variant
FHOD3 transcript variant X13	XM_005258355.1:c.	N/A	Intron Variant
FHOD3 transcript variant X1	XM_011526189.1:c.	N/A	Intron Variant
FHOD3 transcript variant X2	XM_011526190.1:c.	N/A	Intron Variant
FHOD3 transcript variant X3	XM_011526192.1:c.	N/A	Intron Variant
FHOD3 transcript variant X4	XM_011526193.2:c.	N/A	Intron Variant
FHOD3 transcript variant X9	XM_011526195.1:c.	N/A	Intron Variant
FHOD3 transcript variant X10	XM_011526196.1:c.	N/A	Intron Variant
FHOD3 transcript variant X16	XM_011526197.1:c.	N/A	Intron Variant
FHOD3 transcript variant X5	XM_017026006.1:c.	N/A	Intron Variant
FHOD3 transcript variant X8	XM_017026008.1:c.	N/A	Intron Variant
FHOD3 transcript variant X11	XM_017026009.1:c.	N/A	Intron Variant
FHOD3 transcript variant X15	XM_017026010.1:c.	N/A	Intron Variant
FHOD3 transcript variant X7	XM_017026007.1:c.	N/A	Genic Upstream Transcript Variant

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	C=0.809	G=0.191
1000Genomes	American	Sub	694	C=0.740	G=0.260
1000Genomes	East Asian	Sub	1008	C=0.674	G=0.326
1000Genomes	Europe	Sub	1006	C=0.929	G=0.071
1000Genomes	Global	Study-wide	5008	C=0.825	G=0.175
1000Genomes	South Asian	Sub	978	C=0.960	G=0.040
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	C=0.922	G=0.078
The Genome Aggregation Database	African	Sub	8674	C=0.805	T=0.000
The Genome Aggregation Database	American	Sub	834	C=0.750	T=0.00,
The Genome Aggregation Database	East Asian	Sub	1616	C=0.708	T=0.000
The Genome Aggregation Database	Europe	Sub	18456	C=0.924	T=0.000
The Genome Aggregation Database	Global	Study-wide	29882	C=0.873	T=0.000
The Genome Aggregation Database	Other	Sub	302	C=0.940	T=0.00,
Trans-Omics for Precision Medicine	Global	Study-wide	29118	C=0.849	G=0.150
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	C=0.933	G=0.067

PMID	Title	Author	Journal
23958962	Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.	Gelernter J	Mol Psychiatry

P-Value

SNP ID	p-value	Traits	Study
rs878913	0.0000312	Cocaine induced paranoia, AA	23958962
rs878913	0.000151	Cocaine induced paranoia	23958962

eQTL of rs878913 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs878913 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.