rs894290

Organism: Homo sapiens

Alleles: A>G

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

G=0299 (8959/29932,GnomAD)
G=0347 (10114/29118,TOPMED)
G=0310 (1551/5008,1000G)
G=0222 (854/3854,ALSPAC)
G=0220 (817/3708,TWINSUK)

Position: chr15:88281450 (GRCh38.p7) (15q25.3)

Phenotype: AD

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 203 Enhancers around

Promoter: 116 Promoters around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 15	NC_000015.10:g.88281450A>G
GRCh37.p13 chr 15	NC_000015.9:g.88824681A>G

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	A=0.452	G=0.548
1000Genomes	American	Sub	694	A=0.700	G=0.300
1000Genomes	East Asian	Sub	1008	A=0.858	G=0.142
1000Genomes	Europe	Sub	1006	A=0.799	G=0.201
1000Genomes	Global	Study-wide	5008	A=0.690	G=0.310
1000Genomes	South Asian	Sub	978	A=0.720	G=0.280
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	A=0.778	G=0.222
The Genome Aggregation Database	African	Sub	8704	A=0.479	G=0.521
The Genome Aggregation Database	American	Sub	838	A=0.740	G=0.260
The Genome Aggregation Database	East Asian	Sub	1620	A=0.863	G=0.137
The Genome Aggregation Database	Europe	Sub	18468	A=0.787	G=0.213
The Genome Aggregation Database	Global	Study-wide	29932	A=0.700	G=0.299
The Genome Aggregation Database	Other	Sub	302	A=0.830	G=0.170
Trans-Omics for Precision Medicine	Global	Study-wide	29118	A=0.652	G=0.347
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	A=0.780	G=0.220

PMID	Title	Author	Journal
20201924	Genome-wide association study of alcohol dependence implicates a region on chromosome 11.	Edenberg HJ	Alcohol Clin Exp Res

P-Value

SNP ID	p-value	Traits	Study
rs894290	0.0000303	alcoholism	pha002891
rs894290	0.0000303	alcohol dependence	20201924

eQTL of rs894290 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs894290 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr15	88777351	88777426	E067	-47255
chr15	88777459	88777509	E067	-47172
chr15	88784339	88784510	E067	-40171
chr15	88784656	88784715	E067	-39966
chr15	88784752	88784860	E067	-39821
chr15	88784915	88784955	E067	-39726
chr15	88785132	88785182	E067	-39499
chr15	88789372	88789721	E067	-34960
chr15	88790808	88790965	E067	-33716
chr15	88791320	88791462	E067	-33219
chr15	88791979	88792038	E067	-32643
chr15	88792194	88792290	E067	-32391
chr15	88792562	88792703	E067	-31978
chr15	88792850	88792900	E067	-31781
chr15	88793183	88793237	E067	-31444
chr15	88794198	88794412	E067	-30269
chr15	88794551	88794601	E067	-30080
chr15	88794895	88794957	E067	-29724
chr15	88795778	88795818	E067	-28863
chr15	88775030	88775080	E068	-49601
chr15	88775264	88775331	E068	-49350
chr15	88775456	88775506	E068	-49175
chr15	88775628	88775727	E068	-48954
chr15	88775959	88776139	E068	-48542
chr15	88776631	88776709	E068	-47972
chr15	88777351	88777426	E068	-47255
chr15	88777459	88777509	E068	-47172
chr15	88778274	88778324	E068	-46357
chr15	88778669	88778735	E068	-45946
chr15	88785944	88786253	E068	-38428
chr15	88786329	88786662	E068	-38019
chr15	88787036	88787103	E068	-37578
chr15	88789168	88789228	E068	-35453
chr15	88789281	88789331	E068	-35350
chr15	88789372	88789721	E068	-34960
chr15	88791320	88791462	E068	-33219
chr15	88791979	88792038	E068	-32643
chr15	88792194	88792290	E068	-32391
chr15	88792562	88792703	E068	-31978
chr15	88792850	88792900	E068	-31781
chr15	88793183	88793237	E068	-31444
chr15	88793933	88793996	E068	-30685
chr15	88794198	88794412	E068	-30269
chr15	88794551	88794601	E068	-30080
chr15	88794895	88794957	E068	-29724
chr15	88844880	88845135	E068	20199
chr15	88845522	88845947	E068	20841
chr15	88776631	88776709	E069	-47972
chr15	88776967	88777204	E069	-47477
chr15	88778669	88778735	E069	-45946
chr15	88789372	88789721	E069	-34960
chr15	88790808	88790965	E069	-33716
chr15	88791320	88791462	E069	-33219
chr15	88792194	88792290	E069	-32391
chr15	88794198	88794412	E069	-30269
chr15	88794551	88794601	E069	-30080
chr15	88794895	88794957	E069	-29724
chr15	88795778	88795818	E069	-28863
chr15	88775959	88776139	E070	-48542
chr15	88776237	88776525	E070	-48156
chr15	88789818	88790694	E070	-33987
chr15	88775959	88776139	E071	-48542
chr15	88776237	88776525	E071	-48156
chr15	88776631	88776709	E071	-47972
chr15	88784656	88784715	E071	-39966
chr15	88788731	88788788	E071	-35893
chr15	88789168	88789228	E071	-35453
chr15	88789281	88789331	E071	-35350
chr15	88789372	88789721	E071	-34960
chr15	88790808	88790965	E071	-33716
chr15	88791320	88791462	E071	-33219
chr15	88791979	88792038	E071	-32643
chr15	88792194	88792290	E071	-32391
chr15	88792562	88792703	E071	-31978
chr15	88792850	88792900	E071	-31781
chr15	88793183	88793237	E071	-31444
chr15	88793933	88793996	E071	-30685
chr15	88794198	88794412	E071	-30269
chr15	88794551	88794601	E071	-30080
chr15	88794895	88794957	E071	-29724
chr15	88795778	88795818	E071	-28863
chr15	88778274	88778324	E072	-46357
chr15	88784339	88784510	E072	-40171
chr15	88784656	88784715	E072	-39966
chr15	88784752	88784860	E072	-39821
chr15	88785944	88786253	E072	-38428
chr15	88786329	88786662	E072	-38019
chr15	88786716	88786766	E072	-37915
chr15	88790808	88790965	E072	-33716
chr15	88791320	88791462	E072	-33219
chr15	88793183	88793237	E072	-31444
chr15	88793933	88793996	E072	-30685
chr15	88794198	88794412	E072	-30269
chr15	88794551	88794601	E072	-30080
chr15	88794895	88794957	E072	-29724
chr15	88776631	88776709	E073	-47972
chr15	88783770	88783829	E073	-40852
chr15	88784339	88784510	E073	-40171
chr15	88784656	88784715	E073	-39966
chr15	88784752	88784860	E073	-39821
chr15	88784915	88784955	E073	-39726
chr15	88785132	88785182	E073	-39499
chr15	88785477	88785527	E073	-39154
chr15	88785528	88785578	E073	-39103
chr15	88789168	88789228	E073	-35453
chr15	88789281	88789331	E073	-35350
chr15	88789372	88789721	E073	-34960
chr15	88791320	88791462	E073	-33219
chr15	88791979	88792038	E073	-32643
chr15	88792194	88792290	E073	-32391
chr15	88792562	88792703	E073	-31978
chr15	88792850	88792900	E073	-31781
chr15	88793183	88793237	E073	-31444
chr15	88793933	88793996	E073	-30685
chr15	88794198	88794412	E073	-30269
chr15	88775959	88776139	E074	-48542
chr15	88784656	88784715	E074	-39966
chr15	88789168	88789228	E074	-35453
chr15	88789281	88789331	E074	-35350
chr15	88789372	88789721	E074	-34960
chr15	88789818	88790694	E074	-33987
chr15	88790808	88790965	E074	-33716
chr15	88791979	88792038	E074	-32643
chr15	88792194	88792290	E074	-32391
chr15	88792562	88792703	E074	-31978
chr15	88775959	88776139	E081	-48542
chr15	88776237	88776525	E081	-48156
chr15	88776631	88776709	E081	-47972
chr15	88776967	88777204	E081	-47477
chr15	88777351	88777426	E081	-47255
chr15	88777459	88777509	E081	-47172
chr15	88777680	88777730	E081	-46951
chr15	88784339	88784510	E081	-40171
chr15	88784656	88784715	E081	-39966
chr15	88784752	88784860	E081	-39821
chr15	88784915	88784955	E081	-39726
chr15	88785132	88785182	E081	-39499
chr15	88785477	88785527	E081	-39154
chr15	88785528	88785578	E081	-39103
chr15	88785879	88785933	E081	-38748
chr15	88785944	88786253	E081	-38428
chr15	88786329	88786662	E081	-38019
chr15	88786716	88786766	E081	-37915
chr15	88786927	88786977	E081	-37704
chr15	88789372	88789721	E081	-34960
chr15	88789818	88790694	E081	-33987
chr15	88790808	88790965	E081	-33716
chr15	88791320	88791462	E081	-33219
chr15	88792194	88792290	E081	-32391
chr15	88794551	88794601	E081	-30080
chr15	88794895	88794957	E081	-29724
chr15	88795778	88795818	E081	-28863
chr15	88802154	88802208	E081	-22473
chr15	88812740	88812866	E081	-11815
chr15	88813007	88813161	E081	-11520
chr15	88813175	88813247	E081	-11434
chr15	88817717	88818209	E081	-6472
chr15	88818233	88818293	E081	-6388
chr15	88819153	88819236	E081	-5445
chr15	88819375	88819425	E081	-5256
chr15	88819457	88819507	E081	-5174
chr15	88819526	88819580	E081	-5101
chr15	88819916	88820707	E081	-3974
chr15	88820842	88820974	E081	-3707
chr15	88821193	88821243	E081	-3438
chr15	88821414	88821464	E081	-3217
chr15	88821593	88821647	E081	-3034
chr15	88821685	88821735	E081	-2946
chr15	88822627	88822677	E081	-2004
chr15	88827609	88827720	E081	2928
chr15	88827756	88828545	E081	3075
chr15	88842463	88842650	E081	17782
chr15	88842810	88843041	E081	18129
chr15	88843073	88843686	E081	18392
chr15	88843912	88844020	E081	19231
chr15	88844233	88844420	E081	19552
chr15	88844694	88844808	E081	20013
chr15	88775030	88775080	E082	-49601
chr15	88775264	88775331	E082	-49350
chr15	88775456	88775506	E082	-49175
chr15	88775628	88775727	E082	-48954
chr15	88775959	88776139	E082	-48542
chr15	88776237	88776525	E082	-48156
chr15	88776631	88776709	E082	-47972
chr15	88785944	88786253	E082	-38428
chr15	88786329	88786662	E082	-38019
chr15	88786716	88786766	E082	-37915
chr15	88786927	88786977	E082	-37704
chr15	88787036	88787103	E082	-37578
chr15	88787141	88787537	E082	-37144
chr15	88789372	88789721	E082	-34960
chr15	88790808	88790965	E082	-33716
chr15	88791320	88791462	E082	-33219
chr15	88791979	88792038	E082	-32643
chr15	88793933	88793996	E082	-30685
chr15	88794198	88794412	E082	-30269
chr15	88794551	88794601	E082	-30080
chr15	88827756	88828545	E082	3075
chr15	88843073	88843686	E082	18392
chr15	88843912	88844020	E082	19231
chr15	88844233	88844420	E082	19552
chr15	88844694	88844808	E082	20013
chr15	88844880	88845135	E082	20199

Promoter Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr15	88796014	88796064	E067	-28617
chr15	88796329	88796379	E067	-28302
chr15	88796603	88796683	E067	-27998
chr15	88796858	88796910	E067	-27771
chr15	88797336	88797376	E067	-27305
chr15	88797400	88797471	E067	-27210
chr15	88797725	88797907	E067	-26774
chr15	88797962	88798118	E067	-26563
chr15	88798189	88798239	E067	-26442
chr15	88798273	88798341	E067	-26340
chr15	88798380	88798509	E067	-26172
chr15	88798521	88800169	E067	-24512
chr15	88800219	88800490	E067	-24191
chr15	88800583	88802034	E067	-22647
chr15	88796014	88796064	E068	-28617
chr15	88796329	88796379	E068	-28302
chr15	88796603	88796683	E068	-27998
chr15	88796858	88796910	E068	-27771
chr15	88797336	88797376	E068	-27305
chr15	88797400	88797471	E068	-27210
chr15	88797725	88797907	E068	-26774
chr15	88797962	88798118	E068	-26563
chr15	88798189	88798239	E068	-26442
chr15	88798273	88798341	E068	-26340
chr15	88798380	88798509	E068	-26172
chr15	88798521	88800169	E068	-24512
chr15	88800219	88800490	E068	-24191
chr15	88800583	88802034	E068	-22647
chr15	88796603	88796683	E069	-27998
chr15	88796858	88796910	E069	-27771
chr15	88797336	88797376	E069	-27305
chr15	88797400	88797471	E069	-27210
chr15	88797725	88797907	E069	-26774
chr15	88797962	88798118	E069	-26563
chr15	88798189	88798239	E069	-26442
chr15	88798273	88798341	E069	-26340
chr15	88798380	88798509	E069	-26172
chr15	88798521	88800169	E069	-24512
chr15	88800219	88800490	E069	-24191
chr15	88800583	88802034	E069	-22647
chr15	88797336	88797376	E070	-27305
chr15	88797400	88797471	E070	-27210
chr15	88798521	88800169	E070	-24512
chr15	88800219	88800490	E070	-24191
chr15	88796014	88796064	E071	-28617
chr15	88796329	88796379	E071	-28302
chr15	88796603	88796683	E071	-27998
chr15	88796858	88796910	E071	-27771
chr15	88797336	88797376	E071	-27305
chr15	88797400	88797471	E071	-27210
chr15	88797725	88797907	E071	-26774
chr15	88797962	88798118	E071	-26563
chr15	88798189	88798239	E071	-26442
chr15	88798273	88798341	E071	-26340
chr15	88798380	88798509	E071	-26172
chr15	88798521	88800169	E071	-24512
chr15	88800219	88800490	E071	-24191
chr15	88800583	88802034	E071	-22647
chr15	88796014	88796064	E072	-28617
chr15	88796329	88796379	E072	-28302
chr15	88796603	88796683	E072	-27998
chr15	88796858	88796910	E072	-27771
chr15	88797336	88797376	E072	-27305
chr15	88797400	88797471	E072	-27210
chr15	88797725	88797907	E072	-26774
chr15	88797962	88798118	E072	-26563
chr15	88798189	88798239	E072	-26442
chr15	88798273	88798341	E072	-26340
chr15	88798380	88798509	E072	-26172
chr15	88798521	88800169	E072	-24512
chr15	88800219	88800490	E072	-24191
chr15	88800583	88802034	E072	-22647
chr15	88796014	88796064	E073	-28617
chr15	88796329	88796379	E073	-28302
chr15	88796603	88796683	E073	-27998
chr15	88796858	88796910	E073	-27771
chr15	88797336	88797376	E073	-27305
chr15	88797400	88797471	E073	-27210
chr15	88797725	88797907	E073	-26774
chr15	88797962	88798118	E073	-26563
chr15	88798189	88798239	E073	-26442
chr15	88798273	88798341	E073	-26340
chr15	88798380	88798509	E073	-26172
chr15	88798521	88800169	E073	-24512
chr15	88800219	88800490	E073	-24191
chr15	88800583	88802034	E073	-22647
chr15	88797336	88797376	E074	-27305
chr15	88797400	88797471	E074	-27210
chr15	88797725	88797907	E074	-26774
chr15	88797962	88798118	E074	-26563
chr15	88798189	88798239	E074	-26442
chr15	88798273	88798341	E074	-26340
chr15	88798380	88798509	E074	-26172
chr15	88798521	88800169	E074	-24512
chr15	88800219	88800490	E074	-24191
chr15	88800583	88802034	E074	-22647
chr15	88797336	88797376	E081	-27305
chr15	88797400	88797471	E081	-27210
chr15	88797725	88797907	E081	-26774
chr15	88797962	88798118	E081	-26563
chr15	88798189	88798239	E081	-26442
chr15	88798273	88798341	E081	-26340
chr15	88798380	88798509	E081	-26172
chr15	88798521	88800169	E081	-24512
chr15	88800219	88800490	E081	-24191
chr15	88800583	88802034	E081	-22647
chr15	88796329	88796379	E082	-28302
chr15	88796603	88796683	E082	-27998
chr15	88796858	88796910	E082	-27771
chr15	88797336	88797376	E082	-27305
chr15	88797400	88797471	E082	-27210
chr15	88797725	88797907	E082	-26774
chr15	88797962	88798118	E082	-26563
chr15	88798521	88800169	E082	-24512
chr15	88800219	88800490	E082	-24191
chr15	88800583	88802034	E082	-22647